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Mitochondrial disorders cause energy failure and metabolic derangements. Metabolome profiling in patients and animal models may identify affected metabolic pathways and reveal new biomarkers of disease progression. Using liver metabolomics we have shown a starvation-like condition in a knock-in (Bcs1lc.232A>G) mouse model of GRACILE syndrome, a neonatal lethal respiratory chain complex III dysfunc
Arsenic is a major contaminating heavy metal due to its frequent occurrence and toxicity. Out of different remediation approaches, bioremediation using bacteria has been extensively studied. In this study, 29 bacterial isolates were screened for their arsenic tolerance capacity. One of the isolate, MUM2 showed maximum arsenic tolerance (10mM). Antioxidant enzymes were assayed in this isolate under
Background Alveolar macrophages (AMFs) are critical regulators of lung function, and may participate in graft rejection following lung transplantation. Recent studies in experimental animals suggest that most AMFs are self-maintaining cells of embryonic origin, but knowledge about the ontogeny and life span of human AMFs is scarce. Methods To follow the origin and longevity of AMFs in patients wit
BACKGROUND: Exposure to inorganic arsenic (iAs) through drinking water causes cancer. Alterations in mitochondrial DNA copy number (mtDNAcn) and telomere length in blood have been associated with cancer risk. We elucidated if arsenic exposure alters mtDNAcn and telomere length in individuals with different arsenic metabolizing capacity.METHODS: We studied two groups in the Salta province, Argentin
OBJECTIVES: To estimate the rate of admissions to NICUs, as well as infants' morbidity and abs neonatal interventions, after exposure to antidepressant drugs in utero. METHODS: Data on pregnancies, deliveries, prescription drug use, and health status of the newborn infants were obtained from the Swedish Medical Birth Register, the Prescribed Drug Register, and the Swedish Neonatal Quality Register
Background: Domestic violence is a global health problem as well as a violation against human rights. The aim of this study was to explore prevalence and incidence of domestic violence during pregnancy and 1 to 1.5 years postpartum as well as to explore the history of violence among new mothers in the southwestern region of Sweden. In addition, the aim was to explore the association between domest
This book examines the ways in which universities can play a crucial role in inclusive development, social innovation and social entrepreneurship. It aims to prove the importance of inclusive development and inclusive innovation on economic growth and demonstrate the ways in which universities can be pioneers in this area through initiatives in social responsibility and social innovation. For exam
This chapter explores how universities in Sweden have approached the challenges of inclusive development and social innovation. Whereas the higher education system has been quite successful in providing access to previously excluded groups, the concept of social innovation applied to solving social problems has not yet been integrated into the policies and practices of the university innovation sy
Today, we can see a growing concern among governments, policy makers, donors and other stakeholders, that there is a mismatch between research (R&D) input and its results. Substantial amounts of money are spent on research facilities without a commensurate return on investment. For developed countries, it can be frustrating not getting the sought-after mileage of an investment in knowledge pro
Police crash reports are often the main source for official data in many countries. However, police sampling and data are known to be subject to bias, making the countermeasures adopted according to them possibly inefficient. In the case of bicycle crashes, this bias is most acute and it probably varies across countries, with some of them being more prone to reporting accidents to police than othe
Improved understanding of the impact of the operating conditions on the heat transfer and fluid flow behaviors of an outlet guide vane (OGV) is essential for accurate prediction of the lifetime of jet engines. In this article, the heat transfer characteristics of an OGV at various Reynolds numbers (Re), free stream turbulence levels, Mach number (Ma), and surface roughness are studied numerically.
Water-related impacts due to change in climatic conditions ranging from water scarcity to intense floods and storms are increasing in developing countries like Pakistan. Water quality and waterborne diseases like hepatitis, cholera, typhoid, malaria and dengue fever are increasing due to chaotic urbanization, industrialization, poor hygienic conditions, and inappropriate water management. The morb
In terrestrial ecosystems, a large portion (20-80%) of the dissolved Si (DSi) in soil solution has passed through vegetation. While the importance of this terrestrial Si filter is generally accepted, few data exist on the pools and fluxes of Si in forest vegetation and the rate of release of Si from decomposing plant tissues. We quantified the pools and fluxes of Si through vegetation and coarse w
Finite element modelling (FEM) is used to show that the addition of Au contacts to a single horizontal InAs/InP heterostructure nanowire substantially alters the nanowire's optical properties in comparison to the uncontacted case. It is found that the addition of contacts can increase absorption efficiency, decrease scattering efficiency and shift the location of absorption within the nanowire. Lo
Mesenchymal stromal cells (MSCs) harbor great therapeutic potential for numerous diseases. From early clinical trials, success and failure analysis, bench-to-bedside and back-to-bench approaches, there has been a great gain in knowledge, still leaving a number of questions to be answered regarding optimal manufacturing and quality of MSCs for clinical application. For treatment of many acute indic
ConspectusThe photophysics and photochemistry of transition metal complexes (TMCs) has long been a hot field of interdisciplinary research. Rich metal-based redox processes, together with a high variety in electronic configurations and excited-state dynamics, have rendered TMCs excellent candidates for interconversion between light, chemical, and electrical energies in intramolecular, supramolecul
Purpose – Evasive entrepreneurs innovate by circumventing or disrupting existing formal institutional frameworks. Since such evasions rarely go unnoticed, they usually lead to responses from lawmakers and regulators. The paper aims to discuss this issue. Design/methodology/approach – The authors introduce a conceptual model to illustrate and map the interdependencey between evasive entrepreneurshi
