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In this study, a serial production system consisting of two machines and an intermediate finite buffer is considered. The machines have random processing times, and each machine contains one unit of a common critical component that is subject to random breakdown. Broken components must be replaced from an inventory of ready-for-use spare parts to restore machine functionality. This inventory is re
BACKGROUND: Totally implantable venous access ports (TIVAPs) are essential for administering chemotherapeutic drugs and nutritional support, but carry a risk of infectious complications. We hypothesized that the design of the current port needle (Huber) could facilitate the collection of bacteria from the skin during puncture, potentially introducing them into TIVAPs and causing infections. This s
In this forum, seven scholars discuss Oliver P. Richmond’s The Grand Design: The Evolution of the International Peace Architecture, published in 2022. The editors, Gëzim Visoka and Annika Björkdahl, contextualise the book’s contribution within the broader intellectual framework of Richmond’s thoughts and writings on peace in the context of International Relations. Roland Bleiker examines the book’
The Editor-in-Chief has retracted this article because Fig. 1 and its legend contained data that was published without the owner’s permission or the patient’s consent. Figure 1 has now been removed. Jesper Heldrup, Stefan Schwartz, Etienne Chatelut, Miriam Hwang do not agree to this retraction. Archie Bleyer did not state explicitly whether they agree ot this retraction. Brooke Bernhardt agrees to
Tumor hypoxia plays a critical role in cancer progression and therapeutic resistance. Here, we present a protocol for the self-generation of hypoxia by metastatic cancer cells using phosphorescence-based O2 sensing. We describe steps for phosphorescent film calibration, system assembly, and real-time imaging of hypoxia development. We then detail approaches to spatially map resulting O2 gradients.
Background: The accumulation of amyloid-β1−42 (Aβ1−42) peptides and phosphorylated-Tau181 (p-Tau181) tangles from the preclinical stages of Alzheimer’s disease (AD) has led to a biological definition of the disease. However, among Aβ1−42-positive individuals, cognitive decline onset varies, and some never develop symptoms. Genetic influences on molecular pathways and their interactions with protei
Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the Ethiopia achieved a remarkable episode of agricultural intensification from the mid-1990s to the late-2010s, yet the political mechanisms that enabled this transformation—and the distributional and environmental consequences that followed—remain insufficiently understood. This article ex- amines how political leadership, understood in institutional rather than personalistic terms, shaped both the
Background: Ovarian cancer presents with non-specific symptoms that make early diagnosis challenging and the prognosis poor. Ovarian and endometrial cancers exhibit similar genomic mutations and biomarker profiles. Endogenous volatile organic compounds (VOCs) are products of metabolic activity. In cancer, metabolites increase due to tumour necrosis, leading to cancer-specific VOC patterns. The aim
The preparation of perovskite solar cells from the liquid phase is a cornerstone of their immense potential. However, a clear relationship between the precursor ink and the formation of the resulting perovskite is missing. Established theories, such as heterogeneous nucleation and lead complex colloid formation, often prove unreliable, which has led to an overreliance on heuristics. Most high-perf
Effective coastal exposure assessments are crucial for adaptively managing threats from sea-level rise (SLR). Despite recent advances, global and regional assessments are constrained by omitting critical factors such as land-use change, failing to disaggregate potential impacts by land uses and oversimplifying land subsidence. Here we address these gaps by developing context-specific scenarios to
Background: Out of hospital cardiac arrest (OHCA) is a significant public health problem associated with high mortality and high healthcare costs. The Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) randomised clinical trial showed that targeted mild hypercapnia did not lead to better neurologic outcomes at 6 months compared to normocapnia after OHCA. We aimed to est
Alison Scott–Baumann’s Paul Ricoeur: Empowering Education, Politics and Society employs Ricoeur’s philosophy to unpack contemporary universities’ struggles with polarisation and activism. Though short in form, this rich critical study illuminates how universities understand themselves and why fostering dialogue around disagreements and controversies can enable more inclusive, empowered academic co
We study two-dimensional, stationary square and hexagonal patterns in the thermocapillary deformational thin-film model for the fluid height h [Formula presented] that can be formally derived from the Bénard–Marangoni problem via a long-wave approximation. Using a linear stability analysis, we show that the flat surface profile corresponding to the pure conduction state destabilises at a critical
In this paper, we present a new generic Structure-From-Motion pipeline, GenSfM, that uses a non-parametric camera projection model. The model is self-calibrated during the reconstruction process and can fit a wide variety of cameras, ranging from simple low-distortion pinhole cameras to more extreme optical systems such as fisheye or catadioptric cameras. The key component in our framework is an a
Allergic contact dermatitis (ACD) is a prevalent inflammatory skin condition triggered by allergens such as 2-methyl-4-isothiazolin-3-one (MI), a common preservative. The incidence of contact allergy to MI has fallen in Europe in recent years, attributable to government regulation limiting concentrations of MI I; however, incidence continues to rise in the USA. The pattern and extent of distributi
Den femte mars i år kom det in en begäran om återlämnande till Historiska museet vid Lunds universitet. Begäran kom in från privatpersoner bördiga från Luleå samt Lule-Boden Sameförening och berör kranier efter två samiska individer.
The electricity market exhibits significant uncertainty arising from rapid fluctuations in prices, variations in load demand, and the intermittent nature of renewable energy resources. Effectively managing residential energy under these dynamic conditions is a challenging task. Demand Response (DR) offers a practical solution by enabling the flexible scheduling of energy consumption in response to
Given ongoing debates about the nature and consequences of religious belief, effective procedures for experimentally controlling such beliefs are highly desirable. To date, however, there are few robust, replicable methods. Here, we show that the “choice blindness” paradigm can be leveraged to directly manipulate religious beliefs and attitudes in a way that avoids demand characteristics. Across t
