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The pandemic of chronic non-communicable diseases (NCDs) poses substantial challenges to the health financing sustainability in high-income and low/middle income countries (LMICs). The aim of this review is to identify the bottle neck inefficiencies in NCDs attributable spending and propose sustainable health financing solutions. The World Health Organization (WHO) introduced the "best buy" concep
1. The postnatal development of nociceptive withdrawal reflexes was studied. In awake intact rats, forelimb, hindlimb and tail reflexes were recorded on videotape. In decerebrate spinal rats, electromyography (EMG) was used to record nociceptive withdrawal reflexes in musculi extensor digitorum longus (EDL), peronei, gastrocnemius-soleus (G-S) and biceps posterior-semitendinosus (BP-ST). Thermal (
The European Union (EU) has laid down very clear objectives for the reduction of greenhouse gases in the hope that it will prevent or mitigate climate change. Political incentives are used to make the power industry adopt changes in order to reach these EU targets. In this thesis, some solutions that could help power companies meet the EU objectives are evaluated. Thermodynamic models have been de
The main purpose of this project has been to examine the accessibility of refereed conference articles and the OAand publishing policies of conferences in order to in this way elucidate different aspects concerning self-archiving in Swedish institutional repositories. For this purpose, the project participants have examined a number of conferences and references to conference articles via their in
Background: Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. Methods: Sixty healthy subjects 25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m(2)) were included in a cross-over study with 5 hours of
Objective Arterial pulse contour analysis is gaining widespread acceptance as a monitor of continuous cardiac output (CO). While this type of CO measurement is thought to provide acceptable continuous measurements, only a few studies have tested its accuracy and repeatability under unstable hemodynamic conditions. We compared continuous CO measurement using the pulse contour method (PCCO) before a
Over the past decade, circular strategies have been gaining momentum in the construction sector in an effort to reduce resource consumption, waste generation and environmental impacts. This transition requires not only changes in the construction process but also transformations in the constellation of actors involved. Previous research has mapped actors in circular construction and emphasised the
The COVID-19 pandemic led to substantial changes in working conditions in academia. This study aimed to explore how academics’ perceptions of job demands,resources and occupational well-being have changed since the COVID-19 pandemic, as well as their expectations and concerns regarding future working practices. To achieve this aim, we conducted a qualitative follow-up study with 16academics who pa
Background Subcutaneous emicizumab prophylaxis is increasingly used for early prophylaxis in infants with severe hemophilia A (SHA). Although the HAVEN 7 trial (NCT04431726) reported on 55 infants with SHA, real-world information regarding factor (F)VIII exposure, inhibitor development, and bleeding on this age group remains limited. Objectives To describe FVIII exposure, model-based annualized bl
Summary: In this population-based study, we compared the incidence of distal radius fracture in 2016 with that in the same region’s adult general population in 2001 using radiographs to identify fracture cases. We showed that the incidence decreased by 24% in 2016 compared with 2001 indicating an important development. Introduction: We conducted an epidemiological study on residents of northeaster
This Phase I study investigated the recommended Phase II dose (RP2D) of inotuzumab ozogamicin (InO), a CD22-directed antibody-drug conjugate, in pediatric patients with multiple-relapsed/refractory (R/R) CD22-positive acute lymphoblastic leukemia (ALL). Patients (≥1-<18 years) received three InO doses (Days 1, 8, 15) per course. Dose-escalation was based on dose-limiting toxicities (DLT) during Co
Barnets bästa är en av grundprinciperna i barnkonventionen. Det är ett kom-plext och dynamiskt begrepp som får sin innebörd genom en konkretisering av konventionens övriga artiklar. Av artikel 19 i barnkonventionen följer att barn har en absolut rättighet att skyddas från alla former av fysiskt eller psy-kiskt våld. I en rapport gjord av Jämställdhetsmyndigheten 2022 framgår att uppgifter om våld The best interests of the child is one of the fundamental principles of the Con-vention on the Rights of the Child (CRC). It is a complex and dynamic con-cept that derives its meaning through the concretization of the other articles of the convention. According to Article 19 of the CRC, children have an absolute right to be protected from all forms of physical or psychological violence. A report b
Annual cropping systems dominate agricultural grain production, but have been linked to several key environmental issues, such as loss of biodiversity and pollution of groundwater. Newly developed perennial grains may offer solutions to some of those problems. Their longer roots and growing seasons theoretically enable them to act as sinks of atmospheric carbon. This study set out to compare soil-
