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Pancreatic cancers are associated with poor survival and only some 10 per cent are resectable, but even in this subgroup recurrence is very frequent. The traditional view of sequential development of pancreatic cancer has been challenged by novel molecular biological findings, where the tumor quite rapidly might turn metastatic. In about 60 000 patients with diagnosed pancreatic cancer the associa
Severe alpha-1-antitrypsin (AAT) deficiency (PiZZ) is a risk factor for liver disease, but the prevalence of liver cirrhosis and hepatocellular cancer in PiZZ adults is unknown. The risk of liver disease in adults with moderate AAT deficiency (PiSZ) is also unknown. A cohort of 127 PiZZ, 2 PiZnull, 54 PiSZ, and 1 PiSnull individuals were identified by the Swedish national neonatal AAT screening pr
The gas diffusion layer is an anisotropic porous medium, which provides pathways for the reactant gases and produced water, conducts the electrical current, removes the generated heat, and provides mechanical support. However, the gas diffusion layer is mostly considered as isotropic in numerical simulations. In the present study, a three-dimensional, two-phase flow, and non-isothermal agglomerate
Collaboration between modellers and experimentalists is essential in ecological research, however, different obstacles linking both camps often hinder scientific progress. In this commentary, we discuss several issues of the current state of affairs in this research loop. Backed by an online survey amongst fellow ecologists, modellers and experimentalists alike, we identify two major areas that ne
Magnetization Transfer Contrast (MTC) and Chemical Exchange Saturation Transfer (CEST) experiments measure the transfer of magnetization from molecular protons to the solvent water protons, an effect that becomes apparent as an MRI signal loss ("saturation"). This allows molecular information to be accessed with the enhanced sensitivity of MRI. In analogy to Magnetic Resonance Spectroscopy (MRS),
Trans-resveratrol (Res) is a well-known natural stilbene frequently found in grapes which have been reported to possess antioxidant, anti-cancer activities and inhibited COX-2 expression. MicroRNAs (miRNAs) are short endogenous non-coding RNAs involved in the regulation of mRNA stability and protein synthesis. In our research, resveratrol isolated from Vitis heyneana Roem. & Schult Vitis heyne
Modern gas turbines always operate at a high level of inlet temperature. The current inlet temperature in the aircraft and heavy duty gas turbines is higher than the melting point of the guide vane material. Consequently, advanced cooling schemes must be developed to ensure the safe operation of gas turbines. In the current study, numerical simulations were conducted to investigate the influence o
The rhinarium, a specialized nose-tip characterized by an area of naked and wet skin around the nostrils, is a typical mammalian structure. The type and amount of innervation suggests a sensory role and morphological diversity implies so far unidentified species-specific functional specializations. Rhinaria also vary in temperature and this may be related to the functions of these sensory organs.
Anodization of aluminum alloys AA 6082 and AA 7075 was investigated in-situ with integrated electrochemical and synchrotron-based X-ray reflectivity (XRR) methods providing complementary information about the anodic processes taking place on the alloys. The stepwise potentiostatic polarization measurements reveal dynamic processes of the anodic oxide formation and dissolution, and the following el
By introducing a non-fullerene small molecule acceptor as a third component to typical polymer donor: fullerene acceptor binary solar cells, we demonstrate that the short circuit current density (Jsc), open circuit voltage (Voc), power conversion efficiency (PCE) and thermal stability can be enhanced simultaneously. The different surface energy of each component causes most of the non-fullerene ac
Purpose: Stigma has been proposed to be one of the most serious obstacles to successful treatment, rehabilitation and inclusion in society of people with severe mental illness. An aspect of stigma which has been increasingly discussed is self-stigma, which refers to the internalization of negative stereotypes among people with severe mental illness. The aim of the present study was to investigate
Background: The glomerular filtration rate (GFR) is the most important measure of kidney function and chronic kidney disease (CKD). This study aims to validate commonly used equations for estimated GFR (eGFR) based on creatinine (cr), cystatin C (cys), β-trace protein (BTP), and β2-microglobulin (B2M) in older adults. Method: We conducted a validation study with 126 participants aged between 72 an
