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Researchers at MultiPark have uncovered in mice how the protein TDP-43, known for its role in several neurodegenerative diseases, disrupts the hypothalamus, the brain’s key center for metabolic control. Their study sheds new light on the role of TDP-43 in metabolic and psychiatric symptoms shared across frontotemporal dementia, Huntington’s disease, and ALS – findings that could support the develo
An experimental study from Lund University reveals for the first time that different Parkinson’s medications affect brain activity in distinct ways. This could explain why some patients develop impulsive and compulsive behaviors as a result of their treatment. The findings have been published in NPJ Parkinson’s Disease. Upon receiving treatment for their motor symptoms, many patients with Parkinso
https://www.multipark.lu.se/article/brain-activation-pattern-behind-impulsivity-parkinsons-treatment-discovered - 2026-05-09
Meet our scientist, Dr. Niklas Mattsson-Carlgren! He explains why studying biomarkers is essential to advancing Alzheimer’s research. Niklas Mattsson-Carlgren is part of the Clinical Memory Research group, a leading centre in the development and evaluation of novel biomarkers for Alzheimer’s disease. In this podcast episode, he discusses why biomarker research is key not only to detecting but also
With over 15 research groups dedicated to Alzheimer’s disease research, MultiPark’s goal is to understand the origins of the disease, develop early diagnostics, and improve treatments. The multidisciplinary approach sheds light on the disease from several angles, bridging basic research with clinical investigations. Here are five projects. September is World Alzheimer’s Month. Globally, around 40
For decades, large stretches of human DNA were dismissed as ‘junk’ and considered to serve no real purpose. In a new study in Cell Genomics, researchers at Lund University in Sweden show that the repetitive part of the human genome plays an active role during early brain development and may also be relevant for understanding brain diseases. DNA carries the complete set of instructions an organism
https://www.multipark.lu.se/article/why-repetitive-dna-matters-human-brain-evolution-and-disease - 2026-05-09
Enormous amounts of data about Alzheimer’s Disease have been generated from clinical studies so far. Still, the molecular drivers of Alzheimer’s Disease are largely unknown. With the TAU-TIME project, Jacob Vogel aims to advance knowledge by developing an AI tool that brings together known biological mechanisms with data from patients with the disease. Recent funding from the European Research Cou
https://www.multipark.lu.se/article/time-unite-lab-and-clinic-15-million-eu-build-ai-model-alzheimers-disease - 2026-05-09
Early diagnosis is key to receiving proper care and advancing research on future therapies for neurodegenerative diseases such as Parkinson’s and dementia with Lewy bodies. New research from Skåne University Hospital and Lund University shows that combining a simple smell test with advanced spinal fluid analysis can predict these diseases with high accuracy, while sparing nearly half of patients f
https://www.multipark.lu.se/article/smell-test-cuts-need-invasive-parkinsons-screening - 2026-05-09
Researchers at Lund University in Sweden have developed a digital cognitive test for diagnosing Alzheimer's disease that is intended for use in primary care. “This digital test, which patients perform on their own with minimal involvement from healthcare personnel, improves the primary care physician's ability to determine who should be further examined by blood tests for Alzheimer's pathology ear
https://www.multipark.lu.se/article/new-digital-cognitive-test-diagnosing-alzheimers-disease - 2026-05-09
What if brain diseases could be cured by turning on the proper genes? Meet our scientist, Professor Cecilia Lundberg! She explains how gene therapy may complement cell therapies to combat Parkinson’s disease. Cecilia Lundberg is head of the CNS Gene Therapy Research Group and has spent her whole career developing cutting-edge tools that may be used in future therapies to slow down or cure neurodeg
https://www.multipark.lu.se/article/meet-our-scientists-podcast-cecilia-lundberg-about-gene-workshop - 2026-05-09
Have you ever wondered what the journey of someone living with Parkinson’s disease looks like? Meet our scientist, Professor Per Odin! He shares his experiences of the bumpy road faced by patients he has supported over the years, both in healthcare and in research studies. Parkinson’s disease is a long, challenging course; one that science works tirelessly to understand, where halting neurodegener
https://www.multipark.lu.se/article/meet-our-scientists-podcast-odin-about-parkinsons-journey - 2026-05-09
In a study led by Lund University and the Amsterdam University Medical Center, researchers used PET to analyse aggregates of tau pathology in more than 12,000 people from all over the world. The study – the largest ever of its kind – examines the connection between genetic predisposition, gender and age in relation to tau pathology in Alzheimer’s disease. The study is published in Nature Neuroscie
https://www.multipark.lu.se/article/largest-ever-taupet-study-alzheimers-deepens-understanding-disease - 2026-05-09
With an approval rate of just 17 %, this year’s Swedish Research Council grants were harder than usual to secure. Still, several of MultiPark’s group leaders were awarded major grants in Medicine and Health 2025. Receiving grants from the Swedish Research Council is seen as a mark of quality and an important step in advancing an independent research group. Recently, six MultiPark researchers were
https://www.multipark.lu.se/article/multipark-scientists-awarded-prestigious-vr-consolidator-grant - 2026-05-09
Nine researchers from MultiPark have been listed as Highly Cited Researchers by Clarivate, highlighting their significant global research impact. Clarivate acknowledges researchers whose publications rank among the top 1% most cited in their fields over the past eleven years. The selected scientists have published several highly-cited papers. Congratulations to Oskar Hansson, Shorena Janelidze, Sa
https://www.multipark.lu.se/article/multipark-researchers-recognized-clarivates-highly-cited-list - 2026-05-09
Recently, MultiPark opened its doors to the local Parkinson’s Association, who were invited behind the scenes to see how research on their condition is conducted. Here are some of the laboratories that were visited. Today’s basic research on brain disorders such as Parkinson’s may be the starting point for tomorrow’s treatments. This may explain the participants’ deep interest in MultiPark’s exper
https://www.multipark.lu.se/article/journey-discovery-research-multipark-opens-labs-parkinsons-association - 2026-05-09
The Promobilia Foundation is investing SEK 25 million in a new large-scale research project targeting Parkinson’s disease. The donation enables four research groups—one at Lund University and three at Karolinska Institutet—to join forces in developing new treatment strategies that address the root causes of the disease. Using innovative approaches, including advanced gene therapies and targeted ve
Almost half of all dementia cases may be associated with modifiable factors such as smoking and high blood pressure. At the same time, some risk factors are built into our biology, such as age, sex, and genetics. But dementia is not a single disease, rather symptom of multiple underlying disorders. Therefore, risk factor profiles for various dementia subtypes are likely to vary. A new study highli
https://www.multipark.lu.se/article/how-lifestyle-and-biology-shape-brain-changes-linked-dementia - 2026-05-09
Turning scientific knowledge into solutions that improve people’s lives is the ultimate goal of research. But the path from novel scientific data to an innovation that may impact health care is long; many promising ideas never get a fair chance. For 16 years, MultiPark Innovation has supported researchers in their first efforts in transforming discoveries into inventions that may benefit patients
https://www.multipark.lu.se/article/multipark-innovation-grants-have-generated-inventions-2011 - 2026-05-09
Modern technology is helping our researchers to get a sneak peek into the brain – and now the winning image has been chosen in MultiPark’s photo competition #Neurovision. All entries will be on display for the public at MultiPark Café’s exhibition – come and explore the secrets of the brain with us on 3 March! MultiPark is a strategic research area at Lund University, where interdisciplinary resea
https://www.multipark.lu.se/article/multiparks-vernissage-neurovision-celebrating-winners-our-photo-competitions - 2026-05-09
New blood tests for diagnosing Alzheimer’s disease are making early diagnosis increasingly feasible. However, the fact that the markers being measured change long before any symptoms develop represents a challenge. Research led by Lund University in Sweden shows that a previously unused blood marker, when combined with those markers already in use, can significantly reduce the risk of misleading d
https://www.multipark.lu.se/article/new-blood-marker-reduces-risk-false-diagnosis-alzheimers-disease - 2026-05-09
The symptom profiles of different neurodegenerative diseases often overlap, and diagnosing age-related cognitive symptoms is complex. A patient may have multiple overlapping disease processes in the brain at the same time. Now, researchers at Lund University have developed an AI model showing that it is possible to detect several neurodegenerative diseases from a single blood sample. The study is
https://www.multipark.lu.se/article/new-ai-model-can-detect-multiple-cognitive-brain-diseases-single-blood-sample - 2026-05-09
