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The transition from fossil jet fuel to biojet fuel is an important step towards reducing greenhouse gas (GHG) emissions from aviation. To enable such a fuel shift, the Swedish Government introduced a GHG emission reduction mandate of 27% by 2030 for aviation fuel sold in Sweden, forcing fuel suppliers to blend in biojet fuel in fossil jet fuel. A similar policy instrument is being discussed within
Background & Aims: In 2014, the burden of hepatitis C virus (HCV) in Sweden was evaluated, to establish a baseline and inform public health interventions. Considering the changing landscape of HCV treatment, prevention, and care, and in light of the COVID-19 pandemic, this analysis seeks to evaluate Sweden's progress towards the World Health Organization (WHO) elimination targets and identify
Introduction: Haemophilia A care has changed with the introduction of emicizumab. Experience on the youngest children is still scarce and clinical practice varies between haemophilia treatment centres. Aim: We aimed to assess the current clinical practice on emicizumab prophylaxis within PedNet, a collaborative research platform for paediatricians treating children with haemophilia. Methods: An el
Introduction The provision of healthcare for patients with inflammatory arthritis occurs in the context of somewhat conflicting targets, values and drivers. Therefore, there is a need for introducing 'value-based healthcare' defined as the value of patient relevant health outcomes in relation to costs. This term is a central part of tomorrow's healthcare sector, especially for rheumatic diseases,
The cardiovascular regulation in humans depends to a major extent on sympathetic reflexes originating from volume receptors in the arterial as well as the cardiopulmonary region. With experimental approaches, such as lower body negative pressure (LBNP) and tilting, signs of reduced efficiency with ageing have been shown. However, a confounding factor may be an age-related decline in venous capacit
Background: The prevalence of risk factors for ischemic stroke may vary between different groups of stroke patients. We examined the distribution of individual well-established risk factors as well as the multiplicity of risk factors in different age groups and among subtypes. Methods: In the Lund Stroke Register, we consecutively enrolled 2,505 patients with first-ever ischemic stroke from 2001 t
This study was performed to investigate the impact of acute hyperglycemia (HG) on the permeability of the normal glomerular filtration barrier in vivo. In anaesthetized Wistar rats (250-280g), the left ureter was catheterized for urine collection, while simultaneously blood access was achieved. Rats received an intravenous (i.v.) infusion of either 1) hypertonic glucose to maintain blood glucose a
Introduction: Falls among hospitalized older adults increase morbidity, prolong hospital stays, and raise healthcare costs. Sensor-based technologies and medical devices are emerging tools for fall prevention, but their clinical effectiveness remains uncertain. This systematic review aimed to assess their effectiveness in reducing inpatient falls, staff workload, and physical restraint use in hosp
Background: Stroke and reduced survival are devastating complications of atrial fibrillation (AF). Biomarker-based ABC-AF risk scores improve risk prediction in AF, and risk-guided treatment recommendations may improve patient outcomes. Design: The ABC-AF study is a national, multicenter, prospective, registry-based, randomized controlled, parallel-group, open-label study. Its primary objective is
Peatlands have become a silver bullet in climate mitigation policy globally. Restoring and rewetting agricultural peatlands is key for meeting reduction targets within the agricultural sector. But unlike other sectors, change rests on the decisions of individual farmers. In Denmark, a political aim towards restoring 100.000 hectares of agricultural peatlands by 2030 is challenged by uncertainty, d
Introduction: To increase the sustainability of healthcare, clinical trials must assess the environmental impact of interventions alongside clinical outcomes. This should be guided by Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) and Consolidated Standards of Reporting Trials (CONSORT) extensions, which will be developed by The Implementing Climate and Environmental O
Occupational exposure to the carcinogen hexavalent chromium [Cr(VI)] occurs during stainless steel production, welding, and chrome plating. Two sister-projects, SafeChrom and SAM-Krom, were initiated in Sweden and Denmark, respectively, to inform stakeholders, decision-makers and regulators on current occupational exposure to Cr(VI), and preventive measures prior to revision of national occupation
Climate change is intensifying short-duration rainfall extremes, increasing urban pluvial flood risk across Swedish municipalities. This study develops a novel spatial statistical framework for basement flood risk assessment using Log-Gaussian Cox Process (LGCP) models on metric graphs, applied to 17 years of flood records from Trelleborg, southern Sweden.Unlike conventional approaches that treat
Objectives To identify and describe frameworks for systematically identifying research gaps from evidence syntheses, framing research needs, and establishing priorities, with emphasis on their use of GRADE (Grading of Recommendations Assessment, Development and Evaluation) certainty of evidence (CoE) domains and evidence-to-decision (EtD) criteria. Study Design and Setting We conducted a scoping r
Background Increased airflow is reported as helpful in reducing the sensation of breathlessness. This systematic review aimed to assess the effectiveness of airflow on breathlessness (primary outcome, measured using a validated tool at rest or during exercise) and health-related quality of life (secondary outcome) in people with serious respiratory illness. Methods We searched Ovid MEDLINE, Embase
In pulmonary arterial hypertension (PAH), increased pulmonary vascular resistance (PVR) causes right ventricular pressure overload and left ventricular (LV) underfilling. We investigated LV mechanics and their prognostic value in PAH using cardiovascular magnetic resonance (CMR)-derived LV pressure-volume (PV) loops. We included 96 patients (median age 64 years, 70% women) with PAH and clinically
Early experiences with robotic-assisted esophagectomy showed disappointing anastomotic outcomes when techniques were directly translated from open or thoracoscopic surgery. Among intrathoracic anastomotic options in robot-assisted Ivor Lewis esophagectomy (RAMIE-IL), emerging data suggest lower complication rates with the linear stapled side-to-side technique. This method was adopted at our instit
