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Summary: In this population-based study, we compared the incidence of distal radius fracture in 2016 with that in the same region’s adult general population in 2001 using radiographs to identify fracture cases. We showed that the incidence decreased by 24% in 2016 compared with 2001 indicating an important development. Introduction: We conducted an epidemiological study on residents of northeaster
This Phase I study investigated the recommended Phase II dose (RP2D) of inotuzumab ozogamicin (InO), a CD22-directed antibody-drug conjugate, in pediatric patients with multiple-relapsed/refractory (R/R) CD22-positive acute lymphoblastic leukemia (ALL). Patients (≥1-<18 years) received three InO doses (Days 1, 8, 15) per course. Dose-escalation was based on dose-limiting toxicities (DLT) during Co
Land use change threatens global biodiversity and compromises ecosystem functions, including pollination and food production. Reduced taxonomic α-diversity is often reported under land use change, yet the impacts could be different at larger spatial scales (i.e., γ-diversity), either due to reduced β-diversity amplifying diversity loss or increased β-diversity dampening diversity loss. Additionall
Water scarcity is a growing global challenge, with projections indicating that 40% of the world’s population could face shortages by 2030. At the same time, the transition to renewable energy is essential for reducing carbon emissions, with solar power playing a key role. The DESOLINATION project addresses these challenges by integrating concentrated solar power with advanced membrane processes fo
Background Monitoring labor and childbirth, early recognition, and treatment of complications are critical for preventing adverse birth outcomes. However excessive use of interventions during labor has not been demonstrated to enhance subsequent birth outcomes and may, in fact, pose a risk of harm. The World Health Organization has recently synthesized research from the last decade concerning labo
Brazil’s electricity system remains profoundly shaped by its historical reliance on hydropower, which has repeatedly exposed the country to crises during periods of drought. This thesis examines the water–energy nexus in Brazil from a temporal perspective, showing how past legacies, present vulnerabilities, and future pathways are interconnected. A review of the literature reveals that nexus studi
The main purpose of this project has been to examine the accessibility of refereed conference articles and the OAand publishing policies of conferences in order to in this way elucidate different aspects concerning self-archiving in Swedish institutional repositories. For this purpose, the project participants have examined a number of conferences and references to conference articles via their in
Objective Arterial pulse contour analysis is gaining widespread acceptance as a monitor of continuous cardiac output (CO). While this type of CO measurement is thought to provide acceptable continuous measurements, only a few studies have tested its accuracy and repeatability under unstable hemodynamic conditions. We compared continuous CO measurement using the pulse contour method (PCCO) before a
The European Union (EU) has laid down very clear objectives for the reduction of greenhouse gases in the hope that it will prevent or mitigate climate change. Political incentives are used to make the power industry adopt changes in order to reach these EU targets. In this thesis, some solutions that could help power companies meet the EU objectives are evaluated. Thermodynamic models have been de
The pandemic of chronic non-communicable diseases (NCDs) poses substantial challenges to the health financing sustainability in high-income and low/middle income countries (LMICs). The aim of this review is to identify the bottle neck inefficiencies in NCDs attributable spending and propose sustainable health financing solutions. The World Health Organization (WHO) introduced the "best buy" concep
1. The postnatal development of nociceptive withdrawal reflexes was studied. In awake intact rats, forelimb, hindlimb and tail reflexes were recorded on videotape. In decerebrate spinal rats, electromyography (EMG) was used to record nociceptive withdrawal reflexes in musculi extensor digitorum longus (EDL), peronei, gastrocnemius-soleus (G-S) and biceps posterior-semitendinosus (BP-ST). Thermal (
Background: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. Methods: Sixty healthy subjects 25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m(2)) were included in a cross-over study with 5 hours of
INTRODUCTION: Improving access to genetic testing has increased the number of individuals identified with cancer genetic predisposition. Hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) are key examples of high-risk hereditary cancer syndromes. Ensuring that carriers of germline pathogenic/likely pathogenic variants (GPVs) receive evidence-based risk counseling, surveillance and
Over the past decade, circular strategies have been gaining momentum in the construction sector in an effort to reduce resource consumption, waste generation and environmental impacts. This transition requires not only changes in the construction process but also transformations in the constellation of actors involved. Previous research has mapped actors in circular construction and emphasised the
The COVID-19 pandemic led to substantial changes in working conditions in academia. This study aimed to explore how academics’ perceptions of job demands,resources and occupational well-being have changed since the COVID-19 pandemic, as well as their expectations and concerns regarding future working practices. To achieve this aim, we conducted a qualitative follow-up study with 16academics who pa
Background Subcutaneous emicizumab prophylaxis is increasingly used for early prophylaxis in infants with severe hemophilia A (SHA). Although the HAVEN 7 trial (NCT04431726) reported on 55 infants with SHA, real-world information regarding factor (F)VIII exposure, inhibitor development, and bleeding on this age group remains limited. Objectives To describe FVIII exposure, model-based annualized bl
The global cobalt cycle in society was modelled using an integrated systems dynamics model, WORLD6, integrating several earlier system dynamics models developed by the authors. The COBALT sub-model was used to assess the long-term sufficiency of the available extractable cobalt and address the effect of different degrees of recycling on cobalt supply. The extraction of cobalt is mostly dependent o
AI-enabled technologies are developing rapidly, but the first wave of the Digit Employers’ Digital Practices at Work Survey (2021-22) showed that their use by firms is not yet widespread. This Data Commentary presents findings from the second wave of the Survey, conducted during 2023, based on responses from 1,150 firms.The findings show that adoption of AI-enabled technologies by UK firms remains
