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Background: Optimal adjunctive therapy in ST-segment elevation myocardial infarction (STEMI) patients treated with primary PCI (PPCI) remains a matter of debate. Our aim was to compare the efficacy and safety of bivalirudin to unfractionated heparin (UFH), with or without glycoprotein IIb/IIIa inhibitors (GPI) in a large real-world population, using data from the Swedish national registry, SWEDEHE
At synchrotron light storage rings there is demand for serving high-brilliance users requesting multibunch operation while simultaneously serving timing users who require single-bunch operation. One method to accomplish this is PPRE developed and currently in user operation at BESSYII. In the method, the transverse emittance of one of the bunches in the bunch train is increased by an incoherent beAt synchrotron light storage rings there is demand for serving high-brilliance users requesting multibunch operation while simultaneously serving timing users who require single-bunch operation. One method to accomplish this is PPRE developed and currently in user operation at BESSY II. In the method, the transverse emittance of one of the bunches in the bunch train is increased by an incoherent b
European countries have been receiving refugee children for decades with a recent peak in 2015/2016 (Crul 2017). Although the number of refugees currently arriving in Europe must be seen in proportion to the much higher percentage of refugees that remain in states outside European borders (Dryden-Peterson 2016), the inclusion of refugee children is perceived as a major challenge by policy makers a
The aim of this follow-up study has been to assess retinopathy and change of treatment to insulin therapy as risk factors for mortality in diabetic patients participating in a control and screening programme for retinopathy. A total of 3220 diabetic patients, 483 with an age at diagnosis <30 years, and 2737 with an age at diagnosis ≤30 years, were included. Retinopathy was graded on fundus photogr
Dysfunction of the gastrointestinal tract has now been recognized to affect all stages of Parkinson's disease (PD). The consequences lead to problems with absorption of oral medication, erratic treatment response, as well as silent aspiration, which is one of the key risk factors in developing pneumonia. The issue is further complicated by other gut abnormalities, such as small intestinal bacteria
Aim: Analysis of age at time of detection and surgery of dense unilateral cataract and investigation of best-corrected visual acuity (BCVA) in a nationwide register-based cohort study, based on the routine of maternity ward eye screening. Methods: Data were derived from the Paediatric Cataract Register (PECARE). All children (n = 54) diagnosed with dense congenital unilateral cataract between Janu
Background and ObjectiveExperimental studies suggest that the balance between short and long β-amyloid (Aβ) species might modulate the toxic effects of Aβ in Alzheimer disease (AD), but clinical evidence is lacking. We studied whether Aβ38 levels in CSF relate to risk of AD dementia and cognitive decline.MethodsCSF Aβ38 levels were measured in 656 individuals across 2 clinical cohorts: the Swedish
Background: Comparisons of second-line anti-tumour necrosis factor (TNF) agents and vedolizumab are sparse. Aim: To evaluate the effectiveness of anti-TNF agents compared to vedolizumab as second-line biologics in inflammatory bowel disease (IBD). Methods: A propensity score-matched cohort was created using Swedish nationwide registers. Patients with Crohn's disease or ulcerative colitis, exposed
Seven species new to science are described, illustrated and compared with closely related taxa. Of them, one species, i.e.: Coppinsidea vernadskiensis S. Y. Kondr., T. O. Kondratiuk et I. Yu. Parnikoza is from the Argentine Islands, Western Maritime Antarctic Peninsula, Jacke lixia hosseussii S. Y. Kondr., L. Lőkös et J.-S. Hur, from South America (Argentina and Uruguay), Loekoeslaszloa reducta Yo
Background: Many severe asthma patients with high oral corticosteroid exposure (HOCS) often do not initiate biologics despite being eligible. This study aimed to compare the characteristics of severe asthma patients with HOCS who did and did not initiate biologics. Methods: Baseline characteristics of patients with HOCS (long-term maintenance OCS therapy for at least 1 year, or ≥4 courses of stero
Wastewater treatment processes are inherently dynamic because of variations in the influent flow rate, concentration, and composition. The adaptive behaviour of the microorganisms further emphasizes this fact. Mathematical models and computer simulations are essential to describe, predict, and control the complicated interactions of the processes. Any attempt to model all details of the various re
Background/objectives: Alzheimer’s disease (AD) is currently diagnosed clinically using defined symptomatic diagnostic criteria. Pathological levels of CSF-biomarkers, high T-tau, P-tau and low Ab42 have been associated with AD however definition of cut off values differ. New diagnostic criteria that include the pathological CSF biomarkers have been suggested. How many AD patients in a routine cli
The importance of social circumstances for middle-age women’s general subjective well-being (SWB) was investigated in a representative sample of Swedish women, age 43 (N = 369). The results showed non-existent to moderate relationships between a number of social circumstances variables and general SWB. The strongest relationship was found between marital status and global life satisfaction. Being
Bacteria and fungi, representing two major soil microorganism groups, play an important role in global nutrient biogeochemistry. Biogeographic patterns of bacterial and fungal biomass are of fundamental importance for mechanistically understanding nutrient cycling. We synthesized 1323 data points of phospholipid fatty acid-derived fungal biomass C (FBC), bacterial biomass C (BBC), and fungi:bacter
OBJECTIVES: Analyses performed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) identified cut-points in several metrics of grip strength for consideration in a definition of sarcopenia. We describe the associations between the SDOC-identified metrics of low grip strength (absolute or standardized to body size/composition); low dual-energy x-ray absorptiometry (DXA) lean mass as previo
In modern aquaculture, animal-production technology is used to increase aquatic food sources. Such controlled rearing of seafood can, in principle, shift the pressure off wild stocks and aquatic ecosys- tems by reducing fishing activities, which may advance marine conservation goals. We examined resource displacement—the reduced consumption of a resource due to its replacement with a more environm
Background: Allergen avoidance is important in allergic asthma management. Nocturnal treatment with Temperature-controlled Laminar Airflow (TLA) has been shown to provide a significant reduction in the exposure to allergens in the breathing zone, leading to a long-term reduction in airway inflammation and improvement in Quality of life (QoL). Allergic asthma patients symptomatic on Global Initiati
OBJECTIVES: To evaluate serum creatinine (s-creatinine) and serum cystatin C (s-cystatin C) levels and estimated glomerular filtration rate (eGFR) at different time points as predictors for mortality in patients undergoing coronary artery bypass grafting (CABG).METHODS: A total of 1638 patients undergoing elective CABG were studied prospectively over a median follow-up of 3.5 years (range, 2.0-5.0
Smaller size and lower weight are always the targets of the power electronic product development. This work introduces two new topologies of auxiliary converters which have the feature of fewer components and fewer number of energy conversion stages comparing with the conventional auxiliary converter used in railway applications. The initial proposal of the proposed new topology is based on the id
BACKGROUND: Patients who misuse alcohol are at increased risk for surgical complications. Four weeks of preoperative abstinence decreases the risk of complications, but practical approaches for early preoperative identification of alcohol misuse are needed. OBJECTIVE: To evaluate whether results of alcohol screening with the Alcohol Use Disorders Identification Test - Consumption (AUDIT-C) questi
