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A functionally normal TP53 is essential to protect organisms from developing cancer. Somatic mutations in the gene represent one of the highest recurring perturbations in human tumours, including colorectal cancer (CRC). However, the variegated phenotype of wide spectrum of somatic mutations in TP53 and the complexity of the disease prevent a straight interpretation of the mutational analysis in t
Airborne pollen has been associated with allergic symptoms in sensitized individuals, whereas atmospheric pollution indisputably aggravates the impact on the overall quality of life. Therefore, it is of major importance to correlate, forecast and disseminate information concerning high concentration levels of allergic pollen types and air pollutants to the public, in order to safeguard the quality
Popular Abstract in Danish Fysioterapi er en social og etisk praksis som udfolder sig under specifikke historiske, politiske, socialkulturelle og økonomiske forhold. Dansk fysioterapi i en privat kontekst er praktiseret, administreret og håndteret indenfor en neoliberal ideologi, der genererer udfordringer for både fysioterapeuter og borgere: Det forventes implicit at begge parter understøtter denPhysiotherapy is a social and ethical practice which unfolds under specific historical, political, socio-cultural and economic circumstances. Danish physiotherapy in a private context is practiced, administered and managed within a neoliberal ideology which generates challenges for both physiotherapists and their patients. This thesis aims to explore how physiotherapy in a Danish private context s
It is over three decades since a large terrestrial carbon sink (S-T) was first reported. The magnitude of the net sink is now relatively well known, and its importance for dampening atmospheric CO2 accumulation, and hence climate change, widely recognised. But the contributions of underlying processes are not well defined, particularly the role of emissions from land-use change (E-LUC) versus the
Objective. The association between smoking and idiopathic inflammatory bowel disease is well known; smoking seems to have a diverse effect. Crohn's disease is associated with smoking, while ulcerative colitis is associated with non-smoking. Data on smoking in microscopic colitis of the collagenous type (CC) are lacking. The aim of this investigation was to study smoking habits in CC and to observe
We have investigated multiphoton multiple ionization of argon and xenon atoms at 5 keV using a new x-ray free electron laser (XFEL) facility, the SPring-8 Angstrom Compact free electron LAser (SACLA) in Japan. The experimental results are compared with the new theoretical results presented here. The absolute fluence of the XFEL pulse has been determined with the help of the calculations utilizing
I klinisk praxis görs palpation per rektum rutinmässigt på vuxna patienter vid akut buk. Vi utvärderade evidensen för detta genom en systematisk litteratursökning och identifierade 16 relevanta originalstudier. Dessa visade att det saknas evidens för diagnostisk nytta av rektalpalpation vid akut buk, inklusive misstänkt appendicit. Rutinmässig rektalpalpation bör inte göras vid akut buk hos vuxnaA digital rectal examination (DRE) is standard practice in cases of acute abdomen in adult patients. We analyzed the evidence for this by a systematic literature search, and identified 16 relevant original studies. These studies showed that there is no evidence for a diagnostic value of DRE in adult patients with acute abdomen. We should stop doing routine DRE in adult cases of acute abdomen.
A large part of new pharmaceutical substances are characterized by a poor solubility and high hydrophobicity, which might lead to a difference in drug adsorption between fasted and fed patients. We have previously evaluated the release of hydrophobic drugs from tablets based on Pemulen TR2 and showed that the release can be manipulated by adding surfactants. Here we further evaluate the possibilit
Abstract in UndeterminedThe aim of this study was to evaluate the extent to which water use efficiency (WUE) at leaf scale can be used to assess WUE at canopy scale, leaf WUE being assumed to be a constant function of vapor pressure deficit and to thus not be dependent upon other environmental factors or varying leaf properties. Leaf WUE and its variability and dependencies were assessed using lea
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Free space optics is an interesting alternative for telemetry with medical implants, due to the high data bandwidths available at optical frequencies. Especially implanted brain-computer interfaces gives rise to large data sets that needs to be transmitted transcutaneous. In this paper we show that it is possible to establish such a link at near-IR wavelengths using a modulated reflector in the im
Abstract Levels of natural radioactivity such as 222Rn (radon) and its long-lived daughters 210Pb and 210Po were measured. The radon gas was trapped on cooled charcoal filters and the long-lived daughter products sampled on fibre filters on a daily basis. In addition, short-lived progenies were followed continuously on the filters in order to achieve a time resolution of about one hour. The ave
The initial growth of MnBi on MnAs-terminated (GaMn)As is studied by means of synchrotron-based photoelectron spectroscopy. From analysis of surface core-level shifts we conclude that a continued epitaxial MnBi layer is formed, in which the MnAs/MnBi interface occurs between As and Bi atomic planes. The well-defined 1×2 surface reconstruction of the MnAs surface is preserved for up to 2 ML of MnBi
Surgical staff is considered to have several ergonomic risk factors, but their physical workload and musculoskeletal health have seldom been evaluated. Clinical examinations of neck and upper extremities were performed in 99 theatre nurses and 93 assisting nurses, all females. Their physical workload was assessed by questionnaire, and by technical measurements of postures, movements and muscular l
Almost every day a school fire occurs in Sweden. In most cases arson is the cause of the fire. The losses for these arson fires are considerable. In this report a number of cases studies have been conducted on school fires in Sweden. The project envisages obtaining more knowledge on the technical factors that influence the spread of fires with arson in schools. Solutions to mitigate the fire sp
Political institutions are keen to use the best available scientific knowledge in decision-making. For environmental policy, relevant scientific evidence can be complex and extensive, so expert judgment is frequently relied upon, without clear links to the evidence itself. We propose a new transparent process for incorporating research evidence into policy decisions, involving independent synopsis
To better understand prostate function and disease, it is important to define and explore the molecular constituents that signify the prostate gland. The aim of this study was to define the prostate specific transcriptome and proteome, in comparison to 26 other human tissues. Deep sequencing of mRNA (RNA-seq) and immunohistochemistry-based protein profiling were combined to identify prostate speci
A search for neutral Higgs bosons decaying to pairs of tau leptons with the ATLAS detector at the LHC is presented. The analysis is based on proton-proton collisions at a center-of-mass energy of 7 TeV, recorded in 2010 and corresponding to an integrated luminosity of 36 pb(-1). After signal selection, 276 events are observed in this data sample. The observed number of events is consistent with th
