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PURPOSE: To establish the safety and tolerability of ZD1839 (Iressa), a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, and to explore its pharmacokinetic and pharmacodynamic effects in patients with selected solid tumor types. PATIENTS AND METHODS: This was a phase I dose-escalating trial of oral ZD1839 150 mg/d to a maximum of 1,000 mg/d given once daily for at least
When a shotgun phage-display library of Staphylococcus aureus Newman was affinity selected (panned) against recombinant von Willebrand factor (vWf), a novel von Willebrand factor binding protein (vWbp) was found. Experimental data indicate that the interaction between vWbp and vWf is very specific and mediated by a region of 26 aa residues in the C-terminal part of vWbp. vWbp has an N-terminal sec
In order to obtain a wide set of test cases for numerical methods to solve Smoluchowski's coagulation equation the exact solutions for the constant, sum or product kernel, with gamma distributions as initial size spectra, are generalized by allowing size distributions with a singularity at zero volume. (C) 2004 Published by Elsevier Inc.
Popular AbstractSyftet med avhandlingen är att undersöka på vilket sätt teater med ungdomar, enligt ungdomarnas egna erfarenheter och utsagor om det, utgör en kollektiv bildningsprocess. I avhandlingens syfte ingår att analysera hur en teaterföreställning växer fram och att skapa förståelse för vad som sker mellan olika aktörer, främst mellan ungdomar och ledare.Forskningsfenomenet, unga människorThe objective of this research project is to investigate in what way young people's theatre playing, according to their own experiences, constitute a collective educational process. Also, the project aims at understanding the interaction between the different actors, and particularly between the young amateurs and their leaders. Young people's acting in this research project is understood from a p
Professionals who take part in the building process have long been concerned with the same environmental factors, e.g. spatial layout, capacity, and function, as well as user demography. Through the knowledge gained on the ways environmental factors affect users of buildings, the need to understand how to handle these factors has grown, due to their influence on the building process. It will be sh
Immunohistochemistry has been used to demonstrate that neuropeptide Y, dopamine-beta-hydroxylase, calcitonin gene-related peptide or substance P are colocalized with vasoactive intestinal polypeptide and choline acetyltransferase in subpopulations of neurons in cranial parasympathetic ganglia of rat. These comprise the ciliary, sphenopalatine, otic, glossopharyngeal-vagal and internal carotid gang
Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is uncertain and may depend on the context. Estimates based on multiple-case families may be enriched for mutations of higher risk and/or other familial risk factors, whereas risk estimates from studies based on cases unselected for family history have been imprecise. We p
Target factors aim at setting criteria to select foreign vessels that should be inspected by port state control authorities. Although a relative consensus exists on the main factors to consider in selecting vessels, the weight to be given to these factors is still unclear. Using data on 26 515 PSC inspections that took place within the Indian Ocean MoU region from 2002 to 2006, we investigate the
Transgenic Huntington's disease (HD) mice, expressing exon 1 of the human HD gene (lines R6/1 and R6/2), are totally resistant to striatal lesions caused by the NMDA receptor agonist quinolinic acid (QA). Here we show that this resistance develops gradually over time in both R6/1 and R6/2 mice, and that it occurred earlier in R6/2 (CAG-155) than in R6/1 (CAG-115) mice. The development of the resis
Conclusions. The presented analysis of nasal polyposis using connectivity based on the PubGene literature co-citation network demonstrates that this tool can be used to identify key genes in DNA microarray studies of human polygenic diseases. Objectives. DNA microarray studies of complex diseases may reveal differential expression of hundreds of genes. According to network theory and studies of ye
This study aims to forecast the Swedish FCR-D Down A2 market prices through a hybrid model combining a volatility model and a machine learning approach, and compares its performance with a standalone machine learning model. We further examine the impact of different lag orders (1-Hr vs. 24-Hr) on volatility estimates and forecast performance. Evaluation metrics include root of mean squared error (
The ‘policy window hypothesis’ in the context of extreme climate events, refers to a phenomenon whereby adaptation action is facilitated and occurs directly in response to extreme climate events. Despite the intuitive logic that extreme climate events may provide useful opportunities to design and implement successful adaptation policies, the literature suggests that this is not the case. With thi
Syfte: I uppsatsen kommer vi utgå från fenomenet grrlzines för att undersöka och analysera dem. För att kunna genomföra detta kommer vi använda oss av teorier angående feminismens utveckling varvat med språk- och kommunikationsteorier. Frågeställningar: Våra frågeställningar är: -Vad kännetecknar grrlzines diskussionsgrupper vad beträffar form? -Vilka ämnen diskuteras i diskussionsgrupperna? -Vad
Medierna spelar en allt större roll i våra vardagliga liv, de bestämmer vad vi får ta del av respektive inte får ta del av. Detta har stor betydelse för vår identitetsbildning och vår syn på genus, i synnerhet inom populärkulturen. Vi har valt att undersöka de kvinnliga och manliga könsrollerna som presenteras i relity-tv serien Ullared. Serien presenterar det vardagliga livet på shoppingparadiset
Innovation is gospel today. This also means a surge in popularity for the agents behind innovation; innovators. But who are they, exactly? Anecdotal evidence from both recent times and historical settings tend to emphasize remarkable individuals, who more or less alone created amazing things. By utilizing the SWINNO-database of innovations, this thesis examines how empirically prevalent the narrat
This study presents reconstructions of black carbon (BC), including spheroidal and amorphous carbonaceous particles (SCP and ACP), organic matter (OM; total organic carbon, TOC; total nitrogen, TN; total sulfur, TS), and heavy metals (Fe, Zn, Pb, Cu, As and Hg) in coastal sediments off the south-west coast of Sweden. Sediment records from eight stations along a north-south transect off the south-w
The four fundamental freedoms of the European Community include free movement of goods, free movement of workers, freedom of establishment and provision of services and free movement of capital. The purpose of the freedoms is to ensure the realisation of the Internal Market within the Community. As one of the freedoms the freedom of establishment is of great importance for the integration of the M
This thesis analyses the impact of EU citizenship on EU citizens studying in another EU Member State, Lund, Sweden in order to find out whether there is an ‘added value’ for EU citizens when exercising their rights as EU citizens. In the first part, a short introduction to the background of EU citizenship, the rights it grants and student mobility in the EU is presented. The second part illustrate
