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Embryonic nigral grafts can survive, reinnervate the striatum and reverse functional deficits in both experimental and clinical Parkinsonism. A major drawback is that only around 10% of the implanted dopaminergic neurons survive. The underlying mechanisms leading to this 90% cell death are not fully understood, but oxidative stress and a substantial loss of neurotrophic support are likely to be in
BACKGROUND: Anal sphincter rupture is a serious complication of vaginal delivery and almost half the affected women have persistent defecatory symptoms despite adequate primary repair. During the past decade, the incidence of anal sphincter ruptures has been increasing in Sweden and is currently estimated to occur in 2.5% of vaginal deliveries. The aim of the study was to report the frequency of a
Hyaluronic acid (HA) has been shown to affect angiogenesis and the function of the blood-brain barrier, and a crucial role for HA in atherosclerosis has been described. We have recently demonstrated changes in the levels of HA in cerebrospinal fluid (CSF) in patients with Alzheimer's disease (AD) with documented vascular alterations. To further investigate if the level of HA in CSF can be used as
Previous studies have suggested that amplification of genes, notably the TOP2A gene, on chromosome arm 17q may be important for the development of malignant peripheral nerve sheath tumour (MPNST). In order to study the frequency, distribution, and chromosomal organization of rearrangements at 17q, interphase and metaphase fluorescence in situ hybridization (FISH) were used to evaluate copy number
The first Scandinavian protocol for Ewing's sarcoma, SSG IV, resulted in a local control rate of 74% and 5-year metastasis-free survival (MFS) of 43%. The second protocol, SSG IX, was started in order to improve upon these results. It featured four chemotherapy cycles, each consisting of two courses of VAI (vincristine, doxorubicin, ifosfamide) alternating with one course of PAI (cisplatin, doxoru
Patients with rheumatoid arthritis (RA) and other inflammatory joint disorders (IJD) have increased cardiovascular disease (CVD) risk compared with the general population. In 2009, the European League Against Rheumatism (EULAR) taskforce recommended screening, identification of CVD risk factors and CVD risk management largely based on expert opinion. In view of substantial new evidence, an update
Background: We have developed a rapid method, based on lamellar body counts (LBC) on gastric aspirate, for identifying newborns who will develop respiratory distress syndrome with a need for surfactant supplementation. Objective: We set out to test whether it was possible to improve the outcome when used in a clinical trial. Methods: We randomly assigned 380 infants born at 24-29 weeks' gestation
Receptor tyrosine kinases (RTKs) are implicated in cardiovascular growth and remodelling. We aimed to identify the plasma levels of RTKs and related proteins and their association with haemodynamic alterations in heart failure (HF) and related pulmonary hypertension (PH) following heart transplantation (HT). Using proximity extension assay, 28 RTKs and related proteins were analysed in plasma from
Homework is widely used in most schools across the world to complement classroom teaching, increase knowledge retention, and foster good study habits. The research on the effect of homework assignment on student achievement is, however, inconclusive with earlier research indicating a positive relationship and newer studies giving a more nuanced picture. This thesis uses data from the 2019 wave of
Background: Fetal cardiovascular magnetic resonance (CMR) imaging may provide a valuable adjunct to fetal echocardiography in the evaluation of congenital cardiovascular pathologies. However, dynamic fetal CMR is difficult due to the lack of direct in-utero cardiac gating. The aim of this study was to investigate the effectiveness of a newly developed Doppler ultrasound (DUS) device in humans for
High-grade serous ovarian cancer (HGSOC) is the most lethal subtype of ovarian cancer and remains a major clinical challenge due to frequent late diagnosis and limited treatment options. This study investigates the therapeutic potential of targeting the oncogenic interaction between metadherin (MTDH) and staphylococcal nuclease domain-containing 1 (SND1) which are proteins known to promote tumor p
Dead wood is a key element in forest ecosystems and a wide range of organisms are dependent on this substrate for development and reproduction. Saproxylic beetles are important decomposers of dead wood and serve as food for many organisms. Due to the significant forestry-related decrease of dead wood in rural areas, many species of saproxylic beetles are considered threatened. Thus, other spaces h
Introduction: The standard therapy for exocrine pancreatic insufficiency (EPI) is porcine-derived pancreatic enzyme replacement therapy (PERT). In the present study we tested a new approach with a mixture of pancreatic- like enzymes of microbial origin (PLEM) in a 1-week efficacy study in EPI pigs. In addition to the conventionally used coefficient of fat and nitrogen absorption (CFA and CNA), par
Samhällsgeografi – SGEA20, Delkurs 2, VT 2018 Tre globala utmaningar – resurser, miljö och ekonomi (7,5 hp) Lärare: MG=Markus Grillitsch // EJ = Erik Jönsson (kursansvarig) // YM=Yahia Mahmoud Lokaler: Världen (vån 1), Malmö (vån 4), Flygeln (vån 1), Utopia (vån 3) alla på Geocentrum 1 15/2 8-10 Vär. Globala utmaningar, en introduktion EJ 16/2 10-12 Vär. Naturen som idé och ideologisk grundval EJ
https://www.keg.lu.se/sites/keg.lu.se/files/sgea20_2_schema_vt2018.pdf - 2026-06-02
Towards Sustainable Menstrual Health Management in Tanzania POLICY BRIEF FROM LUND UNIVERSITY CENTRE FOR SUSTAINABILITY STUDIES | 2018 POLICY BRIEF For any girl or woman in the world periods can be a struggle. In Tanzania, lack of hygiene products and potable water, sanitation facilities and waste collec- tion systems, along with deeply rooted taboos makes the menstrual cycle even harder. Poor Men
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/policy_brief_mhm_saragabrielsson.pdf - 2026-06-02
