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Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known. Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airwa
Background and purpose — Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). Patients and methods — This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty
An emissions barrier was used in premises with indoor air complaints due to emissions from the buildings in question. The emissions comprised chlorophenols/chloroanisoles and polycyclic aromatic hydrocarbons (PAH) from treated wood, volatile organic compounds (VOC) from PVC flooring and/or the glue used to paste the flooring onto a concrete slab, and radon from radium-containing aerated concrete.
Learning outcomes: This case study covers different concepts related to leadership. It should help students analyze business situations from a leader’s perspective. By the end of this case study, students would be able to understand the role and the characteristics of leadership during a crisis using the 11 dimensions of character framework, map leadership personalities using the HEXACO model to u
Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at s = 13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (p T) of 0.2 GeV/c and up to p T = 35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p-Pb collisions, the production cross section and the nuclear modificati
A new, more precise measurement of the Λ hyperon lifetime is performed using a large data sample of Pb-Pb collisions at sNN=5.02 TeV with ALICE. The Λ and Λ¯ hyperons are reconstructed at midrapidity using their two-body weak decay channel Λ→p+π- and Λ¯→p¯+π+. The measured value of the Λ lifetime is τΛ=[261.07±0.37(stat.)±0.72(syst.)] ps. The relative difference between the lifetime of Λ and Λ¯, w
Average nucleotide identity analysis, based on whole genome sequences of 115 strains previously identified as Aerococcus urinae, an emerging uropathogen, discriminates at least six unique genomic taxa. The whole genome analysis affords clearer species boundaries over 16S rRNA gene sequencing and traditional phenotypic approaches for the identification and phylogenetic organization of Aerococcus sp
The transverse-momentum (pT) spectra and coalescence parameters B2 of (anti)deuterons are measured in p-p collisions at s=13 TeV for the first time in and out of jets. In this measurement, the direction of the leading particle with the highest pT in the event (pTlead>5 GeV/c) is used as an approximation for the jet axis. The event is consequently divided into three azimuthal regions, and the jet s
The azimuthal (Δ φ) correlation distributions between heavy-flavor decay electrons and associated charged particles are measured in pp and p–Pb collisions at sNN=5.02 TeV. Results are reported for electrons with transverse momentum 4 < pT< 16 GeV / c and pseudorapidity | η| < 0.6 . The associated charged particles are selected with transverse momentum 1 < pT< 7 GeV / c , and relative pseudorapidit
Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of Cartpt knockdown (KD) INS-1 832/13 cells and identified GPR162 as the most Cartpt-regulated receptor.
Introduction: High convection volumes in hemodiafiltration (HDF) result in improved survival; however, it remains unclear whether it is achievable in all patients. Methods: CONVINCE, a randomized controlled trial, randomized patients with end-stage kidney disease 1:1 to high-dose HDF versus high-flux hemodialysis (HD) continuation. We evaluated the proportion of patients achieving high-dose HDF ta
A search for vector-like leptons in multilepton (two, three, or four-or-more electrons plus muons) final states with zero or more hadronic τ-lepton decays is presented. The search is performed using a dataset corresponding to an integrated luminosity of 139 fb−1 of proton-proton collisions at a centre-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. To maximize the separation of
Instrumental variable methods are often used for parameter estimation in the presence of confounding. They can also be applied in stochastic processes. Instrumental variable analysis exploits moment equations to obtain estimators for causal parameters. We show that in stochastic processes one can find such moment equations using an integrated covariance matrix. This provides new instrumental varia
The identification of b-jets, referred to as b-tagging, is an important part of many physics analyses in the ATLAS experiment at the Large Hadron Collider and an accurate calibration of its performance is essential for high-quality physics results. This publication describes the calibration of the light-flavour jet mistagging efficiency in a data sample of proton–proton collision events at s=13 Te
Objective: To investigate the association between female body mass index (BMI) and live birth rates and maternal and perinatal outcomes after in-vitro fertilization (IVF). Methods: We performed a national, population-based cohort study including women undergoing IVF between 2002 and 2020. The cohort included 126,620 fresh cycles and subsequent frozen embryo transfers between 2007 and 2019 (subpopu
The performance of superconducting devices is often degraded by the uncontrolled appearance and disappearance of quasiparticles, a process known as poisoning. We demonstrate the electrostatic control of quasiparticle poisoning in the form of single-charge tunneling across a fixed barrier onto a Coulomb island in an InAs/Al hybrid nanowire. High-bandwidth charge sensing was used to monitor the char
A search for resonances in events with at least one isolated lepton (e or μ) and two jets is performed using 139 fb −1 of s = 13 TeV proton–proton collision data recorded by the ATLAS detector at the LHC. Deviations from a smoothly falling background hypothesis are tested in three- and four-body invariant mass distributions constructed from leptons and jets, including jets identified as originatin
Our aim was to clarify the anatomy and function of the retinacular ligaments. Forty-eight fingers were dissected and the thickness of the oblique retinacular ligament (ORL) was graded. In four fingers, the motion in the proximal interphalangeal (PIP) and distal interphalangeal (DIP) joints was subjected to an in-depth analysis before and after sectioning of either the lateral bands (LB) or the ORL
A search for a new heavy scalar or pseudo-scalar Higgs boson (H/A) produced in association with a pair of top quarks, with the Higgs boson decaying into a pair of top quarks (H/A → tt¯) is reported. The search targets a final state with exactly two leptons with same-sign electric charges or at least three leptons. The analysed dataset corresponds to an integrated luminosity of 139 fb −1 of proton–
