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Chromosomal translocations are key events in cancer, driving oncogenesis by disrupting and deregulating critical genes. While specific tumor-associated translocations are well studied, the frequencies and distributions of most remain unknown. Additionally, the role of chromosomal reshuffling in translocations has received little attention. This study presents data on the chromosomal involvement in
The aim of this study was to investigate the impact of phenol on the precipitation of bovine serum albumin (BSA) and human growth hormone (hGH), in the presence of other excipients frequently used in biological drugs for parenteral delivery. The focus of the study lieson incompatibilities observed in multidose formulations containing non-ionic surfactants and preservatives. Previous research has s
To survive, animals have tuned their behaviors to the socio-environmental conditions offered by their habitats and communities. This also applies to communicative behaviors, which can be simultaneously constrained by a number of external factors. Hence, an animal’s surroundings narrow the optimal parameters for effective communication to well within the limits of what it is capable of producing. I
Establishing robust charging infrastructure is crucial for electric vehicle (EV) adoption. This study addresses the lack of systematic literature reviews examining the global charging infrastructure research landscape with a comprehensive review of English literature published between 2017 and 2023. We screened 12237 records, and analyzed 137 peer-reviewed and 31 grey literature studies. Findings
Combined density functional theory (DFT) and X-ray standing wave (XSW) studies have previously provided evidence for the preferential adoption of an inverted conformation of 2H-TPP on Cu(111) in contrast to the saddle conformation usually favored by porphyrin molecules adsorbed on metals. We experimentally demonstrate, via X-ray photoelectron spectroscopy (XPS) analysis, that the binding energies
Cancer cells in solid tumors experience hypoxia, a condition of low O2 concentration, since their O2 demand exceeds the supply from the surrounding vasculature. However, how these cells adapt to hypoxia requires further elucidation. Here, we use a transparent phosphorescent thin film to visualize the self-generated hypoxia field of prostate cancer cells and quantify local O2 consumption rates, mea
Background and purpose: The recently published Nordic anal cancer group (NOAC) contouring guidelines aim for improved oncological outcomes and reduced toxicity in anal cancer patients treated with radiotherapy. The present work describes how the elective clinical target volume (CTVe) would change when applying the NOAC guidelines instead of the previous Australasian standard. According to the Aust
The first multi-bend achromat based synchrotron MAX IV operates two protein crystallography beamlines, BioMAX and MicroMAX. BioMAX is designed as a versatile, stable, high-throughput beamline catering for most protein crystallography experiments. MicroMAX is a more ambitious beamline dedicated to serial crystallography including time-resolved experiments. Both beamlines exploit the special charact
Objectives To establish the prevalence of clinically significant chronic obstructive pulmonary disease (COPD) and relevant characteristics in individuals with a significant smoking history who are hospitalised for acute myocardial infarction (MI). Design Cross-sectional study. Setting Hospital inpatients at 8 European centres (7 in Sweden, 1 in the UK). Participants 518 men or women (302 in Sweden
Necrotizing enterocolitis (NEC) is probably the most painful intestinal disease affecting infants born preterm. NEC is known to cause highly severe and prolonged pain that has been associated with adverse short- and long-term effects. However, research on pain management in infants with NEC is scarce. This is likely due to its low incidence and very acute occurrence. As a result, the optimal pain
