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Background Inversions involving intron 22 (Inv22) of the F8 gene are detected in approximately 45% of all severe hemophilia A (HA) patients. Digital droplet polymerase chain reaction using milepost assays and multiplex ligation-dependent probe amplification (MLPA) allows robust diagnosis of inversions, copy number variations, and more complex rearrangements in F8 . Objectives A total of 350 HA pat
Background: The Peritoneal Cancer Index recorded at laparotomy is based on visual and palpable inspection of peritoneal surfaces for disease. This study aimed to analyze interobserver variation in assigning the lesion score (LS) and morphologic term (MT) to characterize peritoneal lesions (PL) and predict the probability of malignancy (POM) among surgeons with expertise in cytoreductive surgery (C
Background The aim of this systematic review and meta-analysis was to examine autoantibody positive individuals and define: (a) the relative risk of rheumatoid arthritis (RA) compared with autoantibody negative individuals and (b) the cumulative incidence of RA over time, in different populations. Methods A systematic literature search was performed in August 2025. Retrospective case control studi
Extractivism is a global phenomenon driven by the logic of capitalism that is manifested chiefly in mining, but also in agribusiness. Women around the world have emerged as leaders of resistance movements against extractivism. In this article, we question this recurrent theme in political ecology literature based on ethnographic fieldwork in southern Ecuador, where resistance has been less success
Breastfeeding confers a wide range of benefits to mothers and children, and in many contextsmay continue for several years after the birth of a child. As a result, breastfeeding duringpregnancy (BDP) is a common occurrence throughout low- and middle-income countries.Nevertheless, yet there has been little research into its association with the health of breastfedchildren or the outcomes of the pre
Background Multimorbidity, the co-occurrence of two or more non-communicable diseases (NCDs), is common and has been linked to venous thromboembolism (VTE). Whether multimorbidity diagnosed in primary-care is associated with incident VTE remains unclear. We aimed to examine this association. Methods Multimorbidity was defined using Swedish primary-care data. Individuals without prior VTE were incl
To examine longitudinal trajectories of pain occurrence in children with cerebral palsy (CP) aged 1 year to 17 years.A longitudinal register-based study was conducted using data from the Swedish Cerebral Palsy Follow-up Program (2007-2023). Individuals (n = 4887) with confirmed CP, a minimum of three pain assessments, and any Gross Motor Function Classification System (GMFCS) levels were included
The aim of the present study was to find clinical parameters affecting incidence and progression of nephropathy in type 2 diabetic patients. A prospective study for 10 years was performed in 385 type 2 diabetic patients (diabetes diagnosis > or =30 years) attending a hospital-based outpatient clinic. Medical risk indicators like diabetes duration, HbA(1c), and blood pressure were related to the de
Background and aims: Several studies report a high prevalence of memory complaints in the elderly, non-demented population. Since the pathogenesis and diversity of memory impairment in healthy people is still an unresolved issue, we designed our study to ascertain the occurrence of brain abnormalities in Age-Associated Memory Impairment (AAMI) by measuring regional cerebral blood flow (rCBF). Meth
Previously, we have shown that short-term administration of adrenocorticotrophic hormone (ACTH) results in reduced concentrations of apolipoprotein B-containing lipoproteins, including lipoprotein(a), and reduced activities of hepatic lipase. These effects were observed in steroid-treated patients suffering from iatrogenic ACTH deficiency and in healthy individuals. The direct nature of the influe
In this study, we examined the onset and duration of local analgesic effects of bupivacaine incorporated into biodegradable microcapsules (extended-duration local anesthetic; EDLA) administered as subcutaneous infiltrations in different doses in humans. In 18 volunteers, the skin on the medial calf was infiltrated with 10 mL of EDLA, and the opposite calf was infiltrated with 10 mL of aqueous bupi
This study was performed to elucidate circulatory changes in the fetal cerebral circulation during uncomplicated labor and in early neonatal life. Eighteen healthy term singleton fetuses were followed longitudinally during labor. Using the transabdominal approach, and the color Doppler technique, the middle cerebral artery was identified and Doppler flow velocity waveforms recorded between and dur
Objective To evaluate the outcome of screening for structural malformations in twins and the outcome of screening for twin-twin transfusion syndrome (TTTS) among monochorionic twins through a number of ultrasound scans from 12 weeks' gestation. Methods Enrolled into this prospective multicenter observational study were women with twin pregnancies diagnosed before 14 + 6 gestational weeks. The mono
