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Pediatric cancers exhibit complex evolutionary dynamics driven by genetic instability, clonal selection, epigenetic reprogramming, and microenvironmental interactions. Tumor evolution is typically characterized by branching phylogenies, where subclones with unique genetic profiles emerge at different locations and time points. Partly as a result of this diversity, advanced cancers often develop re

Background: Biliary acute pancreatitis (AP) during pregnancy is a challenging situation, and current guidelines for AP, pregnancy care, and surgery do not specifically address its management. This study investigated the safety and effectiveness of cholecystectomy and endoscopic retrograde cholangiopancreatography (ERCP) during pregnancy in AP. Methods: This international retrospective multicenter

Introduction: Our objective was to evaluate the association of early-pregnancy body mass index (BMI) in women with gestational diabetes mellitus (GDM) with maternal, delivery, and child outcomes, and compare with pregnancies without diabetes in southeastern Sweden, including after a surge of non-European immigration. Material and Methods: A retrospective population-based observational study of all

Northern mires are significant natural sources of atmospheric methane (CH4), yet estimating CH4 emissions remains challenging due to their complex spatio-temporal dynamics. While eddy covariance (EC) measurements provide valuable insights into ecosystem-scale CH4 fluxes (FCH4) over mire areas typically < 0.05 km², the predictability of FCH4 at the mesoscale (∼0.5 – 20 km²) of a mire complex based

In this paper we argue that too little attention has been directed to age-related psychological and relational conditions for creating viable forms of democracy in the workplace. Working life is complex and there are many factors throughout the working life journey that affect individuals and how they feel, can, want, have the energy, are heard, motivated and cope with their working life. Currentl

BACKGROUND: This study sought to characterize a cohort of talar neck and body fractures, focusing on fracture characteristics, associated injuries, treatment and outcome.METHODS: We reviewed adult patients registered in the Swedish Fracture Register 2011-2021 with talar neck and body fractures. A minimum 2-year follow-up was conducted for treatment outcomes.RESULTS: We included 313 patients (318 f

Background: Accurate volumetry and imaging characterization of chronic subdural hematoma (cSDH) are essential for prognostication and treatment planning, but manual assessment is time-consuming and therefore underutilized. Methods: We retrospectively analyzed preoperative non-contrast CT (NCCT) scans of 257 patients undergoing first-time surgery for uni- or bilateral cSDH. Hematoma volumes were m

Boron-doped diamond (BDD) films were synthesized via microwave plasma-enhanced chemical vapor deposition at five boron-to-carbon ratios to investigate dopant effects on perfluorooctanoic acid (PFOA) electrooxidation and electrode stability. Raman spectroscopy revealed that excessive boron (≥10k ppm) produced sp²-rich regions indicative of structural degradation. Electrodes optimized at ∼10k ppm bo

In software development, sampling inspection is applied during the development process, as the production process for software is trivial. In software inspection, which is a manual scrutiny of software code or specifications, sampling is applied to estimate the number of remaining faults and to guide which parts of the artifact to inspect. Capture–recapture techniques are used in the fault content

In the last decade, the idea of total defence – a whole-of-society approach integrating civilian and military capabilities – has gained renewed prominence in Europe, including within the European Union (EU). Concurrently, the concept of strategic autonomy – the EU’s ability to act independently – has emerged as a central feature in its security policy, driving ambitions for ‘a quantum leap forwardIn the last decade, the idea of total defence – a whole-of-society approach integrating civilian and military capabilities – has gained renewed prominence in Europe, including within the European Union (EU). Concurrently, the concept of strategic autonomy – the EU’s ability to act independently – has emerged as a central feature in its security policy, driving ambitions for ‘a quantum leap forward

Introduction: Target volume delineation is crucial in breast cancer radiotherapy planning but involves significant interobserver variability. Deep learning (DL) models may reduce this variability, saving time and costs. However, current DL-models do not consider clinical data, such as tumor location and patient comorbidity, to adjust the target and reduce dose to organs at risk (OAR). This study c

Background and objective: The European Council advises evaluating the feasibility of organized prostate cancer testing (OPT) programs, but it is unclear whether results from screening trials can be replicated in population-based testing. The aim of this study is to compare magnetic resonance imaging (MRI) assessments and biopsy outcomes with and without a central review in two Swedish OPT programs

This work presents the development and evaluation of a Direct Membrane Filtration (DMF) concept for municipal wastewater treatment, integrating microsieving, microfiltration/ultrafiltration (MF/UF), and downstream polishing with activated carbon. DMF enables the efficient separation of particulate organic matter directly from raw wastewater, producing a retentate suitable for enhanced biogas produ

This study provides a systematic overview of Natural Language Processing (NLP)-based frameworks for Cyber Threat Intelligence (CTI) and the early prediction of cyberattacks in Industry 4.0. As digital transformation accelerates through the integration of IoT, SCADA, and cyber-physical systems, manufacturing environments face an expanding and complex cyber threat landscape. Following the PRISMA 202

Purpose: Among visually Tau-PET-positive scans, large variation exists in the size of the visually tau-positive area. Here, we propose a metric quantifying the spatial extent of visual Tau-PET-positivity, termed “TAU-SPEX”, and evaluate associations with visual read status, neurofibrillary tangle (NFT) pathology at autopsy, and cognition. Methods: [18F]flortaucipir data from 1,645 participants (ag

Objective: The aim of this study was to assess the risk of radiation-induced cancer development in patients that have undergone an infrarenal EVAR, stratifying the relative contributions of the procedure and the preoperative and postoperative CTAs. Methods and Materials: The organ-specific absorbed radiation doses from CTA and the EVAR procedure were estimated from the radiation exposures of 95 an

Health-related quality of life (HRQoL) has been shown to predict overall survival (OS) in several different malignancies, but not in patients with small intestinal neuroendocrine tumours (siNET). We evaluated the influence of HRQoL on survival in patients with siNET. We included 85 patients with advanced siNET who completed the validated HRQoL instruments, EORTC QLQ-C30 and GI.NET21. We used Cox p