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Solid tumors are composed of cancer cells, as well as resident or infiltrating non-malignant cells that contribute to the malignant state in an ecosystem generally accepted as the tumor microenvironment. Microenvironmental tumor hypoxia is the foremost leading cause of angiogenesis, i.e. the formation of new blood vessels from pre-existing vasculature, and its correlation to tumor growth and aggre
An integrated millimeter-wave wavelet transmitter has been fabricated and characterized. It consists of a generator core on a co-designed compact monolithically-integrated antenna. The peak output equivalent isotropic radiated power has been measured to 11 dBm, in 80, 160, and 320 ps wavelets centred at 63.5 GHz. This corresponds to a power of 5 dBm radiated from the 6 dBi antenna. At a dc-supply
Background and purpose Few economic or quality-of-life studies have investigated the long-term consequences of fragility fractures. This prospective observational data collection study assessed the cost and quality of life related to hip, vertebral, and wrist fracture 13-18 months after the fracture, based on 684 patients surviving 18 months after fracture. Patients and methods Data regarding reso
CdTe semiconductor nanocrystals were synthesized with three different stabilizers: Mercaptoacetic Acid (MM), Mercaptopropionic Acid (MPA) and 2-Mercaptoethanol (ME) at pH approximate to 11.2 by wet chemical route using potassium tellurite and cadmium chloride as starting materials. The effect of capping agent on the preparation of these samples was evaluated using UV-Visible absorption and photolu
Objectives: To investigate whether low self-rated health (SRH) is associated with increased mortality in individuals with diabetes. Design: Population-based prospective cohort study. Setting: Enrolment took place between 1992 and 2000 in four centres (Bilthoven, Heidelberg, Potsdam, Umea) in a subcohort nested in the European Prospective Investigation into Cancer and Nutrition. Participants: 3257
The alleged efficacy of pharmaceutical industry self-regulation has been used to repudiate increased government oversight over promotional activity. European politicians and industry have cited Sweden as an excellent example of self-regulation based on an ethical code. This paper considers antidepressant advertising in Sweden to uncover the strengths and weaknesses of self-regulation.
Tamoxifen is associated with a reduced risk of coronary heart disease (CHD). However, there are few reports on long-term effects. Using data from a large Swedish randomized trial of 5 and 2 years of adjuvant tamoxifen in women with early breast cancer, we here present results on morbidity and mortality from cardiac diseases during treatment and long-term after treatment. A total of 4,150 patients
An active polyphase filter capable of high frequency quadrature signal generation has been analyzed. The resistors of the classical passive polyphase filter have been replaced by transconductors, CMOS inverters [1,2]. A three-stage 0.13 um CMOS active polyphase filter has been designed. Simulations with a differential input signal show a quadrature error less than 1◦ for the full stable input volt
The geometric and electronic structure of condensed phase organic conducting polymer PEDOT:PSS blends has been investigated by periodic density functional theory (DFT) calculations with a generalized-gradient approximation (GGA) functional, and a plane wave basis set. The influence of the degree of doping of the PEDOT polymer on structural and optical parameters such as the reflectivity, absorbanc
Dalteparin, a low molecular weight heparin (LMWH), is given to pregnant women with thrombotic disorders. Clinical observations together with the documented changes of heparan sulfate proteoglycans in normal and protracted labor fostered the idea that LMWH shortens delivery time. Labor time was retrospectively determined among nulliparous pregnant women treated with dalteparin because of previous v
The bluethroat Luscinia svecica is a particularly interesting species for the study of the mechanisms that control migration because it comprises several recently diverged subspecies that differ in migratory distance and direction. Here we use ringing data to describe the migration strategy and winter distribution of L. s. cyanecula and L. s. namnetum along the eastern Atlantic coast of Iberia and
Popular Abstract in Swedish Fallolyckor hos äldre -en tyst epidemi Fallolyckor hos äldre är idag ett omfattande men underrapporterat hälsoproblem. Cirka 1,600 individer, en huvuddel äldre, avlider årligen i Sverige till följd av ett fall. Detta kan jämföras med 1,400 respektive 2,400 individer som avlider årligen av bröst- och prostatacancer. Strax under 300 individer dör årligen i trafiken i SveIn a ‘greying world’ with aging populations, falls in the elderly are a challenge to the health care system as they are associated with substantial mortality and morbidity. Apart from physical injuries, the consequences of falls are broad, with additional psychological and social consequences. The overall objective of this dissertation was to study falls and related risk factors, predictors, and c
Objective - To examine whether there were any differences in the recovery in performance of personal activities of daily living (P-ADL) in elderly persons in relation to cognitive impairments pre- and post-stroke from discharge to 6 and 12 months in elderly persons. Methods - Forty-five elderly persons after stroke were assessed at discharge from hospital and at 6 and at 12 months after stroke ons
To identify markers of non-response to neoadjuvant chemotherapy (NAC) that could be used in the adjuvant setting. Sixteen pathologists of the European Working Group for Breast Screening Pathology reviewed the core biopsies of breast cancers treated with NAC and recorded the clinico-pathological findings (histological type and grade; estrogen, progesterone receptors, and HER2 status; Ki67; mitotic
Numerous different bioreactor systems are applied for hydrogen production by dark fermentation. Thermophilic fermentations are gaining an increased interest due to the high hydrogen yields associated with them. In order to reach the best thermophilic fermentation system, 2 types of bioreactors, a trickling bed and a fluidized bed system, were constructed and operated under similar conditions. Both
The purpose of this work was to evaluate three motion-monitoring systems: Sentinel (TM), Catalyst (TM) (both C-RAD) and Real-time Position Management (RPM (TM)) system (Varian Medical Systems Inc) for respiratory gating in radiotherapy. To measure the systems. latency, an in-house built circuit with a microcontroller operating a piston was used. The trigger pulse was sent from the gating systems t
The expression of cell surface glycans terminating with sialic acid (SA) residues has been found to correlate with various disease states there among cancer. We here report a novel strategy for specific fluorescence labeling of such motifs. This is based on sialic acid-imprinted core shell nanopartides equipped with nitrobenzoxadiazole (NBD) fluorescent reporter groups allowing environmentally sen
Positron emission tomography combined with computed tomography (PET/CT) is a quantitative technique used for diagnosing various diseases and for monitoring treatment response for different types of tumours. However, the accuracy of the data is limited by the spatial resolution of the system. In addition, the so-called partial volume effect (PVE) causes a blurring of image structures, which in turn
Objective. The first changes in the diabetic kidney are glycogen deposits in the epithelial cells of the thick ascending limb of Henle, which leads to decreased production of Tamm-Horsfall protein (THP). The production of THP is also influenced by nitric oxide (NO). The aims of this study were to investigate whether low excretion of THP, a sign of distal tubular dysfunction, in patients with type
