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Background: A significant subset of prostate cancer (PC) patients with a castration-resistant form of the disease (CRPC) show primary resistance to androgen receptor (AR)-targeting drugs developed against CRPC. As one explanation could be the expression of constitutively active androgen receptor splice variants (AR-Vs), our current objectives were to study AR-Vs and other AR aberrations to better
Liksom i tidigare essäsamlingar visar Anders Cullhed i "Tidens guld" på förbindelser mellan antik, tidigmodern, modern och modernistisk litteratur.
Macronutrient intake, the proportion of calories consumed from carbohydrate, fat, and protein, is an important risk factor for metabolic diseases with significant familial aggregation. Previous studies have identified two genetic loci for macronutrient intake, but incomplete coverage of genetic variation and modest sample sizes have hindered the discovery of additional loci. Here, we expanded the
Copy-paste-modify is a form of software reuse in which developers explicitly duplicate source code. This duplicated source code, amounting to a code clone, is adapted for a new purpose. Copy-paste-modify is popular among software developers, however, empirical evidence shows that it complicates software maintenance and increases the frequency of bugs. To allow developers to use copy-paste-modify w
This paper presents a new measure polyarchy for a global sample of 182 countries from 1900 to 2017 based on the Varieties of Democracy (V-Dem) data, deriving from an expert survey of more than 3000 country experts from around the world, with on average 5 experts rating each indicator. By measuring the five components of Elected Officials, Clean Elections, Associational Autonomy, Inclusive Citizens
Neutrophil extracellular traps (NETs) consist of a decondensed DNA scaffold decorated with neutrophil-derived proteins. The proteome of NETs, or "NETome," has been largely elucidated in vitro. However, components such as plasma and extracellular matrix proteins may affect the NETome under physiological conditions. Here, using a reductionistic approach, we explored the effects of two proteases acti
Lodging is the process where crop plants fall over and lie on the ground due to strong winds and heavy precipitation. This problem reduces yield and increases the risk of fungal infections and pre-harvest germination. In order to avoid lodging, plant breeders utilize short-culm mutants, which often have a robust culm that can support the weight of a heavy spike. In barley (Hordeum vulgare L.), tho
By studying servitization processes and service competencies in the wind-to-energy industry in European regions, this paper provides a framework for territorial servitization. The framework resonates with the concepts of knowledge-intensive business services (KIBS) and industry life cycles, and its elements can be embedded into concepts of regional development (e.g., lead-market models, sustainabi
Domain decomposition based time integrators allow the usage of parallel and distributed hardware, making them well-suited for the temporal discretization of parabolic systems. In this study, a rigours convergence analysis is given for such integrators without assuming any restrictive regularity on the solutions or the domains. The analysis is conducted by first deriving a new variational framework
When leaving the nest for the first time, bees and wasps perform elaborate learning flights, during which the location of the nest is memorised. These flights are characterised by a succession of arcs or loops of increasing radius centred around the nest, with an incremental increase in ground speed, which requires precise control of the flight manoeuvres by the insect. Here, we investigated the r
This article argues that the (re-)constitution of diplomacy is intimately linked to gender and the practices of exclusion and inclusion of women and men over time. While the big debates in both academia and among practitioners concern the change and continuity of diplomacy in the last hundred years, gender has received scant, if any, attention. The overarching aim of this article is therefore to a
The economy-wide dynamic cost-benefit study of the Swedish industrial subsidy program 1976 through 1984 (Carlsson et al. Res Policy 10(43):336–354 1981; Carlsson J Ind Econ 32(1):9–14, 1983a, b) is revisited in light of later economic development. Since the Swedish Micro to Macro model (Eliasson Am Econ Rev 67(1):277–281 1977a, 2017a) was used for quantification, this article is both (1) a study o
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