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Kick back and destroy the ride: Alcohol-related violence and associations with drinking patterns and delinquency in adolescence

AIM: To assess how drinking patterns and delinquency are associated with self-reported experiences of alcohol-related violence in an adolescent population. POPULATION AND RESEARCH DESIGN: Cross-sectional data were acquired from the Scania drug use survey 2005, consisting of 3847 students in 9th grade. Abstainers were omitted and 1873 responses analyzed, with binary and multi-variable logistic regr

Genetic variants in IL15 associate with progression of joint destruction in rheumatoid arthritis: a multicohort study

Background Interleukin (IL)-15 levels are increased in serum, synovium and bone marrow of patients with rheumatoid arthritis (RA). IL-15 influences both the innate and the adaptive immune response; its major role is activation and proliferation of T cells. There are also emerging data that IL-15 affects osteoclastogenesis. The authors investigated the association of genetic variants in IL15 with t

Chondroitin sulfate proteoglycans and microglia prevent migration and integration of grafted Muller stem cells into degenerating retina

At present, there are severe limitations to the successful migration and integration of stem cells transplanted into the degenerated retina to restore visual function. This study investigated the potential role of chondroitin sulfate proteoglycans (CSPGs) and microglia in the migration of human Muller glia with neural stem cell characteristics following subretinal injection into the Lister hooded

Effects of diabetes on neurotransmission in rat vaginal smooth muscle

The aim of this work was to characterize the effect of experimental diabetes on neurotransmission in rat vagina. Female Sprague-Dawley rats were divided into two groups: non-diabetic controls (NDM, n=38) and diabetics (DM, n=38). DM was produced by intraperitoneal injection of streptozotocin. Eight weeks later the animals were killed, the distal part of the vagina was removed, and smooth muscle st

Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics

Aims: To establish a cardiac cell culture model for simulated ischemia and reperfusion and in this model investigate the impact of simulated ischemia and reperfusion on expression of the calcium handling proteins FKBP12 and FKBP12.6, and intracellular calcium dynamics. Methods: HL-1 cell cultures were exposed to normoxia (as control), hypoxia, simulated ischemia (HEDA) or HEDA + reactive oxygen sp

Infections as a stimulus for coronary occlusion, obstruction, or acute coronary syndromes.

BACKGROUND: : Atherosclerosis is considered to be an inflammatory disease. Infections are a significant cause of inflammation. Acute infections might precipitate acute coronary syndromes (ACS) whereas chronic infections might be stimuli for the development of atherosclerosis. METHODS: : Coronary angiograms were done on 211 of 335 patients with ACS and the percentage of coronary obstruction was det

Vinegar dressing and cold storage of potatoes lowers postprandial glycaemic and insulinaemic responses in healthy subjects

Objective: To investigate the effects of cold storage and vinegar addition on glycaemic and insulinaemic responses to a potato meal in healthy subjects. Subjects and setting: A total of 13 healthy subjects volunteered for the study, and the tests were performed at Applied Nutrition and Food Chemistry, Lund University, Sweden. Experimental design and test meals: The study included four meals; fresh

An activity quantification method based on registration of CT and whole-body scintillation camera images, with application to 131I.

This article presents a new method for conjugate view activity quantification for 131I-labeled monoclonal antibody distribution. METHODS: The method is based on the combined use of images from 3 modalities: whole-body (WB) scintillation camera scanning, WB transmission scanning using 57Co, and CT. All images are coaligned using a recently developed program for the registration of WB images. Correc

Seeking evidence that cell kill guided thermotherapy gives results not inferior to those of transurethral prostate resection: Results of a pooled analysis of 3 studies of feedback transurethral microwave thermotherapy

Purpose: We compared ProstaLund Feedback Treatment(R) (PLFT(R)) to transurethral prostate resection (TURP) in terms of efficacy and safety in a pooled analysis of 3 clinical studies with 1-year followup. Materials and Methods: Overall raw data on 183 patients with PLFT(R) and 65 with TURP were pooled. All studies had identical inclusion criteria, and the efficacy and safety of the method were eval

Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism

Gas chromatography/mass spectrometry-based metabolomics was applied to investigate dynamic changes in the plasma metabolome upon an oral glucose tolerance test (OGTT). The OGTT is a frequently used diagnostic test of glucose homeostasis and diabetes. Diabetes is diagnosed either when glucose levels a parts per thousand yen7.0 mM in the fasting state or a parts per thousand yen11.0 mM at 2 h after

Reduced Irregularity of Ventricular Response During Atrial Fibrillation and Long-term Outcome in Patients With Heart Failure.

Reduced heart rate variability (HRV) is associated with poor outcome in patients with heart failure (HF). However, the data on predictive value of RR variability during atrial fibrillation (AF) are limited. Therefore, the aim of this study was to evaluate the association between ventricular response characteristics and long-term clinical outcome in the population of ambulatory patients with mild-t

Intensive agriculture reduces soil biodiversity across Europe

Soil biodiversity plays a key role in regulating the processes that underpin the delivery of ecosystem goods and services in terrestrial ecosystems. Agricultural intensification is known to change the diversity of individual groups of soil biota, but less is known about how intensification affects biodiversity of the soil food web as a whole, and whether or not these effects may be generalized acr

Targeting HMG-CoA reductase with statins in a window-of-opportunity breast cancer trial.

Lipophilic statins purportedly exert anti-tumoral effects on breast cancer by decreasing proliferation and increasing apoptosis. HMG-CoA reductase (HMGCR), the rate-limiting enzyme of the mevalonate pathway, is the target of statins. However, data on statin-induced effects on HMGCR activity in cancer are limited. Thus, this pre-operative study investigated statin-induced effects on tumor prolifera

Experimental studies on treatment of pancreatic cancer with double-regulated duplicative adenovirus AdTPHre-hEndo carrying human endostatin gene

Background: Gene-virus targeted therapy is a promising new method of treating pancreatic cancer. To increase the efficacy and decrease the side-effect, we constructed a conditionally replicative adenovirus (CRAd) expressing human endostatin, with a human Telomoerase Reverse Transcriptase (hTERT) promoter for the regulation of the early stage of adenovirus expression of gene E1a and a Hypoxia Respo

Cardiotocography only versus cardiotocography plus ST analysis of fetal electrocardiogram for intrapartum fetal monitoring: a Swedish randomised controlled trial

BACKGROUND: Previous studies indicate that analysis of the ST waveform of the fetal electrocardiogram provides information on the fetal response to hypoxia. We did a multicentre randomised controlled trial to test the hypothesis that intrapartum monitoring with cardiotocography combined with automatic ST-waveform analysis results in an improved perinatal outcome compared with cardiotocography alon

Neuroblastoma Cell Differentiation: The Role of Neurotrophin Receptor Signaling and N-myc Expression

Popular Abstract in Swedish Neuoroblastom är en av de tumörformer som oftast drabbar små barn. Eftersom tumörer lyckligtvis är relativt ovanliga hos barn drabbas inte fler än i genomsnitt 14 barn årligen av neuroblastom i Sverige. Tyvärr finns dock, trots den effektiva behandling som kunnat arbetas fram för många andra barncancerformer, idag ingen verksam behandling att tillgå för så många som hälNeuroblastoma is a tumor of sympathetic nervous system derivation, mostly afflicting young children. This thesis is focused on a group of receptor proteins for neurotrophic factors, the Trk family, and on N-Myc, a transcription factor, all important in the formation of the sympathetic nervous system as well as in determining neuroblastoma patient outcome. Expression of trkA and trkC is linked to f

Effects of Denervation and Infravesical Obstruction in the Rat Urinary Bladder

Popular Abstract in Swedish Råttans urinblåsa har studerats ur olika aspekter, sedan antingen ett standardiserat avflödeshinder åstadkommits eller hälften av urinblåsans nervförsörjning avlägsnats. Avflödeshindret har åstadkommits genom att en silkestråd knutits runtom urinröret så att det försnävats. Genom att en knappt mm-vid metallstav knutits om samtidigt och sedan avlägsnats, har graden av avMedian micturition volume decreased early after partial outlet obstruction, 24 hrs total obstruction and hemidenervation. Degeneration release of transmitter may explain this, assuming that bladder wall distension causes nerve degeneration. Micturition pressure decreased simultaneously in the partially denervated and 24 hrs obstructed groups, probably due to the reduced number of functionally inta

Dublinförordningen eller konsten att vara medmänniska - En analys av hur Dublinförordningen förhåller sig till mänskliga rättigheter

Uppsatsen undersöker hur Dublinförordningen förhåller sig till Europakonventionen, med fokus på artikel 8 om rätten till respekt för privatliv, familjeliv, hem och korrespondens. Dublinförordningen är det instrument i EU:s gemensamma asylsystem som bestämmer vilken medlemsstat som ska ansvara för att pröva en inkommen asylansökan. På senare år har mycket kritik riktats mot Dublinförordningen p.g.aThe essay examines how the Dublin Regulation relates to the European Convention on human rights, focusing on Article 8 on the right to respect for privacy, family life, home and correspondence. The Dublin Regulation is the instrument of the EU's Common Asylum System, which determines which Member State will be responsible for examining an asylum application. In recent years, much criticism has

Lojalitet och de svenska bankerna: En kvantitativ studie om vad som driver kundlojalitet på den svenska bankmarknaden idag

Examensarbetets titel: Lojalitet och de svenska bankerna - En kvantitativ studie om vad som driver svenska bankkunders lojalitet Seminariedatum: 12 januari 2017 Ämne/kurs: FEKH29, Business Administration: Degree Project in Marketing Undergraduate Level, 15 högskolepoäng. Författare: Emelie Nortén, Caroline Lindberg Hansen, Jacob Gustafsson Handledare: Johan Jansson Nyckelord: lojalitet, e-lojTitle: Loyalty and the Swedish banks – a quantitative study on what drives loyalty among Swedish online bank customers Seminar date: January 12, 2017 Course: FEKH29, Business Administration: Degree Project in Marketing Undergraduate Level, 15 credits Authors: Emelie Nortén, Caroline Lindberg Hansen, Jacob Gustafsson Advisor: Johan Jansson Key words: loyalty, e-loyalty, bank, online, service q