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Standard treatment for glioblastoma (GBM) patients is surgery and radiochemotherapy (RCT) with temozolomide (TMZ). TMZ is a substrate for ABCB1, a transmembrane drug transporter. It has been suggested that survival for GBM patients receiving TMZ is influenced by different single-nucleotide variants (SNV) of ABCB1. We therefore examined SNV:s of ABCB1, namely 1199G>A, 1236C>T, 2677G>T/A, and 3435C>
Historik över rektorsämbetet vid Lunds universitet.
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proTo date, bone marrow-derived mesenchymal stromal cells (MSCs) have been considered the golden standard among MSC cell-based therapies. However, the harvesting of bone marrow is a highly invasive procedure and the number of MSCs isolated is low, and it declines with increasing age. MSCs with immune-regulatory and regenerative properties can be isolated from many different tissues; however, bone mar
Chronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies proChronic obstructive pulmonary disease (COPD) is a progressive life-threatening disease that is significantly increasing in prevalence and is predicted to become the third leading cause of death worldwide by 2030. At present, there are no true curative treatments that can stop the progression of the disease, and new therapeutic strategies are desperately needed. Advances in cell-based therapies pro
This article analyses the evolution of public support for the single European currency, the euro, from 1990 to 2014 for a 12-country sample of the euro area (EA-12), focusing on the most recent period of the financial and sovereign debt crisis, starting in 2008. We find that citizens’ support for the euro on average was marginally reduced during the first six years of the crisis, and that support
The objective of this dissertation is to investigate the narrative mechanisms and imagery that fictional works employ to conceptualize and communicate complex human experiences of space, time and memory. Furthermore, this study shows how contemporary cities change the way we think about such basic concepts by analyzing narratives that employ and encourage multisensory, spatiotemporal understanding
The aim of this article is to analyse how innovation policy is staged and legitimised through the dramatised social process of an event. The context is taken from an annual event, Skåne Innovation Week, which is arranged by the regional innovation system in Skåne, Sweden. Innovation systems often organise similar events internationally, which appear to play a key role in performing inter-organisat
Investment in railways, and transport infrastructure in general, are often motivated because they are believed to improve peoples’ accessibility to jobs. By linking together and increasing the size of labour markets, the matching between individuals and jobs is improved, and the productivity increases. Communities and municipalities lobby for investments that lead to higher accessibility and those
The similarity of in-situ and ex-situ absorption/extinction properties was found by comparing data sets obtained in premixed flat ethylene flames (C/O = 0.77); both ex-situ absorption measurements at CNR of Naples and in-situ laser extinction/absorption measurements at Lund University. The optical band gap analysis was performed as a method to separate/evaluate the contributions to the UV–Visible
Stellar ages are a crucial component to studying the evolution of the Milky Way. Using Gaia DR2 distance estimates, it is now possible to estimate stellar ages for a larger volume of evolved stars through isochrone matching. This work presents [M/H]-age and [α/M]-age relations derived for different spatial locations in the Milky Way disc. These relations are derived by hierarchically modelling the
The chemical compositions of stellar atmospheres reflect the interstellar gas from which they formed, each one containing a snapshot of the Milky Way Galaxy's chemical evolution. By comparing abundances of stars across the disk of our Galaxy, we can explore how different parts of the Galaxy were enriched, where star formation proceeded most rapidly, and whether there has been significant mixing of
In the age of high-resolution spectroscopic stellar surveys of the Milky Way, the number of stars with detailed abundances of multiple elements is rapidly increasing. These elemental abundances are directly influenced by the evolutionary history of the Galaxy, but this can be difficult to interpret without an absolute timeline of the abundance enrichment. We present age-abundance trends for [M/H],
We present a sample of 705 local giant stars observed using the New Mexico State University 1 m telescope with the Sloan Digital Sky Survey-III/Apache Point Observatory Galactic Evolution Experiment (APOGEE) spectrograph, for which we estimate stellar ages and the local star formation history (SFH). The high-resolution (R ̃ 22,500), near infrared (1.51-1.7 μm) APOGEE spectra provide measurements o
We present new BVI photometry containing 40,000 stars of the Galactic globular cluster M15 (NGC 7078) covering a 25×25 arcminute area centered on the cluster with a magnitude range from the tip of the Red Giant Branch to three magnitudes below the main sequence turn-off. Using α -enhanced Dartmouth Stellar Evolution Program models, we find an age of 13.0 ± 1.0 Gyr and distance modulus of (
As a follow-up of a previous investigation in which semisynthetic damsin derivatives were shown to possess up to 10 times higher cytoxicity in JIMT-1 breast cancer cells compared to normal breast epithelial MCF-10A cells, a range of new derivatives were prepared and assayed toward the same cells. Damsin, a natural plant metabolite containing a α-methylene-γ-lactone (or 3-methylenedihydro- furan-2(
