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Ionizing radiation impairs male fertility, but the ultrastructural lesions linking radiation to sperm dysfunction remain unclear. The sperm annulus, a ring structure essential for flagellar in-tegrity, is a potential but unresolved target. Here, we integrate synchrotron X-ray ptychography, cryogenic soft X-ray tomog-raphy, electron microscopy, and confocal imaging for cross-scale visualization of
Data centers serve as crucial infrastructure for the development of the digital economy, and maintaining their thermal environment is essential for ensuring that computing equipment can execute workload properly. Thermal environment management and workload scheduling are mutually influential; however, current research often treats them separately, overlooking their bidirectional coupling relations
Objective: To describe the clinical and ultrasound characteristics of ovarian mature cystic teratoma containing malignancy. Methods: This was an international, retrospective, observational study. We invited 19 (oncological or non-oncological) gynecological centers to provide clinical and ultrasound information on cases of histologically confirmed ovarian mature cystic teratoma containing malignanc
Background: Hippocampal sclerosis of aging (HS-A), a common cause of dementia, can currently only be diagnosed at autopsy. We aimed to identify and evaluate MRI metrics to distinguish HS-A from Alzheimer’s Disease neuropathologic change (ADNC) and cases with limited/no pathology. Methods: HS-A (N = 5), ADNC (N = 10), and limited/no pathology (N = 12) cases were compared on postmortem MRI signature
Introduction: Laparoscopic-assisted renal cryoablation (LRC) is a treatment option for small renal masses (SRMs), offering a nephron-sparing alternative to partial nephrectomy. This study evaluated long-term oncologic outcomes and perioperative complications after LRC in a single-center cohort. Methods: We conducted a retrospective single-center review of 52 patients who underwent LRC for SRMs ≤4
Context: Levothyroxine (LT4) is the primary treatment of hypothyroidism. Despite adequate LT4 substitution some patients experience symptoms and the use of adjunct liothyronine (LT3) has increased. Several trials show no clear advantage of LT4 + LT3, and observational studies report conflicting results. Objective: We aimed to assess the relationship between initiation of LT3 treatment and psychiat
With global warming, precipitation variability is increasing, affecting water availability and consequently ecosystem functioning and carbon uptake. Semi-arid ecosystems are very sensitive to changes in water availability since both gross primary productivity (GPP) and ecosystem respiration (Reco) are strongly linked to it, contributing most to the interannual variability and trend of the global l
The stellar-mass–halo-mass (SMHM) relation is central to our understanding of galaxy formation and the nature of dark matter. However, its normalization, slope, and scatter are highly uncertain at dwarf galaxy scales. In this paper, we present DarkLight, a new semi-empirical dwarf galaxy formation model designed to robustly predict the SMHM relation for the smallest galaxies. DarkLight harnesses a
Introduction: Timely diagnosis and treatment are essential for improving outcomes and quality of life in patients with transthyretin (ATTR) amyloidosis. Early multisystem manifestations are often unrecognized, leading to diagnostic delays and misdiagnosis. Large-scale, multicountry, observational studies are needed to better characterize the real-world trajectory of these patients. Methods: OverTT
Research on the underwater archaeological site of Bulverket has been ongoing forover 100 years. Bulverket was a large square wooden platform, built in the middle ofa large shallow lake on northern Gotland in the early 1130s. On top of the platformwere numerous houses constructed with a wide variety of contemporary buildingtechniques, including wickerwork, stave construction, corner-post constructi
Essay on Lund university as a cultural institution
MicroRNAs (miRNAs) have emerged as central regulators of pancreatic islet biology, influencing β-cell development, proliferation, and function. In type 2 diabetes (T2D), both adaptive and maladaptive miRNA responses shape β-cell compensation and progressive secretory dysfunction. Here, we review current insights into the regulation of insulin secretion, with a focus on exocytosis and the autocrine
Acinetobacter guillouiae I-MWF was isolated by incubating amorphous polyethylene terephthalate (PET) film in sludge samples. The strain partially depolymerised PET powder with 11.3% crystallinity, as confirmed by FT-IR, HPLC-UV, and LC-MS analyses. Extracellular enzymes released terephthalic acid (TPA), mono(2-hydroxyethyl) terephthalate (MHET), and bis(2-hydroxyethyl) terephthalate (BHET). Genomi
Understanding and modeling human mobility is central to challenges in transport planning, sustainable urban design, and public health. Despite decades of effort, simulating individual mobility remains challenging because of its complex, context-dependent, and exploratory nature. Here, building on the activity-based view of daily mobility, we propose MobilityGen, a diffusion-based generative framew
Adrenoleukodystrophy (ALD) is an X-linked recessive disease caused by defects in the ABCD1 gene, leading to the accumulation of very long-chain fatty acids in the nervous system, adrenalglands, blood and other tissues. Male ALD patients may present with either the severe neurologicalphenotype of cerebral ALD, characterized by inflammatory demyelination in the white matter and rapid neurological de
Cancer stem cells (CSCs) are tumor cell subsets with self-renewal, multilineage differentiation, and tumor-initiating capacity that sustain cancer initiation, progression, metastasis, and relapse. Targeting CSCs therefore represents a promising route to improve the durability of cancer treatment. However, translation of this approach into routine care has been slow because of the biological comple
X-ray-scattering tensor tomography requires dark-field measurements in the projection domain that are both unbiased and rotation equivariant. We show that, in the context of circular-grating-based tensor tomography, the commonly used cell-based chord retrieval (CCR) cannot satisfy either requirement. From the two-dimensional convolution model of circular gratings, we derive a closed-form expressio
