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Background: There has been an increasing number of single-centre studies describing the long-term outcomes of patients with Hirschsprung disease. This study aimed to systematically review the literature on long-term bowel, urological, and sexual functional outcomes, fertility and quality of life in adults with Hirschsprung disease. Methods: A PROSPERO-registered systematic review of the English li
Context. AU Mic is a very active M dwarf star with an edge-on debris disk and two known transiting sub-Neptunes with a possible third planetary companion. The two transiting planets exhibit significant transit-timing variations (TTVs) that are caused by the gravi tational interaction between the bodies in the system. Aims. Using photometrical observations taken with the CHaracterizing ExOPlanet Sa
Purpose The EPHOR-NIGHT cohort was established to investigate how night shift work influences biological pathways and chronic disease risk using a comprehensive working-life exposome approach, focusing on cardiometabolic, mental health, cognitive and biological ageing outcomes. Participant The cohort includes 937 workers aged 20–65 years (88%female), primarily from the healthcare sector (96%) in S
Background: Numerous gene loci are related to single measures of body weight and shape. We investigated if 55 SNPs previously associated with BMI or waist measures, modify the effects of fat intake on weight loss and waist reduction under energy restriction. Methods and Findings: Randomized controlled trial of 771 obese adults. (Registration: ISRCTN25867281.) One SNP was selected for replication i
Members of the myocardin family bind to the transcription factor serum response factor (SRF) and act as coactivators controlling genes of relevance for myogenic differentiation and motile function. Binding of SRF to DNA is mediated by genetic elements called CArG boxes, found often but not exclusively in muscle and growth controlling genes. Studies aimed at defining the full spectrum of these CArG
To find the optimal by-pass road alignment in the Tlokweng Planning Area in Botswana, a multi-criteria spatial-based model is developed using the GIS-MCE approach. In respect to the environmental impact assessment (EIA) approach, in this research a set of criteria is classified under 3 themes – economic, environmental and social. To determine the criterion and theme weights and perform their aggre
Background: Explicit weight bias is known as negative attitudes and beliefs toward individuals due to their weight status and can be perpetuated through misconceptions about the causes of obesity. Individuals may also experience weight bias internalization (WBI) when they internalize negative weight-related attitudes and self-stigmatize. There is a paucity of research on the beliefs about the caus
Introduction: Despite being implicated in a wide spectrum of community- and healthcare-acquired infections, anaerobes have not yet been incorporated into systematic surveillance programs in Europe. Methods: We conducted a multicentre retrospective observational study analysing all anaerobic strains isolated from blood cultures in 44 European Hospital Centres over a 4-y period (2020–2023). Diagnost
Biological diversity faces a global crisis with increasing extinction rates and the loss of variety within species and across ecosystems. Increasingly, large companies are committing to address their impacts on biodiversity, but research shows that corporate reporting remains inconsistent, shallow, and difficult to compare. While biodiversity-related disclosures have largely been driven by various
There is an increased need for floors that can accommodate different type of sensitive equipment [1]. Further, it is recommended to design these floors as high frequency floors (HFF) to be able to meet the stringent vibration criteria [1]. This work used experimental measurements and numerical simulations to gain a deeper knowledge about the measurement, prediction and evaluation of vibrations in
Urban expansion is a defining feature of rapidly growing cities and has important implications for urban thermal behaviours, particularly in hot and semi-arid regions that are increasingly vulnerable to the effects of climate change. Tripoli, the capital of Libya, has experienced substantial urban growth over recent decades under conditions of weak planning and uneven development. Despite this, th
Uppsatsen syftar till att undersöka hur miljöförsvarare kan skyddas inom EUrätten i utövandet av civil olydnad. Syftet baseras till stor del på- och inspireras av Guidelines on Peaceful Environmental Protest and Civil Disobedience som Specialrapportören för miljöförsvarare under Århuskonventionens nyligen har publicerat. Vidare bygger uppsatsen på ett antal internationella konventioner för att und
This thesis examines how freedom of expression and misinformation are governed within contemporary digital environments, focusing specifically on the relationship between platform governance on X and international human rights discourse developed by the United Nations Human Rights Council. As social media platforms increasingly shape political communication and public debate, questions regarding w
This thesis examines how brand positioning of beauty brands, differentiating between high-end and mass-market, influences the engagement rate of consumers on Instagram and TikTok, and explores the role of platform type and content likability in explaining this relationship. As social media continues to shape the way consumers interact with brands, engagement metrics have become key indicators of s
This thesis investigates the predictability of returns on Research and Development (R&D) investments among leading European innovation-driven firms. R&D is the engine of long-term economic growth and corporate competitive advantage, yet its returns are notoriously uncertain due to high information asymmetry and long gestation periods. Traditionally, financial analysts and researchers have
BACKGROUND: Many factors influence housing choices among older adults, but far from all have been identified. There is little systematic analysis that has included economic factors and virtually no knowledge about the interplay among perceived costs of moving, health status, and the mobility rate of older homeowners. It is currently unclear whether economic factors influence older adults' willingn
