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Clear Cell Renal Cell Carcinoma (CCRCC) is a lethal cancer with bad prognosis due to development of chemoresistance and recurrence of more aggressive tumors. Investigation of Gas6-mediated Axl signaling in CCRCC and endothelial cells reveals a Sunitinib resistant Gas6-Axl signaling that is sustained and enhanced and specifically triggers downstream AKT and PRAS40 activation in an intensified manne
Part I of the study presents the importance and the analytical and numerical methods to perform a thermal- mechanical stress simulation with evenly distributed temperature for single wires. Part II of the study presents a method with thermal and mechanical conjugated simulations with unevenly distributed temperature for multiple wires and the results are compared to the structural simulation with
The new forms of communication facilitated by the IT revolution have provided followers of various interpretations of Islam to participate in the newly opened public spheres. More and more Muslims find it possible to choose among these competing authorities and to select a suitable fatwa, to solve problems of everyday life and to smooth adjustments to living in the new environments. IT revolution
This study examines the factors that have shaped the long-term evolution of the ICT industry in Sweden, 1950-2013. Exploiting a new historical micro-database on actual innovation output, the driving forces and technological interdependencies in the third industrial revolution are chronicled. The results of this study support some stylized facts about innovational interdependencies in general-purpo
To what extent have public policies contributed to the innovation performance of Finland and Sweden in the period 1970-2013? This paper aims to assess the share of innovations stimulated by the public sector, specifically because of receiving public funding or being the result of research collaboration with public institutions. We combine survey and LBIO results on these variables, to overcome rep
Integration of non-dispatchable renewable energy sources such as wind and solar into the grid is challenging due to the stochastic nature of energy sources. Hence, electrical hubs (EH) and virtual power plants that combine non-dispatchable energy sources, energy storage and dispatchable energy sources such as internal combustion generators and micro gas turbines are getting popular. However, desig
BACKGROUND: Enzymatic hydrolysis of lignocellulose is associated with mixing issues, which are likely to affect process performance. The aim of this study was to investigate how viscosity and sugar inhibition influence the mixing-dependence in hydrolysis of steam-pretreated spruce. RESULTS: The effect of agitation on low-viscosity, low-solid hydrolysis (5% water insoluble solid (WIS)) was marginal
A novel electron deficient 4,6-bis(trifluoromethyl)-1,3-phenylene diphosphinite ligand 4 was developed and synthesized. Reaction of Ir precursors with ligand 4 gave chloro(hydride) pincer complex 5, which demonstrated a higher TON in alkane dehydrogenation reactions compared to similar phosphinite based pre-catalysts. The formation of cyclooctene (COE) and tert-butylethylene adducts of the 14e cat
The focus of this paper is on investigating the influence of skewing on the torque production of an Interior Permanent Magnet Synchronous Machine (IPMSM). The machine is designed as a traction machine according to the requirements of a parallel hybrid electric commercial heavy vehicle. In order to meet the requirements, the machine is designed with a speed higher than that of the conventional powe
The topic of this paper is the role of benchmarking in Chinese e-government. Through content analysis of documentary material, this paper addresses the following questions: Which benchmarking schemes have been applied to e-government in China? What are the intentions behind the different benchmarking schemes? and Whose interests are served? Whereas previous research finds that benchmarking address
Combining straightforward molecular imprinting with orthogonal click chemistry and accessible fluorescent dyes, a modular approach has been developed to assemble turn-on optical sensors based on fluorescence resonance energy transfer in molecularly imprinted nanoparticles.
Purpose - The purpose of this paper is to investigate the numerical fluid-structure interaction (FSI) framework for the simulations of mechanical behavior of new vortex generators (VGs) in smooth wavy fin-and-elliptical tube (SWFET) heat exchanger using the ANSYS MFX Multi-field® solver. Design/methodology/approach - A three-dimensional FSI approach is proposed in this paper to provide better unde
This concluding chapter gives an overview of social inclusiveness at universities in the 11 countries covered in this book. Which are the most important obstacles for young people to do higher education studies, why do such obstacles remain, and what, if anything, is being done about it? One interesting aspect of the country studies is the difference when it comes to the role of private universiti
We extend the Tasche (2007) model on the asset correlation bias caused by a currency mismatch between assets and liabilities to the more realistic situation where just some assets and liabilities are denominated in a foreign currency. To test the significance of the remaining bias we rely on a unique database constructed by the Inter-American Development Bank (IADB) containing time-series of the a
