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Germline heterozygous variants in genes associated with familial hemophagocytic lymphohistiocytosis as a cause of increased bleeding

Familial hemophagocytic lymphohistiocytosis (FHL) is caused by biallelic variants in genes regulating granule secretion in cytotoxic lymphocytes. In FHL3–5, the affected genes UNC13D, STX11 and STXBP2 have further been shown to regulate the secretion of platelet granules, giving rise to compromised platelet function. Therefore, we aimed to investigate platelet degranulation in patients heterozygou

Coordination Complexes of Molybdenum with 3,6-Di-tert-butylcatechol. Addition Products of DMSO, Pyridine N-oxide, and Triphenylarsine Oxide to the Putative [MoVIO(3,6-DBCat)2] Monomer and Self-Assembly of the Chiral [{MoVIO(3,6-DBCat)2}4] Square

Molybdenum complexes of 3,6-di-tert-butylcatechol have been prepared from the reaction between [Mo(CO)6] and 3,6-di-tert-butyl-1,2-benzoquinone. A putative "[MoO(3,6-DBCat)2]" monomer is assumed to form initially by reaction with trace quantities of oxygen. Condensation of the reaction mixture leads to the formation of oligomeric products, including the [{MoO(3,6-DBCat)2}4] chiral square isolated

Kp SMMX25 eng VT25 rev 240830

Syllabus SMMX25 Sustainable Supply Chain Management This is a translation of the syllabus which was established in Swedish. STYR 2024/2165 Faculty of Social Sciences SMMX25, Sustainable Supply Chain Management, 7.5 credits Hållbara försörjningskedjor, 7,5 högskolepoäng Second Cycle / Avancerad nivå Details of approval The syllabus was approved by the board of the Department of Service Management a

https://www.ses.lu.se/en/sites/ses.lu.se.en/files/2024-09/Kp_SMMX25_eng_VT25_rev_240830.pdf - 2026-05-01

Post-Deleuzian Investigations of U.S. Avant-Garde Film, 1943–81

The aim of this dissertation is to investigate a number of U.S. avant-garde films using Deleuzian film-philosophy in order to describe their thought. I develop the taxonomy of cinematic images created by the French philosopher Gilles Deleuze by introducing a new type of image. The notion of the sobjective image I conceptualize points to the immanent semiosis that characterizes certain films. The s

The image of Giordano Bruno

One excuse for not making use of the visual sources is the difficulty in interpreting them. Before the historian can even try to make valid use of an image, he has to know what he is looking for, when and for what purpose it was made, in what circumstances, current visual conventions, technical and other constraints.1 Thus, extracting information from visual sources and combining it with literary

Parrondo’s Paradox and Epistemology – combining two faulty strategies to get good results

Parrondo’s Paradox and Epistemology – combining two faulty strategies to get good results PARRONDO’S PARADOX AND EPISTEMOLOGY – WHEN BAD THINGS HAPPEN TO GOOD COGNIZERS (AND CONVERSELY) Fredrik Stjernberg Philosophy, Linköping University frest@irk.liu.se ABSTRACT: According to Parrondo’s Paradox, there will be cases where a subject facing two probabilistically losing strategies has a probabilistic

https://www.fil.lu.se/hommageawlodek/site/papper/StjernbergFredrik.pdf - 2026-05-01

Soil carbon management in large-scale Earth system modelling: implications for crop yields and nitrogen leaching

Croplands are vital ecosystems for human well-being and provide important ecosystem services such as crop yields, retention of nitrogen and carbon storage. On large (regional to global)-scale levels, assessment of how these different services will vary in space and time, especially in response to cropland management, are scarce. We explore cropland management alternatives and the effect these can

Beyond Blueprints: Adoption of AI in Architecture

This thesis investigates the adoption of artificial intelligence (AI) solutions among architects in Sweden. Architects are currently experiencing headwinds and decreased demands for their services as increasing interest rates and a weak economy have contributed to a decline in construction activity. Simultaneously, advancements in AI have introduced a range of innovative technologies to the field

Evaldegprojbioinfo

eng Betygsunderlag Bioinformatik exjobb sep2016.xls Credits: The Project (primarily evaluated by the Supervisor) Grade 1-5 In your view, was this project intellectually demanding and required considerable amount of new knowledge to gain for the student? The Process (primarily evaluated by the Supervisor) Grade 1-5 1. Independence of the student. 2. Ability to carry out the project (knowledge and c

https://www.biologiutbildning.lu.se/sites/biologiutbildning.lu.se/files/2021-12/evaldegprojbioinfo.pdf - 2026-05-01

Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility.

Dysfunction in various parts of immune defence, such as immune response, immune complex clearance, and inflammation, has an impact on pathogenesis in systemic lupus erythematosus (SLE). We hypothesised that combinations of common variants of genes involved in these immune functions are associated with susceptibility to SLE. The following variants were analysed: HLA DR3, HLA DQ2, C4AQ0, Fcgamma rec

From policy to practice: progress towards data- and code-sharing in ecology and evolution

Data and code are essential for ensuring the credibility of scientific results and facilitating reproducibility, areas in which journal sharing policies play a crucial role. However, in ecology and evolution, we still do not know how widespread data- and code-sharing policies are, how accessible they are, and whether journals support data and code peer review. Here, we first assessed the clarity,

Fire

What to do in case of fire in the Biology or Ecology Buildings Know what to do!You must know in advance what to do if a fire breaks out in the building/buildings where you work. To find out, do this:Go out into the corridor and carefully study the evacuation plan available there.The evacuation plan will have information about:Firefighting equipment and alarm buttons. All firefighting equipment is

https://www.biology.lu.se/internal/employment/work-environment/fire - 2026-04-29

Expression, activity, and subcellular localization of testicular hormone-sensitive lipase during postnatal development in the guinea pig

The present work reports on testicular hormone-sensitive lipase (HSL), the biological significance of which has been documented in male fertility. The HSL protein levels and enzymatic activity were measured, respectively, by densitometry of immunoreactive bands in Western blots, performed with antibodies against recombinant rat HSL, and by spectrophotometry in seminiferous tubules (STf) and inters

Spatially coupled turbo-like codes : A new trade-off between waterfall and error floor

Spatially coupled turbo-like codes (SC-TCs) have been shown to have excellent decoding thresholds due to the threshold saturation effect. Furthermore, even for moderate block lengths, the simulation results demonstrate a very good bit error rate performance in the waterfall region. In this paper, we discuss the effect of spatial coupling on the performance of TCs in the finite block-length regime.