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Acute myeloid leukaemia (AML) is an aggressive blood cancer characterized by the unregulated proliferation of immature myeloblasts. Gene mutations have been shown to have a large effect on pathogenesis, inter-tumour heterogeneity and clinical outcomes in AML1, 2, 3, 4, 5, 6, 7–8; however, the role of epigenetic alterations in these respects has been investigated less extensively. Here we use ATAC-
Background and Objectives: Psychosocial interventions support informal caregivers of people with dementia, but their impact on anticipatory grief and related health outcomes remains unclear. This review examines the effectiveness of different psychosocial approaches in addressing these outcomes.Research Design and Methods: A systematic review and meta-analysis were conducted following PRISMA guide
Pharbitis nil (L.) Choisy is a traditional medicinal plant exhibiting broad-spectrum pharmacological effects, including anti-cancer, renoprotective, and laxative effects; insecticidal activity; and antifungal, anti-inflammatory, antioxidant, neuroprotective, and hepatoprotective actions. In this study, 11 compounds were isolated from the seeds of the plant and structurally characterized. These inc
Background: The aim was to evaluate bias and precision for 177Lu-activity-quantification using window-based scatter compensation in a ring-configured CZT gamma camera (StarGuide™, GE HealthCare). This paper extends a previous study by applying modified scatter compensation (MSC) methods introduced with the StarGuidePlus upgrade. The modified methods account for contamination of scatter windows by
Background: Meningioma, the most prevalent brain tumor in adults, is predominantly benign and often treated with radiotherapy and/or surgery, generally with positive treatment outcomes. Radiotherapy can be administered using either conventional radiotherapy (CRT) or proton beam therapy (PBT). The treatment can cause chronic symptoms such as headache, fatigue, and neurocognitive impairments that ca
Abstract – Introduction: Hypochondriasis is a prevalent psychiatric condition associated with substantial individual suffering and healthcare utilization. Despite its clinical importance, little is known about its etiology, and the extent to which familial and genetic factors contribute to its development remains unclear. Methods: In this population-based cohort study, we identified 5, 809, 325 in
The slow progression of Alzheimer’s disease (AD) poses a challenge for the quantification of early disease-driven cognitive decline. Here, we show that frequently administered remote and unsupervised digital cognitive assessments can detect differences in cognitive decline within 30 weeks in early AD. The sample comprised 202 individuals (52–85 years old) recruited from longitudinal observational
Rationale: Clinical interest in psilocybin-assisted rehabilitation for motor disorders is growing. However, psilocybin’s motor effects are under-researched, and quantifying them is essential for assessing treatment risks and outcomes. Objectives: This study aims to clarify whether acute effects of psilocybin disrupt established patterns of manual dexterity and coordination. Specifically, we evalua
Background Since its emergence, the COVID-19 infection has led to significant morbidity and mortality worldwide. Early identification of patients at risk for severe disease is essential for more effective triage, timely therapeutic intervention, and optimal resource allocation. Differences in population characteristics may contribute to variability in disease outcomes, which emphasizes the need fo
Perceived safety in urban areas depends on factors operating across multiple spatial scales. Nevertheless, most studies address only one scale at a time. The methodological contribution of this work lies on the introduction of a multi-scale approach for the analysis of perceived in urban areas. This approach includes city, neighbourhood, and individual scales. The overall goal is to identify the k
Study region: The Limpopo River Basin (LRB) is a transboundary catchment in Southern Africa spanning South Africa, Botswana, Zimbabwe, and Mozambique. The lower basin, particularly the Chókwè–Xai-Xai floodplain in Mozambique, is highly flood-prone due to flat topography, climate variability, and rapid agricultural and settlement expansion. Study focus: This study presents a climate-informed framew
We used national Swedish registry data to investigate the nature of the association between pregnancy and decreased risk for suicide attempt (SA). Analyses included pregnant individuals aged 18–35, biological fathers, and matched controls born 1975–1995. Data were available for between 366,125 and 2,129,244 females (depending on the model) and 359,622 males. We evaluated risk for SA as a function
This exploratory study presents an objective and consistent approach for assessing forest structure across multiple European countries, focusing on the distributions of tree species and tree diameter at breast height (DBH) as assessed by European National Forest Inventories (NFIs) and one landscape inventory. We distinguish six structural classes, ranging from mono-specific plots with a narrow (re
Introduction – Post-acute sequelae of SARS-CoV-2 (PASC) may develop after SARS-CoV-2 infection and cause a wide range of symptoms that can persist for years. Several pathophysiological mechanisms have been proposed, including dysregulation of the complement system. Methods – In this study, we analysed markers of complement activation in a cohort of patients with PASC, up to 33 months after the ini
Background: The participation of nurse leaders in decision-making has been described as vital for healthcare organisations. However, their involvement in health policy-making is still suboptimal and their contribution is frequently unnoticed. This study aimed to understand the contribution of nurse leaders in decision and policy-making during the COVID-19 pandemic to inform future health crisis ma
Breast density, defined as the proportion of breast tissue composed of dense fibroglandular tissue, is a crucial factor in assessing breast cancer risk and significantly impacts the visibility of lesions during mammography screening. We focus on distinguishing between high and low breast density by fine-tuning deep neural networks and on our joint deep and sparse approximation methodology. We eval
Urban vegetation is a critical nature-based solution for mitigating the urban heat island effect, yet its cooling efficacy on road surfaces varies spatially due to differences in vegetation type, structure, and local urban morphology. This study investigates the spatially varying nonlinear cooling effects of differentiated street greenery, including trees, shrubs, and grass, on land surface temper
Trace elements are persistent contaminants that enter bee diets through pollen, nectar, soil-derived particles and atmospheric deposition, yet field-based exposure data for pollinator taxa remain limited. We examined 18 trace elements (Al, As, Ba, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Se, U, V, Zn) in pollen stored by managed western honey bees (Apis mellifera), buff-tailed bumble bees (Bomb
Background: Policy implications are seldom more than a paragraph or two at the end of empirical papers. The aim was therefore to explore social determinants of mental health across life through qualitative analysis of meta-synthesis of empirical publications from a 27-year school-leaver cohort. From the actionable empirical results, we suggest policies for primary prevention aimed at equitable men
Incretins such as glucagon-like-peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) play crucial roles in postprandial glucose management. Glucagon-like-peptide 1 and GIP stimulate insulin release in conjunction with meals and are responsible for up to 75% of the insulin secretion. Incretins are therefore very important for maintenance of normal blood glucose levels. Dairy foo
