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Introduction: Synovial fibroblasts (S-Fib) are recognized as key drivers of joint inflammation in adult arthritis. Moreover, data are limited on the processes driving monocyte activation in oligoarticular juvenile idiopathic arthritis (oJIA). Therefore, we aimed to explore if S-Fib from patients with oJIA induce monocyte activation. Methods: S-Fib were isolated from the synovial fluid (SF) of n =

In recent years, Predictive Digital Twins (PDT) have emerged as a potential tool to monitor and predict the behavior of dynamic systems, including nature-based solutions in natural coastal systems. Here, we test the potential of using a simple, coupled shoreline and beach-dune model as a base for a PDT. The models exchange sediment flux balance information at each time step and recalculate shoreli

OBJECTIVE: To assess structural changes at peripheral entheses and the association with spinal bone formation in patients with long-standing radiographic axial spondyloarthritis (r-axSpA) overall and stratified by sex. METHODS: Peripheral entheses were examined cross-sectionally using ultrasound (US) in patients fulfilling the modified New York criteria for ankylosing spondylitis (AS) and assessed

In the present study, the novel family genetic risk score (FGRS) method, a reliable quantification of latent genetic risk, was applied to posttraumatic stress disorder (PTSD) to examine associations between genetic liability and clinical features of PTSD among 3,097,180 individuals in the Swedish national registries. FGRS was calculated based on lifetime PTSD status for first- through fifth-degree

We present a genome assembly from a male specimen of Zethes insularis (Arthropoda; Insecta; Lepidoptera; Erebidae). The assembly contains two haplotypes with total lengths of 862.07 megabases and 869.20 megabases. Most of haplotype 1 (99.0%) is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. Most of haplotype 2 (95.76%) is scaffolded into 31 chromosomal pseudomolecu

Engineering risk assessment has traditionally focused on direct impacts to individual assets or systems. However, as society's most notable risks increasingly stem from complex, interdependent systems, conventional methods fail to capture the cascading consequences and deepening uncertainty. Addressing this gap requires developing or extending assessment methods. To guide such development and alig

Wildfires, insect outbreaks, and storms cause large pulses of tree mortality. Climate change amplifies these forest disturbances, yet their future magnitude and extent remain uncertain. Here, we simulated future forest disturbance regimes at 100-meter resolution across Europe using a deep learning–based simulation framework. Our results show that forest disturbances will continue to increase throu

Democracies face a crisis of public reason grounded in a disintegration of shared epistemic ground and amplified by digital polarisation and AI-mediated disinformation. Current pedagogy, focused on deconstructive critique or fact-checking skills, fails to address how algorithmic systems engineer plausibility at scale. Higher education must cultivate discerning judgement alongside critique. Drawing

Background: This is one of the few European studies of self-management and self-monitoring during the initial two weeks following discharge after open cardiac surgery. Typical outcomes are mortality, morbidity, surgical complications and additional medical treatment. Equally important for enabling person-centred care are the patients’ perspective and main concerns. The aim was to explore feasibili

Conventional social mobility research misses substantial inequalities of opportunity. To capture intergenerational persistence of family social status, we need to move beyond parent-child associations in occupation or income. We study the inheritance of surname status as a group-level process, using full-count population data for Swedish men between 1880 and 2015 and surname types reflecting prein

The purposes of this article-based thesis are to explore and understand preaching as a practice in general, and the practice of preaching in digital culture and spaces in particular. Informed by the practice theory of Theodore Schatzki, it presents the results of a cross-case analysis of four different case studies of the practice of preaching in digital culture and spaces in Swedish protestant chThe purposes of this article-based thesis are to explore and understand preaching as a practice in general, and the practice of preaching in digital culture and spaces in particular. Informed by the practice theory of Theodore Schatzki, it presents the results of a cross-case analysis of four different case studiesof the practice of preaching in digital culture and spaces in Swedish protestant chu

This pioneering volume explores complex local, global and digital contexts from the perspectives of Digital Theology.The use of and access to digital technology is highly contextual. It differs between regions, generations, classes, religious denominations, and gender. Which problems theologians claim to be important and which developments they ignore is contingent on their cultural, social, econo

The aim of this special issue is to advance research on biblical reception in Scandinavian contexts and to offer new insights into the intricate relationship between religiosity and secularity more broadly. This is done by engaging with theoretical questions concerning religion, secularity, and biblical reception in the modern world. In this introduction, we contextualize the special issue in relaThe aim of this special issue is to advance research on biblical reception in Scandinavian contexts and to offer new insights into the intricate relationship between religiosity and secularity more broadly. This is done by engaging with theoretical questions concerning religion, secularity, and biblical reception in the modern world. In this introduction, we contextualize the special issue in rela