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Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M protein. Here, we engineer the IgG2-4 subclasses of Ab25. Despite having reduced binding, the IgG3 version promotes stronger phagocytosis of bacteria. Using atomic

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst

https://www.medarbetarwebben.lu.se/sites/medarbetarwebben.lu.se/files/2024-11/Kvalitetspolicy%20fo%CC%88r%20Lunds%20universitet.pdf - 2026-04-29

This project is a collaboration between Lund University Historical Museum, Lund University Library and various departments of the university. The team members represent the fields of history, archaeology, Latin language studies, anthropology, museology, geology, botany and zoology. This combined expertise is necessary to tackle the diverse material and questions posed in the project. Per Karsten,

https://www.historiskamuseet.lu.se/stobaeus-project/stobaeus-project/research-team - 2026-04-27

A shift in new venture creation can be observed from purely profit-oriented models to alternatives attempting to also answer social and environmental needs. Because of their nature, these alternatives face issues regarding their integration in traditional financial and business spheres. Shared Value Creation is a framework that attempts to analyse these ventures and those challenges. Blockchain te