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We demonstrate a solution method that allows both elongation rate and average fibril length of assembling amyloid fibrils to be estimated. The approach involves acquisition of real-time neutron scattering data during the initial stages of seeded growth, using contrast matched buffer to make the seeds effectively invisible to neutrons. As deuterated monomers add on to the seeds, the labelled growin

The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium status biomarkers in relation to overall survival and recurrence following diagnosis of primary invasive breast cancer in a large prospective cohort study. The Sweden Cancerome Analysis Network – Breast Initiative (SCAN-B) is a prospective po

This report summarizes a survey performed in eight countries on the status quo of daylight and electric lighting control systems. Feedback from more than 100 international experts (building / facility managers and planers) was evaluated. The aim of the survey was to identify the perception of the different possibilities of the current lighting control solutions and the expectations about the contr

Vi människor är biologiska varelser och därför sammanvävda med övrigt liv på jorden. Det betyder att vi både för vår överlevnad och för vår vällevnad är helt beroende, inte bara av att det finns en rikedom av liv på planeten, utan också av ett otal ekologiska funktioner som genereras av levande organismer, av enskilda arter eller av flera arter i samspel. Det handlar om direkt livsuppehållande fun

Vårt traditionella jordbrukslandskap är centralt för att bevara biologisk mångfald, men det moderna jordbruket har medfört förändringar som bidragit till en utarmning av mångfalden. Detta hotar de ekosystemtjänster som naturbetesmarker och deras mångfald kan bidra med. Sverige har i tusentals år haft betesdjur som en integrerad del av matproduktionen, vilket har format landskap med en variation av

Pollinatörer är en fråga i tiden. I slutet av 1990-talet introducerade Gretchen Daily och Robert Costanza begreppet ekosystemtjänster för att beskriva människans beroende av naturliga processer och produkter som skapas av våra ekosystem. Begreppet har sedan dess fått ett enormt genomslag inom vetenskap och policy och var centralt för IPBES globala utvärdering av biologisk mångfald och ekosystemtjä

The epoch of the Anthropocene, a period during which human activity has been the dominant influence on climate and the environment, has witnessed a decline in oxygen concentrations and an expansion of oxygen-depleted environments in both coastal and open ocean systems since the middle of the 20th century. This paper provides a review of system-specific drivers of low oxygen in a range of case stud

The town of Blera is situated in the southern parts of Etruria and has a history spanning more than 2,500 years. Its location between the two important Etruscan cities of Tarquinii and Caere has meant that Blera, for the entire Etruscan period (c. 750–50 BC), alternatively has found itself in either city’s sphere of interest. When Rome begins her expansion into Etruria, following the fall of the sThe town of Blera is situated in the southern parts of Etruria and has a history spanning more than 2,500 years. Its location between the two important Etruscan cities of Tarquinii and Caere has meant that Blera, for the entire Etruscan period (c. 750–50 BC), alternatively has found itself in either city’s sphere of interest. When Rome begins her expansion into Etruria, following the fall of the s

Background: There is conflicting observational data on the survival benefit cardiac implantable electronic devices (CIED) in patients with LVADs. Methods: Patients in whom an LVAD was implanted between January 2008 and April 2017 in the multinational Trans-Atlantic Registry on VAD and Transplant (TRAViATA) registry were separated into four groups based on the presence of CIED prior to LVAD implant

Background and purpose: Fibroblast growth factor 23 (FGF23) is an osteogenic hormone associated with chronic kidney disease and is an emerging risk factor for several cardiovascular diseases. The association of FGF23 with stroke is unclear. The aim of this study was to investigate the association of FGF23 with incident intracerebral hemorrhage (ICH). Methods: This was a nested case–control study o

Background: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. Methods: We applied Mendelian randomisation (MR) to evaluate a potential causal effect of cigarette smoking on breast cancer risk. Both individual-level data as well as summary statistics

Purpose: The application of automated image analyses could improve and facilitate standardization and consistency of quantification in [18F]DCFPyL (PSMA) PET/CT scans. In the current study, we analytically validated aPROMISE, a software as a medical device that segments organs in low-dose CT images with deep learning, and subsequently detects and quantifies potential pathological lesions in PSMA P

Sentimentalists believe that values are crucially dependent on emotions. Epistemic sentimentalists subscribe to what I call the final-court-of-appeal view: emotional experience is ultimately necessary and can be sufficient for the justification of evaluative beliefs. This paper rejects this view defending a moderate version of rationalism that steers clear of the excesses of both “Stoic” rationali

Optical wireless networks realized by means of gigabit optical wireless communication (OWC) systems are becoming, in a variety of applications, an important alternative, or a complementary solution, to their fiber-based counterparts. However, performance of the OWC systems can be considerably degraded in periods of unfavorable weather conditions, such as heavy fog, which temporarily reduce the eff

Objectives: To investigate absolute and relative risk of serious infections in adult/elderly inflammatory bowel disease (IBD) diagnosed 2002–2017. Methods: Nationwide, register-based cohort study of Swedish patients with IBD compared with general population matched reference individuals with regard to time to first serious infection, equal to hospital admission. Multivariable Cox regression estima

Using a selection of molecular biomarkers, we evaluated responses in freshwater mussels (Anodonta anatina) exposed to effluent from an industrial wastewater treatment facility. The aims of this work were to (1) assess biomarkers of general toxicity under sublethal exposure to an anthropogenic mixture of chemicals, represented by an arbitrary effluent, and (2) evaluate the potential of A. anatina a

While the energy transition of the EU housing stock is now being intensified with the launch of the Renovation Wave, economic inequalities are increasing in many OECD countries, which has effects on housing-related inequalities and the demand of affordable housing. The Renovation Wave is thus an opportunity to improve housing quality for low-income households, but also entails risks for increased While the energy transition of the EU housing stock is now being intensified with the launch of the Renovation Wave, economic inequalities are increasing in many OECD countries, which has effects on housing-related inequalities and the demand of affordable housing. The Renovation Wave is thus an opportunity to improve housing quality for low-income households, but also entails risks for increased