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Managing hemophilia becomes particularly difficult in patients with inhibitory antibodies, especially in those requiring surgery or with refractory bleeding events. Equally challenging are those patients who develop autoantibodies against factor VIII (FVIII) in the absence of a prior history of FVIII deficiency (acquired hemophilia). Physicians seeking both short- and long-term treatment strategie
The monoclonal antibody 10E4, which recognizes an epitope supposed to contain N-unsubstituted glucosamine, is commonly used to trace heparan sulfate proteoglycans. It has not been fully clarified if the N-unsubstituted glucosamine is required for antibody recognition and if all heparan sulfates carry this epitope. Here we show that the epitope can contain N-unsubstituted glucosamine and that nitri
1 The immunomodulator Linomide has been shown to protect against septic liver injury by reducing hepatic accumulation of leukocytes although the detailed anti-inflammatory mechanisms remain elusive. This study examined the effect of Linomide on the production of CXC chemokines, including macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (KC) and interleukin-
A high precision, time-of-flight hodoscope has been constructed to analyse the secondary pion beam at GSI, Darmstadt. The hodoscope comprises three scintillator planes with the individual scintillator rods read out by photomultipliers in both ends. A new active base of the emitter follower type has been developed for stabilization of voltages at the last dynodes of the photomultiplier. The time re
Control methods are being used increasingly for uncertainty management and QoS in modern web server systems. Previous approaches have suggested combined feed-forward and feedback control strategies, using queuing theory for feed-forward delay prediction. While queuing theory allows one to predict delay as a function of arrival and service rates, the prediction applies only to long-term averages, a
In this paper, a number of challenges, which need to be overcome if multivariate monitoring of wastewater treatment operation is to be successful, are presented. For each challenge, one or several solutions are discussed. The methodologies are illustrated using an example from full-scale wastewater treatment operation. Some guidelines regarding choices of methods and implementation aspects are giv
Popular Abstract in Swedish Medievärlden är idag föremål för drastiska förändringar. Förutom de traditionella medierna såsom böcker, TV och radio, introduceras interaktiva digitala medier. Dessa förändringar berör inte mins barnens och ungdomarnas liv. Allteftersom de får tillgång till sofistikerade elektroniska och digitala medier blir deras fritid alltmer teknifierad. Vi är all medvetna om hur mWe are all aware of how many different media have become a familiar equipment in the home, perceived as any other furnityre. The media have become more or less unconsciously intertwined in everyday routines. As the media environment is continously in a phase of transformation, it is crucial to gain knowledge about children´s and adolescents´own understanding and interpretation of their mediarelate
I sin avhandling i historia undersöker Larsson mötet mellan den kyrkliga överheten och församlingsborna vid biskopsvisitationerna i Växjö stift 1652–56, 1691–1702 och 1750–59. Han söker fånga stiftspartikularismen före 1686 års kyrkolag, vilket genomslag lagen sedan fick, och vad som hände när kyrkan fick ”konkurrens av andra religiösa rörelser”. De båda första tidssnitten är naturliga, men det tr
We present a detailed chemical analysis of 22 stars along thecolour-magnitude sequence of the intermediate-age (1.7 Gyr) open clusterIC 4651, based on high-resolution, high S/N ratio spectra from UVES/VLT.IC 4651 thus becomes one of the few open clusters for which a detailedcomposition analysis exists for stars spanning 3.5 mag, from solar-typemain-sequence stars to giants above the RGB clump. In
The aim of this report has been to perform a risk analysis of ABB Automation Products activity in building 358. The risk analysis consequences are expressed in economical terms and the measurement of the risk is presented as the expected annual cost due to fire. The model used is based on an event tree which describes what happens if a fire breaks out in the building. The effect of different fire
Background and purpose: A new concept for the inhibition of CGRP signalling has been developed by interaction with the CGRP molecule per se by using a CGRP antibody or a CGRP binding RNA-Spiegelmer (NOX-C89). We have compared these CGRP scavengers with two known receptor antagonists (CGRP8-37 and BIBN4096BS) on CGRP-induced relaxations in the rat middle cerebral artery (MCA). Furthermore, the role
Background: As a secreted protein, cystatin C is assumed to play its role in the extracellular compartment, where it can inhibit virtually all cysteine proteases of families C1 ( cathepsin B, L, S) and C13 ( mammalian legumain-related proteases). Since many of its potential target enzymes in the eye reside in intracellular compartments, we sought evidence for a cellular uptake of the inhibitor in
Contrast-enhanced magnetic resonance angiography (CE-MRA) is a diagnostic method for imaging of vascular structures based on nuclear magnetic resonance. Vascular enhancement is achieved by injection of a contrast medium (CM). Studies were performed using two different types of CM: conventional paramagnetic CM, and a new type of CM based on hyperpolarized (HP) nuclei. The effects of varying CM con
The activities of hepatic lipase and of lipoprotein lipase, the elimination rate of exogenous triglyceride and the cholesterol esterification rate were determined and related to plasma lipoprotein concentrations in 16 patients before and after treatment for hyperthyroidism. The activity of hepatic lipase was significantly higher (65%) before than after treatment, while the activity of lipoprotein
1. To investigate further the release, localization and identity of a non-nitrergic mediator of smooth muscle relaxation in the female pig urethra, we studied the effects of drugs acting at alpha 2-adrenoceptors or K+ channels, the effects of capsaicin and chemical sympathectomy, and the actions of several transmitter candidates. 2. Electrical field stimulation (EFS; frequencies above 12 Hz) of sp
Popular Abstract in Swedish Den här avhandlingen sätter forskningen om hettitiska ritualer in i en bredare kontext av historisk religionsantropologi. Med sin teoretiska bas i Pierre Bourdieus praxisteori undersöker den dels hur diskursen om hettitiska ritualer och religion har förts inom hettitologi och religionshistoria, dels hur en alternativ diskurs om de så kallade ”besvärjelseritualer” kan föThis thesis deals with the recent discourse about Hittite ritual and religion and assumes an alternative approach. It analyses how the most important researchers in the fields of Hittitology and History of Religions, who have been working with Hittite rituals and religion, describe and explain the rituals. Their implicit or explicit theories underlying the discourse are explored. The restraining e
