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BACKGROUND AND OBJECTIVES: Cerebral small vessel disease (CSVD) is associated to cognitive decline and dementia. Neuroimaging changes of CSVD are highly prevalent above 80 years. Only few studies report on incidence of CSVD in high age. We have investigated the incidence and prevalence of magnetic resonance imaging (MRI) markers of CSVD and risk factors in the general older population.METHODS: As

Low-carbon behaviour changes are essential for achieving the Paris Agreement to limit global warming to 1.5° Celsius. Increasingly, it is recognised that such behaviour changes cause further effects in individuals' lifestyles, which are important to understand for the success of such low-carbon behaviour changes. Rebound effects can occur that undermine the carbon savings, and individual well-bein

In Alzheimer’s disease (AD), β-amyloid and tau accumulate in the brain leading to neuronal loss and cognitive decline. The associations between these protein aggregates and their downstream effects are clear but not perfect, with other, largely unknown, factors explaining the discrepancy. This phenomenon has been described within the resilience framework.We aimed to explore whether demographic fac

Iron-centered N-heterocyclic carbene compounds have attracted much attention in recent years due to their long-lived excited states with charge transfer (CT) character. Understanding the orbital interactions between the metal and ligand orbitals is of great importance for the rational tuning of the transition metal compound properties, e.g., for future photovoltaic and photocatalytic applications.

Att bli förälder är en stor omställning i livet och kan förändra arbetssituationen, relationer och den egna personliga utvecklingen. Föräldraskap upplevs ofta som starkt könsbundet och kvinnor över hela världen tar på sig mer hushållsarbete och barnomsorg än män, även i Sverige. Trots att Sverige har en generös och könsneutral föräldraledighet finns det fortfarande ojämlikheter i hur föräldrar hanThis thesis explored gendered parenthood and parents’ experiences of their work- family interface through the COVID-19 pandemic. This thesis draws on decades of analysis of gendered labor division, father involvement, and the work-family interface to understand developments and tensions before the pandemic. It then positions the pandemic as a global ‘developmental event’ due to the restrictions im

Purpose: Cognitive function is often impaired for cardiac arrest (CA) survivors due to hypoxic-ischemic brain injury. Whether cognitive impairment at hospital discharge is associated with recovery defined as functional status and fatigue measured at 1-month post-discharge is not known.Methods: Consecutive CA patients admitted at an academic center (May 14, 2021–June 23, 2023) were assessed for cogPurpose: Cognitive function is often impaired for cardiac arrest (CA) survivors due to hypoxic-ischemic brain injury. Whether cognitive impairment at hospital discharge is associated with recovery defined as functional status and fatigue measured at 1-month post-discharge is not known.Methods: Consecutive CA patients admitted at an academic center (May 14, 2021–June 23, 2023) were assessed for cog

he term “existential” is nowadays used in connection with different kinds of threat, risk and hazard–sustainability discourse included. Loss of certain forms of existence, potential, conditions and values have all been claimed to be incompatible with existential dimensions of sustainability (or “existential sustainability”, for short). In order to clarify the notion(s) of existential sustainabilitThe term “existential” is nowadays used in connection with different kinds of threat, risk and hazard–sustainability discourse included. Loss of certain forms of existence, potential, conditions and values have all been claimed to be incompatible with existential dimensions of sustainability (or “existential sustainability”, for short). In order to clarify the notion(s) of existential sustainabili

Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this stu

This introduction to this special issue of Inquiry looks at recent work in the philosophy of conspiracy theory theory. Looking at two related worries expressed in the wider conspiracy theory theory (the academic study of conspiracy theories) – the Problem of Conspiracy Theories and the Problem of Conspiracy Theorists – this special issue argues that recent work in the philosophy of conspiracy theo

Despite the clear restrictive guidelines about the use of modern handheld devices among children younger than 2 years, parents are seen to extensively use these devices with their infants. However, parents’ perceptions in this regard remain unclear and underexplored especially, in the context of South Asian cultures such as Pakistan. This qualitative study aims to explore parents’ perceptions rega

This article reports conclusions from a three-year research project on Swedish public libraries. The focus of the project is on librarians experience of libraries mission to promote democracy when democratic norms and values are challenged politically by radical right populism. Results of a longitudinal survey point to stability and lack of political interest over time, but increased societal polaThis article reports conclusions from a three-year research project on Swedish public libraries. The focus of the project is on librarians experience of libraries mission to promote democracy when democratic norms and values are challenged politically by radical right populism. Results of a longitudinal survey point to stability and lack of political interest over time, but increased societal pola

Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal

Starting from the premise that English negative modal contractions constitute partly variable patterns of associations that include both the preceding subject and the following verb infinitive, the study sets out to investigate distributional differences between can’t, shouldn’t, and won’t and their corresponding uncontracted parent forms. Given that some configurations are assumed to correlate wiStarting from the premise that English negative modal contractions constitute partly variable patterns of associations that include both the preceding subject and the following verb infinitive, the study sets out to investigate distributional differences between can’t, shouldn’t, and won’t and their corresponding uncontracted parent forms. Given that some configurations are assumed to correlate wi

Entrenchment of multi-word sequences is known to shape native language competence, but there is debate about how (much) it affects L2 speakers. We investigate advanced English learners’ receptive processing of multi-word sequences with a word-monitoring experiment. The effect of reduction on recognition of the word to was tested in English V-to-Vinf constructions of varying surface frequencies and

The molecular mechanisms that drive the onset and development of osteoarthritis (OA) remain largely unknown. In this exploratory study, we used a proteomic platform (SOMAscan assay) to measure the relative abundance of more than 6000 proteins in synovial fluid (SF) from knees of human donors with healthy or mildly degenerated tissues, and knees with late-stage OA from patients undergoing knee repl

OBJECTIVE: To investigate the occurrence of meniscal calcifications in individuals with and without knee osteoarthritis (OA). Additionally, we aim to identify the specific types of calcifications: basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP).METHOD: We analysed 82 meniscal posterior horn samples (medial and lateral) collected from 41 human subjects. Among them, 20 indivi

Employing the Foucauldian term ‘conduct’, this article explores how social resilience and morale became a target of state intervention in Denmark during the Cold War. ‘Psychological defence’ was a Cold War phenomenon designed to bring an imagined future war into a space of control as well as a tool for the authorities’ exercise of power in case another world war became a reality. Advocating a methEmploying the Foucauldian term ‘conduct’, this article explores how social resilience and morale became a target of state intervention in Denmark during the Cold War. ‘Psychological defence’ was a Cold War phenomenon designed to bring an imagined future war into a space of control as well as a tool for the authorities’ exercise of power in case another world war became a reality. Advocating a meth

Objective To assess the intervention fidelity and explore contextual factors affecting the process of implementing a mobile phone text messaging intervention in improving adherence to and retention in care among adolescents living with HIV, their families and their healthcare providers in southern Ethiopia. Design A convergent mixed-methods design guided by the process evaluation theoretical frame