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We aimed to determine the relationship between handgrip strength, smoking, and alcohol consumption in young men and fracture risk at middle age. Thus, we carried out a cohort study including young men undergoing conscription examination in Sweden from September 1969 to May 1970 at a typical age of 18 years. Data on muscle strength, height, weight, and lifestyle factors were linked to the National

Due to their stable fluorescence, biocompatibility, and amenability to functionalization, fluorescent nanodiamonds (FND) are promising materials for long term cell labeling and tracking. However, transporting them to the cytosol remains a major challenge, due to low internalization efficiencies and endosomal entrapment. Here, nanostraws in combination with low voltage electroporation pulses are us

Along with the rapid development of cloud computing technology, containerization technology has drawn much attention from both industry and academia. In this paper, we perform a comparative measurement analysis of Docker-sec, which is a Linux Security Module proposed in 2018, and a new AppArmor profile generator called Lic-Sec, which combines Docker-sec with a modified version of LiCShield, which

Adoptive T-cell therapy (ACT) is a highly intensive immunotherapy regime that has yielded remarkable response rates and many durable responses in clinical trials in melanoma; however, 50-60% of the patients have no clinical benefit. Here, we searched for predictive biomarkers to ACT in melanoma. Whole exome-and transcriptome sequencing and neoantigen prediction were applied to pre-treatment sample

Low trap-state density, high carrier mobility, and efficient charge carrier collection are key parameters for photodetectors with high sensitivity and fast response time. This study demonstrates a simple solution growth method to prepare CsPbBr3 microcrystals (MCs) with low trap-state density. Time-dependent photoluminescence study with one-photon excitation (OPE) and two-photon excitation (TPE) i

Background: Atrial fibrillation (AF) is a known risk factor for ischemic stroke. Electrocardiographic predictors of AF in population studies such as the Framingham Heart Study, as well as in hypertensive patients have demonstrated a predictive value of the P-wave duration for development of AF. QRS vector magnitude has had a predictive value in ventricular arrhythmia development. We aimed to asses

This paper examines the linkages between cash-crop income and other dimensions of poverty to interrogate assumptions regarding the relationship between agricultural income and poverty alleviation. The analysis treats poverty as a multi-dimensional and socially disaggregated phenomenon. The paper employs a mixed methods approach to case studies of Ghana and Ethiopia to explore two critical issues.

The human immunoglobulin heavy-chain (IGH) locus is exceptionally polymorphic, with high levels of allelic and structural variation. Thus, germline IGH genotypes are personal, which may influence responses to infection and vaccination. For an improved understanding of inter-individual differences in antibody responses, we isolated SARS-CoV-2 spike-specific monoclonal antibodies from convalescent h

This paper presents and discusses the methodology and technical aspects of mechanical tests carried out at a wide strain rate range with simultaneous synchrotron X-ray diffraction measurements. The motivation for the study was to develop capabilities for in-situ characterization of the loading rate dependency of mechanically induced phase transformations in steels containing metastable austenite.

Venom is a key evolutionary trait, as evidenced by its widespread convergent evolution across the animal kingdom. In an escalating prey-predator arms race, venoms evolve rapidly to guarantee predatory or defensive success. Variation in venom composition is ubiquitous among snakes. Here, we tested variation in venom activity on substrates relevant to blood coagulation among Pseudonaja (brown snake)

Over recent years, there has been a rapid development of membrane-mimetic systems to encapsulate and stabilize planar segments of phospholipid bilayers in solution. One such system has been the use of amphipathic copolymers to solubilize lipid bilayers into nanodiscs. The attractiveness of this system, in part, stems from the capability of these polymers to solubilize membrane proteins directly fr

We investigate how frontline employees manage their emotional experiences of organizational event stigma as an implication of organizational wrongdoing. Our research is based on a longitudinal case study of Danske Bank, which was involved in a money laundering scandal of historical magnitude. We evoke Goffman’s epistemological understanding of stigma as arising in social interactions in all aspect

Open access to information is now a universal phenomenon thanks to rapid technological developments across the globe. This open and universal access to information is a key value of democratic societies because, in principle, it supports well-informed decision-making on individual, local, and global matters. In practice, however, without appropriate readiness for navigation in a dynamic informatio

Previous studies have shown that belief in the healthiness of organic food is a strong motive for buying organic. Typically, a positive relation between a nutritionally balanced diet (with respect to fruit, vegetables and meat) and organic consumption is also found. As market shares of organic food are much smaller than those of conventional food, consumers may face a trade-off between buying orga

Background: Chiropractic maintenance care (MC) has been found to be effective for patients classified as dysfunctional by the West Haven-Yale Multidimensional Pain Inventory (MPI). Although displaying good psychometric properties, the instrument was not designed to be used in clinical practice to screen patients for stratified care pathways. The aim was to develop a brief clinical instrument with

PurposeTo analyse structural characteristics of malformations of cortical development (MCD) at 7T and 3T MRI.MethodsTwenty-five patients were examined with a 7T MRI-scanner in addition to 3T examinations performed for epilepsy evaluation. 7T sequences included a 3D-T1-weighted (T1w) MPRAGE, 3D-T2w FLAIR, and heavily T2w axial and coronal high-resolution (0.5×0.5×0.75-1.0 mm3) 2D-TSE sequences. Ima

The current way of consumption and production is unsustainable in that society is exceeding the earth’s planetary boundaries and creating long-term and irreversible effects on an environmental, social, and economic level. There is a recognized need on all system levels to change the way that we operate. Industry is a key area that requires this attention, as it is largely responsible for the impac

This communication describes a two unit antisense RNA cassette system for use in gene silencing. Cassettes consist of a recognition unit and an inhibitory unit which are transcribed into a single RNA that carries sequences of non-contiguous complementarity to the chosen target RNA. The recognition unit is designed as a stem-loop for rapid formation of long- lived binding intermediates with target

BACKGROUND: Tuberculosis remains a leading infectious cause of death in resource-limited settings. Effective treatment is the cornerstone of tuberculosis control, reducing mortality, recurrence and transmission. Supporting treatment adherence through facility-based observations of medication taking can be costly to providers and patients. Digital adherence technologies (DATs) may facilitate treatm

Abstract Oil rich states all over the world share a common feature. They are less likely than other states, depending on other resources, to be ruled democratically. In this essay Saudi Arabia has been studied with the purpose of trying to find which mechanisms that lie behind why oil rich states do not have institutions or institutional change that promotes democracy. Saudi Arabia has the world