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Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and which cell types support neurons, we have
Anestesiläkare rapporterades i en svensk studie ha en högre mortalitet än genomsnittet av läkare. Detta fynd har dock ej kunnat reproduceras i motsvarande studier i de övriga nordiska länderna. Likväl har det spekulerats i om den angivna överrisken bland svenska anestesiläkare kan relateras till gruppens jourarbete med höga krav, nattarbete och stress. Kunskapen om hälsoeffekter av läkares jourarb
The advent of Java and similar languages on the real-time system scene necessitates the development of efficient strategies for scheduling the work of a garbage collector in a non-intrusive way. We propose a scheduling strategy, time-triggered garbage collection, based on assigning the collector a deadline for when it must complete its current cycle. We show that a time-triggered CC with fixed dea
Abstract in UndeterminedThis article presents an integrated environment for application scheduling, binding and routing used for the run-time reconfigurable, operator based, ROMA multimedia architecture. The environment is very flexible and after a minor modification can support other reconfigurable architectures. Currently, it supports the architecture model composed of a bank of single (double)
A business analyst who commences an investigation into design requirements for a new work system probably does not ‘label’ her inquiry process as research. However, a research perspective is needed if a productive learning spiral is to be established in which ‘useful’ systems can be created. Systematic, collaborative inquiry adopting an complex, open systems perspective is required in order to est
One factor which can be expected to influence performance in applications where the user is expected to point a device in some direction to obtain information is the angle interval in which the user gets feedback. The present study was performed in order to get a better understanding of the influence of this angle interval on navigation performance, gestures and strategies in a more realistic outd
We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and th
We have studied a selection of factors influencing the damage of DNA in nanochannels during fluorescence imaging. For cutting and nicking of DNA we show that the DNA is shortened during imaging. To avoid photodamage over the course of several hours of a typical experiment, we demonstrate the importance of an oxygen free gas to propel the buffer solution through the device. Finally, by varying the
Many ships today rely on Global Navigation Satellite Systems (GNSS), for their navigation, where GPS (Global Positioning System) is the most well-known. Unfortunately, the GNSS systems make the ships dependent on external systems, which can be malfunctioning, be jammed or be spoofed. There are today some proposed techniques where, e.g., bottom depth measurements are compared with known maps using
We present a new experimental method for the measurement of the compressibility of cells by analysis of free flow acoustophoresis separation data.
We report a new method to select the optimal actuation frequencies in bulk acoustophoresis devices, by means of differential impedance spectrum analysis measured via the actuating piezoelectric transducer (piezo). The impedance spectra is rich of large spurious resonance peaks originating from bulk resonances not related to the channel resonance, Fig. 1a, why direct measurement of the piezo impeda
The “neurotrophic hypothesis of depression” posits that low levels of brain-derived neurotrophic factor (BDNF) are associated with Major Depressive Disorder (MDD). Low levels of BDNF have also been found in individuals with suicide attempts, in MDD or other disorders, suggesting that low BDNF may also be associated with suicidality. We assessed serum BDNF in 68 physically healthy and unmedicated (
During March 2020 a large-span arena, Tarfalahallen, collapsed. The main load-bearing girders with a 54 m span were high and slender glulam trussed beams, supported from below by a cable system via vertical struts. Investigations concluded that the failure was initiated by out-of-plane buckling of the struts and slender beam, in spite of lateral stabilization by steel roof sheeting at the top edge
This work presents an acoustofluidic chip capable of separating cells form their corresponding secretome for subsequent MALDI-MS analysis, which can be used amongst many other applications for directed evolution.
Square Kilometer Array (SKA) is a project aimed to build the largest radio telescope in the world and it has just gotten into the construction phase. In this phase, the ability to develop and integrate software in an integration environment is crucial as it is the ability to visualize system-related information via a User Interface to rapidly verify the correctness of the system behavior and spot
In the present study, we apply deterministic chaos theory to investigate nonlinear dynamics in monthly precipitation at Mokpo, Korea, after wavelet decomposition. The wavelet transform is used not only for removal of noise but also for extraction of low and high frequency components in the data, representing low-dimensional dynamics. In order to determine an appropriate decomposition level for the
