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To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7
A thorough investigation has been performed to assess the microstructural properties, mechanical properties (hardness and elastic modulus), and residual stress development in Ti-6Al-2Sn-4Zr-6Mo (Ti-6246) inertia friction welds in the as-welded and postweld heat-treated conditions. It was evident that the thermomechanical deformation in the weld region occurred above the beta transus, forming dynam
The problem of integrating the Camassa-Holm equation leads to the scattering and inverse scattering problem for the Sturm-Liouville equation -u '' + 1/4 u = lambda wu, where w is a weight function which may change sign but where the left-hand side gives rise to a positive quadratic form so that one is led to a left-definite spectral problem. In this paper the spectral theory and a generalized Four
The electron-ion scattering experiment ELISe is part of the installations envisaged at the new experimental storage ring at the International Facility for Antiproton and Ion Research (FAIR) in Darmstadt, Germany. It offers an unique opportunity to use electrons as probe in investigations of the structure of exotic nuclei. The conceptual design and the scientific challenges of ELISe are presented.
Massive black holes have been discovered in all closely examined galaxies with high velocity dispersion. The case is not as clear for lower-dispersion systems such as low-mass galaxies and globular clusters. Here we suggest that above a critical velocity dispersion similar to 40 km s(-1), massive central black holes will form in relaxed stellar systems at any cosmic epoch. This is because above th
Hip fractures constitute a serious and common health problem from both individual and public health perspectives. Unified data collection and comparison between countries is recognised as an effective tool for care improvements. However, the variation in patients' demography, treatment methods and other local cultural aspects in different countries should be considered. The aim of our study was to
Despite being the world's most abundant natural polymer and one of the most studied, cellulose is still challenging researchers. Cellulose is known to be insoluble in water and in many organic solvents, but can be dissolved in a number of solvents of intermediate properties, like N-methylmorpholine N-oxide and ionic liquids which, apparently, are not related. It can also be dissolved in water at e
This paper describes and discusses learning in repeated acquisitions of innovative firms. Researchers have pointed to how companies may improve performance through conducting repeated acquisitions, while they have not previously focused on repeated acquisitions of innovative firms. Findings of this present study are summarised in five learnings: forming a professional organisation that deals with
A search for Higgs boson pair production [Formula: see text] is performed with 19.5 fb[Formula: see text] of proton-proton collision data at [Formula: see text] TeV, which were recorded by the ATLAS detector at the Large Hadron Collider in 2012. The decay products of each Higgs boson are reconstructed as a high-momentum [Formula: see text] system with either a pair of small-radius jets or a single
Background The effectiveness of cervical cancer screening programs differs widely in different populations. The reasons for these differences are unclear. Routine and comprehensive audits have been proposed as an ethically required component of screening. We performed a nationwide audit of the effectiveness of the Swedish cervical cancer screening program. Methods We identified all invasive cervic
In this paper railway accident investigation reports issued by the national accident investigation boards in three Scandinavian countries during a 2-year period have been systematically studied. Content analysis of attributed causes in these reports reveals a considerable emphasis on physical processes, actor activities and equipment (the microlevel). Much less attention is paid to organisational
Fodor is infamous for his radical conceptual nativism, McDowell likewise well-known for suggesting that concepts extend “all the way out” into the world and arguing against what he calls (per Sellars) The Myth of the Given: the idea that non-conceptual percepts justify conceptual frameworks. One need not go so far as either researcher, however, in allowing merit to their arguments. It seems we are
In this prospective nested case-control study we analyzed the circumferential differences in estimated cortical thickness (Est CTh) of the mid femoral neck as a risk factor for osteoporotic hip fractures in elderly women and men. Segmental QCT analysis of the mid femoral neck was applied to assess cortical thickness in anatomical quadrants. The superior region of the femoral neck was a stronger pr
Centrum för Öresundsstudiers tidskrift "Gränslös. Tidskrift för studier av Öresundsregionens historia, kultur och samhällsliv" ger ut ett specialnummer som fokuserar på ett bortglömt perspektiv i visioner om och analyser av Öresundsregionen – funktionsförmåga. I visionen om Öresundsregionen är det i regel ett friktionsfritt, transnationellt flöde av kroppar som lyfts fram. Visionerna utgår från en
Zero-point vibrational contributions to indirect spin-spin coupling constants for N 2, CO, HF, H 2O, C 2H 2, and CH 4 are calculated via explicitly anharmonic approaches. Thermal averages of indirect spin-spin coupling constants are calculated for the same set of molecules and for C 2X 4, X = H, F, Cl. Potential energy surfaces have been calculated on a grid of points and analytic representations
In January 2005, south-west Sweden was hit by a severe storm that caused large damage to the forests through massive windthrow. The aim of this study was to assess the effect of this windthrow on nitrate concentrations in the soil water below the root zone on 33 forest monitoring plots within the Swedish Throughfall Monitoring Network (SWETHRO). These sites were damaged to different extents by the
