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Protein Complexity via Non-Native States: Binding, Stability, and Structural Studies of Calbindin D9k and HAMLET (Human alpha-lactalbumin Made LEthal to Tumor cells).

Popular Abstract in Swedish Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Det finns ofta en vattenmolekyl med på bindningsstället i proteinet och vi har studerat hur den påverkar bindningsegenskaperna. Kalcium är inblandat i många viktiga processer i kroppen. Kalciumbindande proteiner är viktiga i detta sammanhang. Jag har studeUsing optical spectroscopy, nuclear magnetic resonance (NMR), and differential scanning Calorimetry (DSC), I have studied two different calcium binding proteins that can form kinetically trapped altered states. Calcium is very important in numerous biological processes such as blood coagulation, signal transduction, muscle contraction and bone formation. Calcium binding to proteins regulates these

Surface Wave Testing of Pavements

A novel approach for surface wave testing of pavements is presented. It is a non-destructive testing (NDT) technique that can be used to obtain the thickness and stiffness properties of the different layers in a pavement. With this method structural properties of the pavement can be mapped as a function of time and space, providing a valuable tool in pavement design and management. The technical d

A critical analysis of the potential for EU Common Agricultural Policy measures to support wild pollinators on farmland

Agricultural intensification and associated loss of high-quality habitats are key drivers of insect pollinator declines. With the aim of decreasing the environmental impact of agriculture, the 2014 EU Common Agricultural Policy (CAP) defined a set of habitat and landscape features (Ecological Focus Areas: EFAs) farmers could select from as a requirement to receive basic farm payments. To inform th

Fibroblasts direct differentiation of human breast epithelial progenitors

Background: Breast cancer arises within specific regions in the human breast referred to as the terminal duct lobular units (TDLUs). These are relatively dynamic structures characterized by sex hormone driven cyclic epithelial turnover. TDLUs consist of unique parenchymal entities embedded within a fibroblast-rich lobular stroma. Here, we established and characterized a new human breast lobular fi

A dedicated flask sampling strategy developed for Integrated Carbon Observation System (ICOS) stations based on CO2 and CO measurements and Stochastic Time-Inverted Lagrangian Transport (STILT) footprint modelling

In situ CO2 and CO measurements from five Integrated Carbon Observation System (ICOS) atmosphere stations have been analysed together with footprint model runs from the regional Stochastic Time-Inverted Lagrangian Transport (STILT) model to develop a dedicated strategy for flask sampling with an automated sampler. Flask sampling in ICOS has three different purposes, namely (1) to provide an indepe

Cervical or thoracic anastomosis after esophageal resection and gastric tube reconstruction - A prospective randomized triol comparing sutured neck anastomosis with stapled intrathorocic anastomosis

Objective: The purpose of the study was to compare in prospective randomized fashion a manually sutured esophagogastric anastomosis in the neck and a stapled in the chest after esophageal resection and gastric tube reconstruction. Summary Background Data: Despite the fact that all reconstructions after esophagectomy will result in a cervical or a thoracic anastomosis, controversy still exists as t

Lecticans in Vascular Remodeling of the Pulmonary and Fetal Circulation : Implications for Children with End-Stage Heart Disease

Introduction: Elevated pulmonary vascular resistance (PVR) is observed in both physiological and pathological states. Pulmonary hypertension (PH) is a condition associated with significant morbidity and mortality in neonates and children and curative pharmacotherapy is lacking in most cases. In utero, a high PVR allows for blood to bypass the lungs through the open ductus arteriosus (DA). Vascular

Falls Predict Fractures Independently of FRAX Probability : A Meta-Analysis of the Osteoporotic Fractures in Men (MrOS) Study

Although prior falls are a well-established predictor of future fracture, there is currently limited evidence regarding the specific value of falls history in fracture risk assessment relative to that of other clinical risk factors and bone mineral density (BMD) measurement. We therefore investigated, across the three Osteoporotic Fractures in Men (MrOS) Study cohorts, whether past falls predicted

Integrated approach to investigate groundwater nitrate nitrogen pollution and remediation simulation in Shimabara Peninsula, Nagasaki, Japan

Groundwater is the general source of drinking water in the Shimabara Peninsula, Nagasaki, Japan, and consequently, occurring nitrate nitrogen (NO3-N) pollution in the groundwater is a significant problem. Although various countermeasures have been implemented, nitrate nitrogen concentrations remain serious. Therefore, it is necessary to evaluate effects of different potentially effective counterme

Savouring the sea: Production and consumption of future seaweed foods

Current food systems pose one of the greatest health and environmental challenges of the21st century. A systemic shift in the food sector can be accelerated by technologies and innovations,such as seaweed food applications. However, introducing and expanding seaweed as a food resourceinto Western markets comes with several challenges.These challenges include its microbial, chemical, and sensory qu

To continue or not to continue? Antipsychotic medication maintenance versus dose-reduction/discontinuation in first episode psychosis : HAMLETT, a pragmatic multicenter single-blind randomized controlled trial

Background: Antipsychotic medication is effective for symptomatic treatment in schizophrenia-spectrum disorders. After symptom remission, continuation of antipsychotic treatment is associated with lower relapse rates and lower symptom severity compared to dose reduction/discontinuation. Therefore, most guidelines recommend continuation of treatment with antipsychotic medication for at least 1 year

Nytt sätt för nedsövda patienter att förmedla smärta – Vetenskap och Hälsa

Nytt sätt för nedsövda patienter att förmedla smärta – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Nytt sätt för nedsövda patienter att förmedla smärta 2021-04-12 Foto: iStock/Sudok1 Mitt under pandemin har doktorand Mia Hylén på Malmö universitet forskat på smärtskattning på vuxna patie

https://www.vetenskaphalsa.se/nytt-satt-for-nedsovda-patienter-att-formedla-smarta/ - 2025-10-03

Peripheral inflammatory subgroup differences in anterior Default Mode network and multiplex functional network topology are associated with cognition in psychosis

Introduction: High-inflammation subgroups of patients with psychosis demonstrate cognitive deficits and neuroanatomical alterations. Systemic inflammation assessed using IL-6 and C-reactive protein may alter functional connectivity within and between resting-state networks, but the cognitive and clinical implications of these alterations remain unknown. We aim to determine the relationships of ele

Polycyclic aromatic hydrocarbons (PAHs) in men and lactating women in Slovenia : Results of the first national human biomonitoring

In the first national human biomonitoring study in the Slovenian population of adults (18–49 years), including men (n = 297) and lactating primiparous women (n = 304), exposure to polycyclic aromatic hydrocarbons (PAHs) was evaluated. Nine urinary metabolites of four parent PAHs were determined. These included 1-hydroxypyrene (1-OHPYR), 2-hydroxynaphthalene (2-OHNAP), 2-hydroxyphenanthrene (2-OHPH

The impact of human constructions on the areal extent of Italian Tuscany forests

Abstract Trying to preserve the forest is an important issue considering its tremendous impact on the ecosystem and subsequently on humans and their lives. On the other hand, humans have changed the area of the forest in different ways. Therefore, investigating the human impact and helping to prevent the destruction of the forest plays a vital role in preserving biodiversity and maintaining ecosys

Coordination of Phosphine-Thioether Ligands to Low-valent Metal Centers

The reactivity of the phosphine-thioether ligands bis(2-diphenylphosphino) ethylthio)ethane (PSSP), bis(2-(diphenylphosphino) ethyl)sulfane (PSP), PPh2CH2CH2SMe (PS), PPh2(o-C6H4SMe (PortoS), and PPh(o-C6H4SMe)2 (PSS) towards low-valent carbonyl clusters has been studied. In all structurally characterized clusters, the ligand donor atoms are terminally coordinated. The phosphine-thioether ligands

Experimental Adaptive Optics. A test facility for adaptive optics on a small telescope

Popular Abstract in Swedish Nästa år är det 400 år sedan Galileo Galilei för första gången riktade ett teleskop mot objekt på himlen. Allt sedan dess har teleskopet varit det viktigaste instrumentet för astronomins utveckling och med dess hjälp har vår kunskap om universum revolutionerats. Tack vare utvecklingen av teleskopet under dessa århundraden har allt ljussvagare objekt kunnat studeras, ochThis thesis presents the work on the design of, construction of, and finally observations with, an experimental setup comprising a small telescope equipped with adaptive optics. The facility has been assembled at Lund Observatory, where also observations on the sky have been made. The aim of this project was to gain hands-on knowledge in the development of a real adaptive optics system and eventua