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Genomic profiling of breast cancer by microarray-based technology and bioinformatics

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to

Aerosolsammansättning i ett renluftsområde

Aerosolsammansättningen i ett renluftsområde i Mellansverige (Velen) har studerats under en årscykel. Aerosolpartiklarna har uppdelats efter aerodynamisk storlek i 7 fraktioner. Varje fraktion från 113 provtagningstillfällen har analyserats m a p svavel och tungmetaller m h a partikelinducerad röntgenstrålning s k PIXE-analys. Resultaten påvisar variationer i ämneskoncentrationer mellan enskilda m

Perceived Self-image, Intellectual Ability, Frontal Lobe Function, and Perceived Ward Atmosphere among Patients with Psychosis

Popular Abstract in Swedish Avhandlingen påbörjades 1997 vid den Psykiatriska Rehabiliteringsenheten (PRE) i Eslöv parallellt med att författaren arbetade som klinisk psykolog vid enheten och utförde bedömningar av patienternas intellektuella/kognitiva förmåga och personlighet. Resultaten från dessa bedömningar kom tillsammans med andras bedömningar att utgöra underlaget för den individuella vårdpThese studies were conducted at the Psychiatric Rehabilitation Unit (PRU), characterised by a supportive ego-strenghtening psychodynamic approach. The general aim of the thesis was to study how intellectual ability and perceived self-image were related to perceived ward atmosphere among patients with psychosis. The first study described how patients and staff perceived the ward atmosphere at five

Lund Eye Tracking Studies in Research on Language and Cognition

The research group from Humanities laboratory at Lund University, Sweden, presents three strands of research on language and cognition where eye-tracking methodology has been used as a window on the mind. The paper includes: (1) eye tracking studies on picture viewing and picture description showing the dynamics of how speakers perceive, conceptualize and spontaneously describe complex visual scen

Restricted cortical and amygdaloid removal of vesicular glutamate transporter 2 in preadolescent mice impacts dopaminergic activity and neuronal circuitry of higher brain function

A major challenge in neuroscience is to resolve the connection between gene functionality, neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a glutamatergic component, the nature of which has been difficult to assess because of the vast cellular abundance of glutamate. In this study, we wanted to determine the role of a restricted subpopulation of glut

Cost-effective Passive House renovation packages for Swedish single-family houses from the 1960s and 1970s

This paper evaluates the cost-effectiveness of renovating single-family houses to Passive House level, as compared to maintaining the existing buildings or renovating to building regulation level. The assessment involved life cycle cost analyses, and concerns the Swedish single-family housing stock constructed between 1961 and 1980, which accounts for about a third of Sweden’s two million single-f

Multiple Forms of Endocannabinoid and Endovanilloid Signaling Regulate the Tonic Control of GABA Release

UNLABELLED: Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration of neurotransmitter release probability. To address this questi

Palladium(II) Halide Complexes I. Stabilities and Spectra of Palladium(II) Chloro and Bromo Aqua Complexes

Stability constants, βn, n = 1, 2, 3, 4, for the chloro and bromo complexes of palladium(II) have been calculated, using a least squares programme, from spectrophotometric measurements at 222, 234.5 and 279 nm (chloride) and at 247, 265, and 332 nm (bromide). The following values of lg(βn/M−n) were obtained: 4.47±0.01, 7.76±0.04, 10.17±0.07, and 11.54±0.09 (chloride) and 5.17±0.02, 9.42±0.04, 12.7

Effekten av en accelerationsrådgivare. Analys ur ett bränsle-, emissions- och förarperspektiv baserat på körningar med postbilar

Fordonens körmönster, dvs hastighets- och accelerationsmönster påverkar mängden utsläpp i hög grad. I tidigare studier har parametern andel kraftig acceleration (a>1,5m/s2) visat sig ha en signifikant effekt framför allt för avgasutsläpp av NOx och HC men även för bränsleförbrukningen. Ett förarstöd som styr accelerationen kan därmed ha en positiv effekt för att minska emissioner och bränsleförbru

Cyclin A1 expression and associations with disease characteristics in childhood acute lymphoblastic leukemia.

A critical cell cycle regulatory protein, cyclin A1, has been implicated in the development of acute myeloid leukemia (AML). Here, we have examined the expression and clinical significance of cyclin A1 in childhood acute lymphoblastic leukemia (ALL). Cyclin A1 was highly expressed in lymphoblastic leukemic cell lines and in 22 of 30 ALL patients (73%). Cyclin A1 expression correlated with patient