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The National Institute on Aging and the Alzheimer's Association convened three separate work groups in 2011 and single work groups in 2012 and 2018 to create recommendations for the diagnosis and characterization of Alzheimer's disease (AD). The present document updates the 2018 research framework in response to several recent developments. Defining diseases biologically, rather than based on synd
Large eddy simulations of pilot fuel ignited, lean premixed, natural gas engines are performed to study the pilot-ignition process and its subsequent interaction with the premixed charge. The injection pressure (Pinj) and injection duration (Δinj) are varied (i.e. 800 bar/760μs, 800 bar/500μs, and 400bar/760μs) to study the impact of the injection process on the subsequent combustion evolution. Op
2D van der Waals (vdW) magnets are gaining attention in fundamental physics and advanced spintronics, due to their unique dimension-dependent magnetism and potential for ultra-compact integration. However, achieving intrinsic ferromagnetism with high Curie temperature (TC) remains a technical challenge, including preparation and stability issues. Herein, an applicable electrochemical intercalation
BACKGROUND: The effect of myocardial infarction (MI) on life expectancy is difficult to study because the prevalence of MI hinders direct comparison with the life expectancy of the general population. We sought to assess this in relation to age, sex, and left ventricular ejection fraction (LVEF) by comparing individuals with MI with matched comparators without previous MI. METHODS: We included pat
We study optimal seeding problems for binary super-modular network games. The system planner's objective is to design a minimal cost seeding guaranteeing that at least a predefined fraction of the players adopt a certain action in every Nash equilibrium. Since the problem is known to be NP-hard and its exact solution would require full knowledge of the network structure, we focus on approximate so
Immune thrombocytopenia (ITP) is an autoimmune bleeding disease caused by immune-mediated platelet destruction and decreased platelet production. ITP is characterized by an isolated thrombocytopenia (<100 × 109/L) and increased risk of bleeding. The disease has a complex pathophysiology wherein immune tolerance breakdown leads to platelet and megakaryocyte destruction. Therapeutics such as cortico
This article examines the entangled worlds of anti-colonialism and anarchism in Weimar era Berlin. Looking particularly at Agnes Smedley and her partner in Berlin, Virendranath Chattopadhyaya, as well as M.P.T.Acharya and others, the article explores the ways in which these figures approached the question of anarchism in relation to Indian anti-colonialism. While recent scholarship has focused on
Despite diagnostic algorithms, identification of venous thromboembolism (VTE) in emergency departments (ED) remains a challenge. We evaluated symptoms, background, and laboratory data in 27,647 ED patients presenting with pain, swelling, or other symptoms from the extremities, and identified predictors of VTE diagnosis within one year. Predictors of a clinical decision to perform phlebography, ult
The first keyword, Welfare State, sets out to problematise the term itself. The welfare state is a national construct, a ‘national social state’ as Etienne Balibar calls it. Thus, transnational or global migration is often construed as a disruptive force, potentially destabilising the welfare state and the nation. This keyword entry critically examines common conceptions of what the welfare state
Banishment concludes the keyword discussion by arguing that we can understand the exclusionary practices of welfare states as a politics of destitution, which ultimately leads to the banishment of unwanted individuals. It argues that banishment can be helpful as a conceptual lens through which to understand the purposeful strategies that render individuals deportable, whether citizens or non-citiz
Skogen och skogsbruket har idag en stark närvaro i klimatdebatten. Det finns bred enighet om att skogen har stor betydelse för klimatfrågan, men olika syn på vilka dessa klimatnyttor kan vara. Antalet studier inom området är omfattande och relevant styrning utvecklas över tid. Kunskapsläget är dock svåröverblickbart, vilket beror på att olika metoder, antaganden och tidshorisonter använts i olika
In this study, a solar dryer incorporating a flat plate heat exchanger to recover heat from exhaust air was investigated to explore the usability of different types of collectors in the system. Their usability was further evaluated through economic and environmental analyses. Moreover, the thermodynamic performance of the solar dryers was evaluated under two weather conditions in Nepal. Apple dryi
Numerous studies have demonstrated the significant impact of the resolution of solar irradiation data on the outcomes of hourly production models. Accurate integration of photovoltaic (PV) systems sometimes demands a high-resolution global horizontal irradiance (GHI) time series to capture the rapid fluctuations in PV power output induced by swift irradiance changes. Most of the available database
The issuance of building permits is a crucial process for urban development in accordance with the law and sustainability goals. Building permits in Europe involve a complex tapestry of processes, regulations, and methodologies. Despite its critical role in shaping the urban landscape, detailed investigations of building permitting process have been scarce. This gap in knowledge not only hinders t
Poly(butylene adipate-co-terephthalate) (PBAT) is an important commercial biodegradable flexible copolyester, which is dependent on the fossil-based terephthalates for production. In the present work, two series of PBAT-mimicking copolyesters are synthesized using lignin-sourced aromatic monomers, i.e., methyl 4-(2-hydroxyethoxy) vanillate and methyl 4-(2-hydroxyethoxy) benzoate, aliphatic dimethy
Abstract Thiosilvatins are a family of biologically active sulfenylated diketopiperazine natural products. The first members were reported over 40?years ago, but total synthesis of a thiosilvatin has remained elusive. Here, we describe the first, collective, synthesis of the parent epidithiodiketopiperazine (?)-dithiosilvatin and ten related thiosilvatins. Several of the targets are structurally rThiosilvatins are a family of biologically active sulfenylated diketopiperazine natural products. The first members were reported over 40 years ago, but total synthesis of a thiosilvatin has remained elusive. Here, we describe the first, collective, synthesis of the parent epidithiodiketopiperazine (−)-dithiosilvatin and ten related thiosilvatins. Several of the targets are structurally revis
