Filtyp
The main protease Mpro, nsp5, of SARS-CoV-2 (SCoV2) is one of its most attractive drug targets. Here, we report primary screening data using nuclear magnetic resonance spectroscopy (NMR) of four different libraries and detailed follow-up synthesis on the promising uracil-containing fragment Z604 derived from these libraries. Z604 shows time-dependent binding. Its inhibitory effect is sensitive to
Build a linear accelerator to demonstrate spallation – the source of high-energy neutrons used by the new European Spallation Source being built in Sweden.In this activity, we build a model of a linear accelerator (linac) called a Gauss cannon. It uses magnetic attraction and momentum transfer to accelerate a series of steel balls, representing protons. At the end of the track, one ‘proton’ will cBuild a linear accelerator to demonstrate spallation – the source of high-energy neutrons used by the new European Spallation Source being built in Sweden.In this activity, we build a model of a linear accelerator (linac) called a Gauss cannon. It uses magnetic attraction and momentum transfer to accelerate a series of steel balls, representing protons. At the end of the track, one ‘proton’ will c
The central complex (CX) is a highly conserved region of the insect brain, and its ubiquitous occurrence suggests that its neural circuits are of fundamental importance. While its overall layout has not changed since the evolution of insect flight, substantial variations exist in the internal organization of all CX components. By changing the details of a system of repeating columns and layers, th
Popular Abstract in English Among the forms of life found in extreme environments (e.g. high temperatures ‘thermo’ and oxygen deficient ‘anaerobe’), the thermoanaerobic bacteria emerge as a highly evolved and interesting subject of study. Bacteria living as microbial mats in decaying plant material possess a great potential not only to degrade complex biomass but also to produce special chemicals.A novel ethanol-producing thermoanaerobe Caloramator boliviensis 45BT (=DSM 22065T, =CCUG 57396T) was isolated from a hot spring of the Bolivian highlands. C. boliviensis possesses the ability to utilize a wide range of substrates and can efficiently convert hexoses and pentoses into ethanol with concomitant production of acetate, carbon dioxide and hydrogen as by-products of fermentation. However
Popular Abstract in Swedish Med snabbare och pålitligare analysresultat finns stora möjligheter till ett ökat utnyttjande av avfallsresurser för produktion av förnybar energi. Resultat från min forskning gör det möjligt att analysera råvaror för biogasproduktion med större säkerhet och med möjligheten att få upp till nio gånger snabbare resultat. Produktion av biogas har under den senaste tiden öA sustainable treatment of organic wastes, generation of renewable energy, reduction of green house gas emissions, limiting the eutrophication and closing the nutrient cycles are several environmental challenges for which anaerobic digestion may be a suitable solution. There is today a large amount of available organic waste materials that could serve as potential feedstock for biogas production.
Objectives: To describe the pattern of drug resistance at virological failure in the NEAT001/ANRS143 trial (first-line treatment with ritonavir-boosted darunavir plus either tenofovir/emtricitabine or raltegravir). Methods: Genotypic testing was performed at baseline for reverse transcriptase (RT) and protease genes and for RT, protease and integrase (IN) genes for patients with a confirmed viral
Crystalline Cs2KMnF6, when prepared below 500°C, adopts a tetragonal elpasolite structure type. Differential scanning calorimetric investigations indicated that Cs2KMnF6 undergoes a phase transition from the low-temperature tetragonal phase (LT) to a high-temperature phase (HT) at about 530°C. Single crystals of the new HT phase could be obtained by annealing a crystalline LT specimen at 600°C fol
OBJECTIVE: Patients with non-muscle-invasive bladder cancer are traditionally followed by repeat cystoscopy and urine cytology. A fluorescence in situ hybridisation technique called UroVysion((R)) (UV) is now available for clinical diagnosis of urothelial cancer cells. The aim of the present study was to compare UV analysis with routine follow-up methods. METHODS: We studied an unselected cohort o
Popular Abstract in English The global energy consumption is increasing regularly due to the increased population and economic development. In contrast the primary energy sources, fossil fuels, are declining substantially. The combustion of fossil fuels contributes to the global climate change via greenhouse effects. To minimize these negative effects a carbon-neutral energy production is demandedThe electrochemical communication between microorganisms and electrodes has substantial implications both for basic understanding of biological electron transfer as well as in diverse applications, such as, microbial electrochemical system (MES), microbial biosensors and in production of valuable chemicals. In these systems the extracellular electron transfer (EET) from microbial metabolism to ele
Popular Abstract in Swedish Avhandlingen beskriver fonologin, morfologin och syntaxen för Lalo-språket, närmare bestämt som detta talas i Longjie landsortskommun i provinsen Yunnan i Kina. Lalo är ett språk som talas av ca 500 000 människor i sydvästra Kina. Språket tillhör burmesisk-yipho-språken, och har SOV-ordföljd, toner, fonationstyp, klassmärken m m. Avhandlingen är baserad på fältdata, iThe thesis is a descriptive reference grammar of the present-day Lalo language as spoken in Longjie township in Yunnan province of Southwestern China. It constitutes a presentation of empirical data collected during field work in Longjie township, and includes as survey of the phonology, morphology and syntax of the language. A word-list as well as text samples are appended to the thesis. Lalo is
In this paper, an algorithm for projective reconstruction of general 3D-curves from a number of its 2D-images taken by uncalibrated cameras is proposed. No point correspondences between the images are assumed. The curve and the view points are uniquely reconstructed, modulo projective transformations. The algorithm is divided into two separate algorithms, where the output of the first is used as i
Nanostructures have many material, electronic, and optical properties that are not found in bulk systems and that are relevant for technological applications. For example, nanowires realized from III-V semiconductors can be grown into wurtzite crystal structure. This crystal structure does not naturally exist in bulk where these materials form the zinc-blende counterpart. Being able to concomitant
A new predictive formula for the total longshore sediment transport (LST) rate was developed from principles of sediment transport physics assuming that breaking waves mobilize the sediment, which is subsequently moved by a mean current. Six high-quality data sets on hydrodynamics and sediment transport collected during both field and laboratory conditions were employed to evaluate the predictive
To understand the Mesa- and Neoarchaean geological history of the Bjornesund region, southern West Greenland (ca. 62-63 degrees N), we have undertaken an integrated study combining field observations with U-Pb zircon geochronology by LA-ICP-MS, metamorphic petrology, and microstructural analyses. The Bjornesund region links the southern part of the Fiskenaesset anorthosite complex to the well-pres
Results are presented from data recorded in 2009 by the PHENIX experiment at the Relativistic Heavy Ion Collider for the double-longitudinal spin asymmetry, A(LL), for pi(0) and eta production in root s = 200 GeV polarized p + p collisions. Comparison of the pi(0) results with different theory expectations based on fits of other published data showed a preference for small positive values of gluon
Like many animals migrating through the oceans, sea turtles face difficult navigational tasks when they have to reach distant, specific sites. The paradigmatic case of Brazilian green turtles (Chelonia mydas), which nest on the tiny Ascension Island in the middle of the Atlantic Ocean, has often been the subject of hypotheses concerning their navigational mechanisms. To investigate their nature, w
Software is an increasing and important part of many products and systems. Software, hardware, and system level components have been developed and produced following separate processes. However, in order to improve the quality of the final complex product, requirements and prospects for an automatic integrated process support are called for. Product data management (PDM) has focused on hardware pr
Coreceptor use was determined for human immunodeficiency virus type 1 (HIV-1) isolates of various subtypes from 11 women during pregnancy and their infected children. Isolates from peripheral blood mononuclear cells (n = 79) and from plasma (n = 59) were available. The clinical and immunological stages of HIV-1 infection were recorded. Coreceptor use was tested on human cell lines expressing CD4 a
