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Key recommendationsPastureland restoration must be implemented to reduce dependency oncoping mechanisms such as emergency feeding, mechanized transport andintense workloads. These coping mechanisms are increasingly used to dealwith the cumulative effects of encroachments from competing land uses,predator pressure, and the impacts of climate change on snow conditions.Vigorous thinning of dense, man
BACKGROUND: Postural instability is considered a late complication of Parkinson’sdisease (PD). However, growing evidence shows that balance and gait problems mayoccur early in the disease.OBJECTIVE: To describe balance, gait, and falls/near falls in persons with newlydiagnosed, untreated PD (“de novo”), and to compare this with persons with mildmoderatePD (Later PD). In addition, we evaluated diffBackgroundPostural instability is considered a late complication of Parkinson’s disease (PD). However, growing evidence shows that balance and gait problems may occur early in the disease.ObjectiveTo describe balance, gait, and falls/near falls in persons with newly diagnosed, untreated PD (“de novo”), and to compare this with persons with mild-moderate PD (Later PD). In addition, we evaluated dif
Local genetic correlation analysis is an important tool for identifying genetic loci with shared biology across traits. Recently, Border et al. have shown that the results of these analyses are confounded by cross-trait assortative mating (xAM), leading to many false-positive findings. Here, we describe LAVA-Knock, a local genetic correlation method that builds off an existing genetic correlation
This study investigates age-related biases in AI-generated art through a mixed method investigation of images of older and younger individuals. Employing 19 text prompts associated with social exclusion for older adults, we collected 465 images from an AI-art generator, MidJourney, and conducted quantitative and qualitative analyses to understand differences between age group depictions. We used A
En kulturhistorisk perspketivering med plagget Hawaiiskjortan i fokus. Dels beskrivs Hawaiiskjortan som sådan, historisk etablering, i ett internetaionellt såväl som inrikes svenskt läge; dels förs resonemang om Hawaiiskjortans symboliska och betydelseproducerande roll i populärkulturen (TV-serier, filmer, musik av olika slag).
Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the second most common among children. AML is characterized by aberrant proliferation of myeloid blasts in the bone marrow and impaired normal hematopoiesis. Despite the introduction of new drugs and allogeneic bone marrow transplantation, patients have poor overall survival rate with relapse as the major challeng
Ecosystem functioning depends on biodiversity at multiple trophic levels, yet relationships between multitrophic diversity and ecosystem multifunctionality have been poorly explored, with studies often focusing on individual trophic levels and functions and on specific ecosystem types. Here, we show that plant diversity can affect ecosystem functioning both directly and by affecting other trophic
This article takes a cognitive approach to natural concepts. The aim is to introduce criteria that are evaluated with respect to how they support the cognitive economy of humans when using concepts in reasoning and communicating with them. I first present the theory of conceptual spaces as a tool for expressing the criteria. Then I introduce the central idea that natural concepts correspond to con
The description of quantum transport in the strong system-reservoir coupling regime poses a significant theoretical and computational challenge that demands specialized tools for accurate analysis. RealTimeTransport is a new open-source C++ library that enables the computation of both stationary and transient transport observables for generic quantum systems connected to metallic reservoirs. It co
Scholarship on the Jovinianist controversy has shown that the idea of baptism as deeply transformative lay at the heart of Jovinian's thinking. Scholars have likewise held that Jerome, who through his Adversus Jovinianum is our main source to the ideas of Jovinian, did not acknowledge the ecclesiological concerns on which his opponent's argument was based. This article argues, to the contrary, tha
Probabilistic life-cycle consequence (LCCon) analysis (e.g., assessment of repair costs, downtime, or casualties over an asset's service life) can enable optimal life-cycle management of critical assets under uncertainties. This can lead to effective risk-informed decision-making for future disaster management (i.e., risk mitigation and/or resilience-enhancing strategies/policies) implementation.
Soil aggregation is a dynamic process influenced by physical, chemical and biological factors; however, their individual and combined effect on the formation and turnover of aggregates is not well understood. The aim of this study was to examine incorporation of fresh litter inputs of different physicochemical properties including their carbon-to-nitrogen (C/N) ratio – maize (C/N = 12) and straw (
Infectious and parasitic agents (IPAs) and their associated diseases are major environmental stressors that jeopardize bee health, both alone and in interaction with other stressors. Their impact on pollinator communities can be assessed by studying multiple sentinel bee species. Here, we analysed the field exposure of three sentinel managed bee species (Apis mellifera, Bombus terrestris and Osmia
The European standard EN 17037 was first introduced in 2018 with the aim of encouraging building designers to ensure adequate daylight in buildings. Experience has shown that the standard’s criteria for daylight provision are generally perceived to be too challenging, and this in turn has hindered its implementation in national legislations. This article proposes a revised illuminance-based criter
Amplification of the MDM2 and CDK4 genes on chromosome 12 is commonly associated with low-grade osteosarcomas. In this study, we conducted high-resolution genomic and transcriptomic analyses on 33 samples from 25 osteosarcomas, encompassing both high- and low-grade cases with MDM2 and/or CDK4 amplification. We discerned four major subgroups, ranging from nearly intact genomes to heavily rearranged
Ultra-thin high-Al content barrier layers can enable improved gate control and high-frequency operation of AlGaN/GaN high electron mobility transistors (HEMTs) but the precise composition control is very challenging. In this work, we investigate the compositional profiles of AlxGa1−xN/GaN HEMT structures with targeted Al content in the barrier layer, x = 0.50, 0.70, and 1, and thickness in the sub
Metachromatic leukodystrophy (MLD) is a fatal, progressive neurodegenerative disorder caused by biallelic pathogenic mutations in the ARSA (Arylsulfatase A) gene. With the advent of presymptomatic diagnosis and the availability of therapies with a narrow window for intervention, it is critical to define a standardized approach to diagnosis, presymptomatic monitoring, and clinical care. To meet the
Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-Cas9 screen in a human MDS-derived cell line, MDS-L, and identify TOPORS as a loss-of-function target that synergizes with HMAs, reducing leukemic burden and i
