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Mitochondrial permeability transition (MPT) is a nonselective inner membrane permeabilization that contributes to neuronal cell death under circumstances such as brain trauma, ischemia, and hypoglycemia. Here we study the participation of MPT and the Bcl-2-sensitive apoptotic cell death pathway in glutamate receptor-mediated excitotoxicity. Intrastriatal infusions of the N-methyl-D-aspartate (NMDA
Smoking is a well-known risk factor for cardiovascular disease, although understanding of the pathophysiological mechanism is incomplete. The effect of heavy smoking, for more than 20 years and of 20 cigarettes per day, on aortic stiffness was studied in women (n = 23, age range 43-61 years) and men (n = 21, age range 43-61 years) who smoked but were otherwise healthy and compared with a healthy r
The European integration process both affirms and challenges gender relations in Europe. Yet integration theories have contributed little to understanding gender dynamics. The article presents a feminist critique of integration theories and argues that they have failed to look at how gender relations impact the 'driving forces' of European integration. This lacuna is attributed t t he implicit mal
ELT science drivers stress aperture, Strehl ratio, PSF definition and stability, field of view, wavelength range, flexibility, low polarisation and thermal emittance, auxiliary instruments, site and infrastructure. Applicable science categories are planets and planetary systems, stars and stellar systems, galaxies and galaxy clusters, and cosmology. ELT observations are needed for our own and othe
We investigated the orientation of juvenile pied flycatchers, Ficedula hypoleuca, during autumn migration in south Sweden using orientation cage experiments, to study the relative importance of visual and magnetic information at sunset. We performed cage tests under 12 experimental conditions that manipulated the geomagnetic and visual sunset cues available for orientation: natural clear skies in
Azimuthal correlations of jet-induced high-p(T) charged hadron pairs are studied at midrapidity in Au+Au collisions at root s(NN)=200 GeV. The distribution of jet-associated partner hadrons (1.0 < p(T)< 2.5 GeV/c) per trigger hadron (2.5 < p(T)< 4.0 GeV/c) is found to vary with collision centrality, in both shape and yield, indicating a significant effect of the nuclear collision medium on the jet
Objectives: The study examined the relation between daily workhours and the occurrence of neck-shoulder or back pain in physically demanding care work. Methods: Unpublished data were obtained from three intervention projects in care institutions. The projects had been conducted independently in Oslo (46 participants, 175 referents before and 158 referents after the intervention), Helsingborg (60
The character and quantity of dissolved organic carbon (DOC) were studied in nine small boreal streams and adjacent soils during two years, with focus on the spring snowmelt period. The streams cover a forest-wetland gradient, spanning from 0% to 69% wetland coverage. Lower values of the absorbance ratio measured at 254 nm and 365 nm (A(254)/A(365)), in both soil plots and streams, indicated that
The impedance at frequencies of 1-1000 kHz and dynamic bending storage modulus measured by the vibrating reed method were compared for potato tuber tissue, which had been processed by various methods. Raw potato tuber tissue strips were either heated for 30 min up to 100°C or frozen-thawed. Some samples were osmotically dehydrated in a mannitol solution up to a concentration of 0.7 mol/l. The elec
Amplified fragment length polymorphisms (AFLP) are dominant markers frequently used to build linkage maps where heterozygosity could be inferred by a backcross breeding strategy. In the present study, we describe the utilization of an unmanipulated great reed warbler, Acrocephalus arundinaceus pedigree to infer heterozygous genotypes of AFLP markers in order to map these markers to a partial linka
Aims: To study the impact of social participation, trust, and the miniaturization of community, i.e. high social participation/low trust, on the risk of high alcohol consumption. Methods: The Scania 2000 public health survey is a cross-sectional, postal questionnaire study. A total of 13 604 persons aged 18–80 years were included. A logistic regression model was used to investigate the association
The objective of the present study was to determine whether a systematic optimization of Morris water maze (mwm) testing parameters could reveal a significant role of the septohippocampal cholinergic system in spatial working memory. Young adult rats were lesioned using 192 IgG-saporin infused bilaterally into the medial septum. Lesions were near complete as measured by choline acetyltransferase (
In the present study, the objective was to evaluate the long-term metabolic impact of adding lactic acid to a bread-based diet in obese, hyperinsulinaemic Zucker (fa/fa) rats. All diets were based on a white wheat bread, and the lactic acid was added either prior to, or after the baking process. In addition, a diet with addition of Lactobacillus plantarum 299v was included to investigate the possi
This work describes a mediated amperometric method for simultaneous real-time probing of the NAD(P)H availability in two different phenotypes, fermentative and respiratory, of the phosphoglucose isomerase deletion mutant strain of S. cerevisiae, EBY44 [ENY.WA-1A pgi1-1D::URA3], and its parental strain, ENY.WA-1A. The developed method is based on multichannel detection using microelectrode arrays.
Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the individua
