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Galectins are a family of galactoside-recognizing proteins involved in different galectin-subtype-specific inflammatory and tumor-promoting processes, which motivates the development of inhibitors that are more selective galectin inhibitors than natural ligand fragments. Here, we describe the synthesis and evaluation of 3-C-methyl-gulopyranoside derivatives and their evaluation as galectin inhibit
To provide a consistent database for all important classes of hydrocarbons considered as components of surrogate mixtures, laminar burning velocities of n-decane, p-xylene and methylcyclohexane blended with ethanol were determined using the heat flux method at atmospheric pressure and initial temperatures of 318–400 K. The results obtained at Samara University and Lund University are within overla
In a regulatory context, skin sensitization hazard and risk evaluations of manufactured products and their ingredients (e.g. cosmetics) are mandatory in several regions. Great efforts have been made within the field of 21st Century Toxicology to provide non-animal testing approaches to assess the skin allergy potential of materials (e.g. chemicals, mixtures, nanomaterials, particles). Mechanistic
Upcycling is a process in which used or waste products and materials are repaired, reused, repurposed, refurbished, upgraded and remanufactured in a creative way to add value to the compositional elements. It has been part of human life throughout history, and the past few years have seen its revival, driven by multiple factors including growing concern for the environment and resource scarcity. U
Neglecting extremes and designing buildings for the past or most likely weather conditions is not the best approach for the future. Robust design techniques can, however, be a viable option for tackling future challenges. The concept of robust design was first introduced by Taguchi in the 1940s. The result of the design process is a product that is insensitive to the effect of given sources of var
The intensification of agricultural practices throughout the twentieth century has had large detrimental effects on biodiversity and these are likely to increase as the human population rises, with consequent pressure on land. To offset these negative impacts, agri-environment schemes have been widely implemented, offering financial incentives for land-owners to create or maintain favourable habit
The water use associated with electricity generation and consumption has been the focus of research for decades. This study provides an overview of the water–electricity nexus from the perspectives of electricity production and consumption. In terms of production, the electricity generation and associated water use for various regions are summarized and compared. The spatial mismatch between water
This work presents new constraints on the existence and the binding energy of a possible Λ–Λ bound state, the H-dibaryon, derived from Λ–Λ femtoscopic measurements by the ALICE collaboration. The results are obtained from a new measurement using the femtoscopy technique in (Figure presented.) collisions at s=13 TeV and p–Pb collisions at sNN=5.02 TeV, combined with previously published results fro
We study connectivity in a model of a growing neuronal network in dimensions 2 and 3. Although the axon-to-dendrite proximity is an insufficient condition for establishing a functional synapse, it is still a necessary one. Therefore we study connection probabilities at short distances between the randomly grown axon trees and somas as probabilities of potential connections between the correspondin
The return of Syrian refugees has been a key topic in several forums and policy discussions over the last few years. Yet, the prospects for their return remain grim. The chapter is intended as a stimulus to further examination of an analytical debate, and offers a range of views on the argument that conditions in Syria are still not ripe for return. The chapter addresses Russia’s refugees policies
Cerebral ischemia associated with subarachnoid haemorrhage (SAH) may have severe consequences for neuronal function leading to reversible or permanent neurological deficits. The excitatory amino acid neurotransmitters, such as glutamate, have been shown to be of particular importance for ischemic neuronal damage. In seven patients who underwent early surgery for a ruptured intracranial aneurysm, m
The generation of humanized ectopic ossicles (hOss) in mice has been proposed as an advanced translational and fundamental model to study the human hematopoietic system. The approach relies on the presence of human bone marrow-derived mesenchymal stromal cells (hMSCs) supporting the engraftment of transplanted human hematopoietic stem and progenitor cells (HSPCs). However, the functional distribut
BACKGROUND: Biopsies are routinely obtained in the workup of large colorectal polyps before endoscopic resection. OBJECTIVE: This study aimed to examine how reliable biopsies are in terms of reflecting the true histopathology of large colorectal polyps, in the clinical routine. DESIGN: This is a retrospective study. SETTINGS: Data from patients undergoing polypectomy of large colorectal polyps at
PURPOSE OF REVIEW: Treatments for chronic breathlessness, including opioids and oxygen, have shown efficacy in the controlled laboratory setting, whereas effects have been inconsistent or absent in trials in daily life. This review discusses the lack of standardized exertion as a potential cause of false negative findings for breathlessness in daily life. RECENT FINDINGS: The level of breathlessne
Purpose: To analyse the activity uptakes, effective half-lives and time-integrated activities, of relevance for remnant dosimetry, for patients treated for papillary thyroid cancer (PTC) with a different amount of activity of 131I-NaI. Methods: Fifty patients were included. Of those, 18 patients had low-risk PTC and were treated with 1.11 GBq of 131I-NaI (Group 1), and 32 patients had high-risk PT
