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Aims: Stratifying renal damage in type 2 diabetes is challenging due to overlapping features between diabetic nephropathy (DN) and non-diabetic renal disease (NDRD). While miR-27b-3p modulates kidney fibrosis in DN through the lysine63 ubiquitination pathway, its upstream regulation and diagnostic relevance remain unclear. Methods: In a biopsy-verified cohort of 231 chronic kidney disease (CKD) pa
Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated the function of laminin γ1 chain in heart, lung and other tissues by generating a mouse that lacks laminin γ1 in cells expressing SM22α (Tagln) (LMγ1 flox/SM22α C
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
Background: Signet ring cell (SRC) colorectal cancer is strongly associated with peritoneal metastases (PM), but the role of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains uncertain due to poor prognosis. This study aimed to analyse the prognostic impact of SRCs, assess clinical characteristics, and evaluate the risk of open-close laparotomy. Methods: Thi
Aims: Experimental evidence suggests an important role for sphingosine-1-phosphate (S1P) and its generating enzymes sphingosine kinase 1/2 (SphK1/2) in obesity. We and others have shown that plasma S1P levels are elevated in obese mice and humans. Preclinical studies suggest that genetic SphK2 ablation in mice protects from age- and diet-induced obesity and metabolic dysfunction. We aimed at inves
This article explores class precarity among male heavy industrial shopfloor workers in northern Vietnam. It brings Vietnamese understandings of crisis into a dialogue with the anthropology of crisis, arguing a crisis framework offers a helpful analytical entry to exploring gendered class precarity. Striving to provide quality healthcare and education for their children in Vietnam's 'socialist-orie
Global capital is increasingly settling in Vietnam’s ‘socialist-oriented market economy’. Those employed in the outsourced workplace may encounter precarious and insecure working conditions, while women employees may even be subjected to gender-based violence. Drawing on ethnographic data collected in the Industrial Zones of northern Vietnam, this article examines gendered workplace violence and t
Background Although genetic variants associated with bladder cancer (BCa) risk have been identified through hypothesis-driven and genome-wide association studies, a systematic understanding of BCa genetic susceptibility at the gene and pathway levels remains to be achieved. Materials and methods In this 2-stage functional genomics study, we used 5 independent tools for genome-wide gene mapping and
Background: The coronavirus disease-2019 (COVID-19) pandemic posed pronounced challenges in the care of lung transplant (LTx) recipients. Global variations in containment strategies and the introduction of messenger ribonucleic acid (mRNA) vaccines have sparked extensive debate in both scientific and public arenas. Methods: This retrospective study compared outcomes among LTx recipients in Denmark
Biotechnology is a rapidly progressive field, currently transforming agriculture, healthcare, and life sciences. This rapid development comes with serious legal and ethical challenges as well as risks for human security and health. NATO has prioritized biotechnology and human enhancement technologies for defense, focusing on legitimate, defensive applications. This paper highlights four clusters o
Purpose: To analyse risk of osteoporotic fractures in foreign-born individuals migrating to Sweden at different ages, compared to Swedish-born individuals. Methods: This was a nationwide open cohort study including individuals ≥30 years of age at baseline (N = 4,715,081). Foreign-born individuals were divided as having arrived to and being registered in Sweden from the ages 0–30 years of age or >3
The Routledge International Handbook of Research Security examines research security – the act of protecting and securing university research and teaching in the name of national security – through a multi-disciplinary and comparative lens.
The invasive oomycete pathogen Aphanomyces astaci significantly threatens native European crayfish populations, prompting investigations towards the effects of protective immunostimulation on the immune response of the vulnerable noble crayfish (Astacus astacus). Here, we evaluate the effect of three oomycete-derived immunostimulant treatments: laminarin (β-1,3-glucan found within the Ap. astaci c
Globalization and commodification trends in football negatively impact the climate in terms of greenhouse gas emissions from leagues and international tournaments. A significant share of these emissions stem from the flying of teams, staff and fans. Using Norway as a case study, we ask what a national football federation is doing and could be doing to reduce its ecological footprint from air trave
