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Why European and United States drug regulators are not speaking with one voice on anti-influenza drugs: regulatory review methodologies and the importance of 'deep' product reviews

BackgroundRelenza represents the first neuraminidase inhibitor (NI), a class of drugs that also includes the drug Tamiflu. Although heralded as breakthrough treatments in influenza, NI efficacy has remained highly controversial. A key unsettled question is why the United States Food and Drug Administration (FDA) has approved more cautious efficacy statements in labelling than European regulators f

The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

Popular Abstract in English Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and the balanced cellular dNTP pools are of extreme importance to maintain the genomic stability and overall function of the cell. Primarily, two different pathways exist in most of the organisms that are responsible for providing dNTPs. One is called the de novo pathway where dNTPs are formed fromThe synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc., while in the other pathway, dNTPs are formed by salvaging intra- or

Clustering of back-end failures in automated testing

Automated Software testing is becoming increasingly popular, which in turn creates more information that has to be analyzed. At the software company Qlik a tool called NIOCAT is used to create clusters of failed test cases thought to originate from the same code defect. The clustering is done in order to decrease the ever increasing amount of manual analysis needed to be done with regards to softw

SIMIND Based Pinhole Imaging Development and Validation

The Monte Carlo method has become increasingly used to simulate imaging systems like the scintillation camera and SPECT systems. In order to investigate intrinsic properties of SPECT systems the Monte Carlo based application SIMIND (Simulating Medical Imaging Nuclear Detectors) has been developed. Up to now, it has not been able to simulate a pinhole-imaging device with SIMND. The aim of this work

Using Satellite Data on Nighttime Lights Intensity to Estimate Contemporary Human Migration Distances

For well over a century, migration researchers have recognized the lack of adequate distance measures to be a key obstacle for advancing understanding of internal migration. The problem arises from the convention of spatially defining migration as the crossing of administrative borders. Since administrative regions vary in size, shape, and settlement patterns, it is difficult to tell how far moverFor well over a century, migration researchers have recognized the lack of adequate distance measures to be a key obstacle for advancing understanding of internal migration. The problem arises from the convention of spatially defining migration as the crossing of administrative borders. Because administrative regions vary in size, shape, and settlement patterns, it is difficult to tell how far mov

Internalization of secreted antigen-targeted antibodies by the neonatal Fc receptor for precision imaging of the androgen receptor axis

Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. A

A critical narrative review of assistive robotics and call for a systems and user-centered approaches to enhance quality of life of individuals with disabilities

Background: Despite the rapid pace of assistive robotics development, adoption of these has been limited. This raises questions such as: What contributes to this low uptake? What strategies could be employed to increase uptake? What guidance can be found in the literature to inform alternative approaches or directions for development?Objective: This critical narrative review sheds light on the de-

Edgeworth expansions for multivariate random sums

The sum of a random number of independent and identically distributed random vectors has a distribution which is not analytically tractable, in the general case. The problem has been addressed by means of asymptotic approximations embedding the number of summands in a stochastically increasing sequence. Another approach relies on fitting flexible and tractable parametric, multivariate distributionThe sum of a random number of independent and identically distributed random vectors has a distribution which is not analytically tractable, in the general case. The problem has been addressed by means of asymptotic approximations embedding the number of summands in a stochastically increasing sequence. Another approach relies on fitting flexible and tractable parametric, multivariate distribution

Isolation and some properties of an IgG Fc-binding protein from group A streptococci type 15

An IgG Fc-binding protein was isolated from alkaline extracts of group A streptococci type 15 by ion-exchange chromatography and immunosorption on an IgG column. Ample use of protease inhibitors was necessary to achieve successful isolation. 600 micrograms protein was obtained from 60 g bacteria (wet weight). The protein appeared homogeneous on agarose gel and sodium dodecyl sulfate polyacrylamide

Podd: Den eftertraktade medicinen mot fetma – Vetenskap och Hälsa

Podd: Den eftertraktade medicinen mot fetma – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Podd: Den eftertraktade medicinen mot fetma 2024-03-15 Vetenskap & hälsa · Den eftertraktade medicinen mot fetma Medicinen har omtalats som en revolution inom fetmabehandlingen. Den har fått kilona

https://www.vetenskaphalsa.se/podd-den-eftertraktade-medicinen-mot-fetma/ - 2026-05-09

Catherine Westfall

Institutets och temat Exploring Challenges for New Big Science gästforskare 2014-2015 Några ord från Catherine Westfall om sig själv och arbetet i temat I have always happily worked in an interdisciplinary environment.  As a professor teaching the history of science and technology I am part of a faculty that includes physicists, chemists, mathematicians, biologists as well as historians, sociologi

https://www.pi.lu.se/teman/gastforskare/catherine-westfall - 2026-05-09

Reaction of Peroxomonosulfate Radical with Manganese(II) in Acidic Aqueous Solution. A Pulse Radiolysis Study

The reaction between the SO5– radical and MnII has been proposed to be the most important process for regeneration of MnIII in the MnIII/II-catalysed autoxidation of SIV in acidic aqueous solution. In the present study, the second-order rate constant for this reaction has been determined at pH 3. 0 and 10 mmol dm–3 ionic strength by use of pulse radiolysis. The study was performed in the presence

Doctoral Thesis: Massive MIMO in Real Propagation Environments

Popular Abstract in English Mobile communication systems are now evolving towards the fifth generation (5G). In the near future, we expect an explosive increase in the number of connected devices, such as phones, tablets, wearable accessories, sensors, connected vehicles and so on. We can imagine that much higher data rates than in today's 4G systems are required. Sounds like the future of communiMobile communications are now evolving towards the fifth generation (5G). In the near future, we expect an explosive increase in the number of connected devices, such as phones, tablets, sensors, connected vehicles and so on. Much higher data rates than in today's 4G systems are required. In the 5G visions, better coverage in remote regions is also included, aiming for bringing the current "4 bill

Modification of Oxide Surfaces with Functional Organic Molecules, Nanoparticles, and Hetero-Oxide Layers

Popular Abstract in English It is hard to imagine present day’s lifestyle without the use of modern technologies as prevalent in sectors including bioscience & technology and the semiconductor & chemical industries. In technological advances of biosensors, catalysis, and microelectronics, the surface modification of materials (which includes modification of the wetting, structural, electriThe research work described in this thesis is concerned with the modification of oxide surfaces, as reflected by its title. The surfaces and their modification have been studied using a range of experimental surface characterization tools, in particular x-ray photoelectron spectroscopy (XPS), fluorescence microscopy, scanning electron microscopy, atomic force microscopy, and scanning tunneling mic

Landsbyggdens egnahem i Malmöhus Län 1905-1040. En studie av markförsäljningen till fastigheter som beviljades egnahemslån

During the period 1905 to 1940 it was possible to get a loan from the state to buy land and build a small farm or a house in rural areas. This loan act and its effects have been studied earlier in different ways, but never as a total study for a geographic region. The region Malmöhus Län has been chosen. The purpose of this paper is to study in which parts of the area loans were taken and who sold

Mall För OSA-enkät (svenska Engelska) 2022

Markera din organisationstillhörighet: / Select your organisational affiliation: Avdelning / Division a Avdelning / Division b Avdelning / Division c Avdelning / Division d Avdelning / Division e Avdelning / Division f Q1 Markera din yrkesgrupp: / Select your professional group: Professor Lektor / Senior lecturer Adjunkt / Lecturer Meriteringsanställning (postdoktor, biträdande lektor) / Career de

https://www.hr-webben.lu.se/sites/hr-webben.lu.se/files/2025-12/Mall%20f%C3%B6r%20OSA-enk%C3%A4t%20(svenska%20_%20engelska)%202022.pdf - 2026-05-11

Podd: Frisk vid typ 2-diabetes – Vetenskap och Hälsa

Podd: Frisk vid typ 2-diabetes – Vetenskap och Hälsa Vetenskap och hälsa Populärvetenskapligt om medicinsk forskning i Skåne Teman Podd Tidskrift Prenumerera Om webbplatsen Kontakt Sök Sök Podd: Frisk vid typ 2-diabetes 2025-05-23 Vetenskap & hälsa · Frisk vid typ 2-diabetes   En podd om hur en del kan lyckas reversera sin typ 2-diabetes genom viktnedgång, men också om hur andra med typ 2-diabetes

https://www.vetenskaphalsa.se/podd-frisk-vid-typ-2-diabetes/ - 2026-05-09

Doctoral thesis in biomedical engineering: AI analyses of magnetic resonance imaging examinations

Doctoral thesis in biomedical engineering: AI analyses of magnetic resonance imaging examinations Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvä

https://www.lth.se/article/doctoral-thesis-in-biomedical-engineering-ai-analyses-of-magnetic-resonance-imaging-examinations/ - 2026-05-09