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There is great interest in therapeutically harnessing endogenous regenerative mechanisms to increase the number of β cells in people with diabetes. By performing whole-genome expression profiling of zebrafish islets, we identified 11 secreted proteins that are upregulated during β-cell regeneration. We then tested the proteins' ability to potentiate β-cell regeneration in zebrafish at supraphysiol
Although compensatory islet hyperplasia in response to insulin resistance is a recognized feature in diabetes, the factor(s) that promote β cell proliferation have been elusive. We previously reported that the liver is a source for such factors in the liver insulin receptor knockout (LIRKO) mouse, an insulin resistance model that manifests islet hyperplasia. Using proteomics we show that serpinB1,
Doctoral education is a critical mission of higher education institutions (HEIs), and supervisors of PhD students have a prominent role in the process. The relevance of their role in a successful PhD experience and outcome raises an important question: how are PhD supervisors trained for their roles in the doctoral education process? In this work, we aimed to identify the formal training component
Occupational balance is associated with better quality of life and recovery in mental health service users; however, research focusing on such relationships among older adults within this group remains scarce. This explorative cross-sectional study examined relationships between occupational balance and quality of life and recovery in 49 older mental health service users, while also investigating
γ-Tubulin (TUBG) is best known for organizing microtubules at centrosomes, but our work points to broader roles in chromatin and mitochondria. Our Communications Biology study extends this picture to centromeres and micronuclei—two unexpected contexts for TUBG.
This research conducted two vignette-based experiments designed to examine the potential role of social norms to motivate engagement with car sharing service (CSS) adoption in Spain. The analysis answered two research questions: a) to what extent do descriptive and injunctive social norms promote the willingness to adopt CSS, and b) what is the influence of injunctive norms on the willingness to u
A longstanding but untested hypothesis proposes that reduced bee visitation in tropical montane cloud forests has repeatedly driven the evolution of hummingbird pollination. Here, we test whether recently diverged bee and hummingbird pollination syndromes in two sister species are adapted to their pollination environments, and whether this reflects declining bee activity at higher elevations. Alte
Circular economy (CE) behaviors, such as reuse, repair, and sharing, are crucial to sustainable consumption; however, how and when such behaviors influence product users or consumers' personal well being remain underexplored. Specifically, limited insights exist regarding how engagement may foster feelings of enjoyment, a sense of mastery, or social belonging, as well as the contextual conditions
The fossil record offers a unique window into patterns of extinction and biodiversity recovery over deep time, and recent advances in analytical methods have significantly enhanced this research field. Our analysis of an updated dataset that includes 50 terminal taxa and 175 fossil occurrences of Ophiacodontidae, Edaphosauridae, and Sphenacodontidae (OES grade hereafter) using a recent implementat
Immunotherapy has reshaped melanoma treatment, yet the majority of patients fail to respond or develop resistance. Nerve growth factor receptor (NGFR/p75NTR/CD271) has been linked to melanoma aggressiveness and therapeutic resistance, but the underlying mechanisms remain unclear. Here, we demonstrate that pharmacologic inhibition of NGFR with THX-B significantly reduces distant metastasis and rest
Introduction: Suicidal behaviors are complex phenotypes, often studied in the context of psychiatric comorbidities. However, little is known about the specific roles of psychiatric disorders and the etiology of suicidal behaviors that occur outside the context of psychiatric comorbidities. Methods: We included 926,040 individuals born 1980–1990 from the Swedish national registries. We conducted se
BACKGROUND: Bone mineral density (BMD) is compromised in patients with systemic sclerosis (SSc) compared to the background population, yet the underlying disease related factors are less known. This study evaluates SSc disease-related features and predictability for BMD along with established risk factors for low BMD in SSc patients compared to controls.METHODS: The study includes 211 SSc patients
The optical elements that can combine memory and signal modulation have become a topic of interest in the field of neuromorphic computing systems. In particular, the optical analogue of a memristor called memlumor exhibits promising features in which the change of the output luminescence depends not only on the excitation light signal but also on the state of the material. Metal halide perovskite
This chapter will review the three following topics: Nutrient cycling at three scales and integration. Specifically, what organisms are involved? What are the main drivers of the cycles of nutrients at the three scales and how these cycles interact? Resilience to disturbance and ecosystem retrogression Drivers of site productivity including ecosystem conditions and effects of management.
Background and aim: Vitamin K has been proposed to have a preventive effect against arterial calcification through activation of the vitamin K dependent proteins and potentially protect against progression of atherosclerosis. Our aim was to assess the association between vitamin K status and vascular health in a general elderly population. Methods and results: In a cross-sectional study, the vitam
Introduction: The validity of hypertensive disorders of pregnancy (HDP), including preeclampsia, gestational hypertension, and chronic hypertension, is essential for both clinical management and research. The Swedish Pregnancy Register automatically retrieves diagnostic codes based on the Swedish version of the International Classification of Diseases 10th revision (ICD-10), as recorded in antenat
This paper examines how political populist support and income inequality are associated with the ecological footprint and its two sub-components: the carbon footprint and the non-carbon footprint (land and water use). Using a panel dataset covering 16 high-income European countries from 1990 to 2022, we estimate a dynamic panel error correction model. Three findings stand out. Right-wing populist
Background: The potential for intellectual property (IP) and open science (OS) to be used together for knowledge valorisation is increasingly discussed within research policy, yet their practical alignment remains limited. While researchers and research managers often regard IP and OS as potentially complementary, uncertainty persists about how to integrate them effectively in real-world contexts.
