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Purpose: Deficiency of interleukin-1 receptor antagonist (DIRA) is a rare life-threatening autoinflammatory disease caused by autosomal recessive mutations in IL1RN. DIRA presents clinically with early onset generalized pustulosis, multifocal osteomyelitis, and elevation of acute phase reactants. We evaluated and treated an antibiotic-unresponsive patient with presumed DIRA with recombinant IL-1Ra
Background. Polypharmacy is known to increase the risk for drug-related problems, and some drugs, potentially inappropriate medications (PIMs), are especially troublesome. Objective. To analyse the effects on prescription of PIMs of the SäKLäK project, an intervention model created to improve medication safety for elderly patients in primary care. Method. The SäkläK project was a multiprofessional
Aims/hypothesis: Inflammasome activation and subsequent IL-1β production is a driver of islet pathology in type 2 diabetes. Oligomers, but not mature amyloid fibrils, of human islet amyloid polypeptide (IAPP), which is co-secreted with insulin, trigger NOD-like receptor pyrin domain containing-3 (NLRP3) inflammasome activation. C4b-binding protein (C4BP), present in serum, binds to IAPP and affect
Title: Verbal encoding fMRI paradigm adds complementary information to cerebrallanguage lateralization.Purpose: To explore two conceptually different fMRI paradigms’ ability to lateralizelanguage.Methods: A verbal encoding paradigm and a word generation task were performed bysix patients (four right-handed) with therapy-resistant temporal lobe epilepsy (TLE),and by ten healthy individuals (five ri
The stone house in Färlöv. A few years ago, in 2009, a previously unknown stone building was found west of the Romanesque church in the village of Färlöv, north-east Scania. In 2011 the Historical Museum in Lund together with the University College of Kristianstad started a research project on the building and its surroundings. Archaeological excavations have shown that the house was built most l
Many separate-sexed organisms have sex chromosomes controlling sex determination. Sex chromosomes often have reduced recombination, specialized (frequently sex-specific) gene content, dosage compensation and heteromorphic size. Research on sex determination and sex chromosome evolution has increased over the past decade and is today a very active field. However, some areas within the field have no
The reconstruction and calibration algorithms used to calculate missing transverse momentum (ETmiss) with the ATLAS detector exploit energy deposits in the calorimeter and tracks reconstructed in the inner detector as well as the muon spectrometer. Various strategies are used to suppress effects arising from additional proton–proton interactions, called pileup, concurrent with the hard-scatter pro
We establish Lieb–Thirring power bounds on discrete eigenvalues of Jacobi operators for Schatten class complex perturbations of periodic and more generally finite gap almost periodic Jacobi matrices.
We demonstrate a novel 3D NNC magic angle spinning NMR experiment that generates 15N-15N internuclear contacts in protein systems using an optimized 15N-15N proton assisted recoupling (PAR) mixing period and a 13C dimension for improved resolution. The optimized PAR condition permits the acquisition of high signal-to-noise 3D data that enables backbone chemical shift assignments using a strategy t
Small heat-shock proteins (sHsps) prevent aggregation of thermosensitive client proteins in a first line of defense against cellular stress. The mechanisms by which they perform this function have been hard to define due to limited structural information; currently, there is only one high-resolution structure of a plant sHsp published, that of the cytosolic Hsp16.9. We took interest in Hsp21, a ch
The current virtualization solution in the Cloud widely relies on hypervisor-based technologies. Along with the recent popularity of Docker, the container-based virtualization starts receiving more attention for being a promising alternative. Since both of the virtualization solutions are not resource-free, their performance overheads would lead to negative impacts on the quality of Cloud services
The use of diffuse, highly reflective optical components, in particular, a hemispherical BaSO4 diffuser, at the point of light injection into non-transparent or turbid media was evaluated as a means to increase the measurement sensitivity of spectroscopic absorption measurements. By performing the light injection from, e.g., an optical fiber through a component designed to make the light diffuse a
In this study, the interferometric coherence calculated from 12-day Sentinel-1 image pairs was analysed in relation to mowing events on agricultural grasslands. Results showed that after a mowing event, median VH (vertical transmit, horizontal receive) and VV (vertical transmit, vertical receive) polarisation coherence values were statistically significantly higher than those from before the event
The aim of this study was to characterize young dating violent offenders (DVO), and to compare them to the general population and to young offenders with violent crimes directed against other victims. We have used data from the Development of Aggressive Antisocial Behaviour Study, in all 264 young men, 18 to 25 years, convicted of violent crimes and imprisoned in the Western Region of the Swedish
Transboundary environmental problems pose a specific challenge to the international legal system, as they often demand instruments providing for collective and far-reaching measures on a global scale. Such measures may interfere with other areas of international law, including trade law, human rights law and international humanitarian law (IHL), which may permit conflicting behaviour. The interfer
This article analyses the application of the 1972 United Nations Educational, Scientific and Cultural Organization (UNESCO) World Heritage Convention (the WHC) in the context of the armed conflicts that have taken place in the Virunga National Park (the Park), a natural world heritage site in the Democratic Republic of the Congo (the DRC). Instead of addressing wartime environmental damage under t
Proton exchange membrane fuel cells have been promoted due to improved breakthrough and increased commercialization. The assembly pressure put on a single cell and a fuel cell stack has important influence on the geometric deformation of the gas diffusion layers (GDLs) resulting in a change in porosity, permeability, and the resistance for heat and charge transfer in proton exchange membrane fuel
This chapter examines how international environmental law pertains during and in the transition phase from armed conflict to peace. I argue that environmental treaties have the ability to fill an institutional and a legal gap, particularly in a post-conflict context, which is often characterized of institutional collapse and break down of rule of law. Environmental treaties could therefore be of r
2D perovskites have recently been shown to exhibit significantly improved environmental stability. Derived from their 3D analogues, 2D perovskites are formed by inserting bulky alkylammonium cations in-between the anionic layers. However, these insulating organic spacer cations also hinder charge transport. Herein, such a 2D perovskite, (iso-BA)2(MA)3Pb4I13, that contains short branched-chain spac
Ratios of top-quark pair to Z-boson cross sections measured from proton-proton collisions at the LHC centre-of-mass energies of s=13 TeV, 8 TeV, and 7 TeV are presented by the ATLAS Collaboration. Single ratios, at a given s for the two processes and at different s for each process, as well as double ratios of the two processes at different s, are evaluated. The ratios are constructed using previo
