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Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the iSoluble triggering receptor expressed on myeloid cells 2 (sTREM2) in cerebrospinal fluid (CSF) has been associated with Alzheimer's disease (AD). TREM2 plays a critical role in microglial activation, survival, and phagocytosis; however, the pathophysiological role of sTREM2 in AD is not well understood. Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the i

In conventional cell lysate protocols, cell debris is typically discarded to obtain a cleaner lysate. However, this approach has limitations, as it may overlook vital cellular components. By discarding cell debris, researchers may inadvertently exclude crucial elements. Retaining all cellular components offers several advantages for studying molecular biology within various cellular compartments. In conventional cell lysate protocols, cell debris is typically discarded to obtain a cleaner lysate. However, this approach has limitations, as it may overlook vital cellular components. By discarding cell debris, researchers may inadvertently exclude crucial elements. Retaining all cellular components offers several advantages for studying molecular biology within various cellular compartments.

AimTo understand service users' experiences of their current mental health services and explore reflections on the Flexible Assertive Community Treatment (FACT) model and its role in future practice.MethodsA total of 17 experts participated in individual and dyadic in-depth interviews. A reflexive thematic analysis was performed on the participants' experiences of current mental health services anBackground: A person-centred and recovery-oriented approach is an integral part of modern mental health services founded on the experiential knowledge of service users. Their reflections as experts, grounded in their unique experience as service users, play a significant role in developing and improving the existing care. Experiential knowledge is therefore a means to enhance the relevance of rese

International organisations (IOs) play increasingly important roles in world politics. As states face more complex challenges they have joined together in IOs to solve their common problems. Yet once an IO has been created it may take on a life of its own, and it becomes difficult for its state founders to control what it does. Permanent secretariats populated by experts are one of the most import

Popular Abstract in English Experiments, such as the Large Hadron Collider (LHC) in CERN, Switzerland, collide particles together at high energies, in the hope of probing the fundamental constituents and forces of nature. On the theoretical side, the Standard Model (SM) is currently the best description we have. It is a theory that encompasses the strong, weak and electromagnetic forces, although This thesis involves phenomenological models for describing high energy particle collisions. One class of these models, multiparton interactions (MPI), deals with the fact that when colliding two hadrons, it is possible for more than one pair of their constituents to interact. The other deals with parton showers, which are used to fill enhanced regions of phase space and give fully exclusive final

Misfolding, self-assembly, and subsequent deposition of amyloid β plaques and tau tangles are closely associated with Alzheimer’s disease (AD) and its neurodegenerative processes, driving healthy neurons into a diseased state. At present, AD is the most widespread form of dementia, causing profound personal and familial hardship as well as imposing a substantial societal economic burden.Currently,The purpose of the work that forms the basis of this thesis has been to investigate fundamental properties of amyloid β and tau self-assembly and their solubility. The results of this research are presented as five research articles. In Paper I, a solubility assay for determining the solubility of amyloid proteins is developed and its use demonstrated for the Aβ40 peptide. Paper II finds that tau

Promoting resource- and energy-efficient home lighting through technology and behaviour change requires an understanding of how residents currently use lighting and what they want from it. However, users’ needs and desires relating to lighting in homes are poorly understood, as research is still limited. This paper aims to provide a fuller picture of residents’ experiences with their homelighting.Promoting resource- and energy-efficient home lighting through technology and behaviour change requires an understanding of how residents currently use lighting and what they want from it. However, users' needs and desires relating to lighting in homes are poorly understood, as research is still limited. This paper aims to provide a fuller picture of residents' experiences with their home lighting

The aim of this paper is to find appropriate approximate expressions of the coherent electromagnetic field scattered by a particulate slab.The exact solution of the coherent electric field to the multiple scattering problem in the slab is determined by the solution of a set of integral equations. By iterating the integral equations, an approximate solution is obtained, which approximates the solutThe aim of this paper is to find appropriate approximate expressions of thecoherent electromagnetic field scattered by a particulate slab. The exact solution of the coherent electric field to the multiple scattering problem in the slabis determined by the solution of a set of integral equations. By iterating theintegral equations, an approximate solution is obtained, which approximatesthe solution

Introduction: In conventional medical linear accelerators, the flattening filter is introduced in the photon beam line to provide a uniform lateral dose profile at a specified depth in water. For some radiotherapy treatments, e.g. intensity modulated radiotherapy, a flat radiation field is not necessary and the flattening filter could be removed. Several studies have shown that removal of the filt

This normative study examines the Swedish governments solidarity security policy, in relation to its commitments in the EU and Nato. Since the end of the cold war, Sweden has shifted its security policy from one of neutrality, to one of solidary participation within said alliances. The study’s aim is to examine the validity of this policy, in relation to the concept of solidarity. In doing so, it

LTH project receives funding from Vinnova to plan future technology clusters Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbpla

https://www.lth.se/article/lth-project-receives-funding-from-vinnova-to-plan-future-technology-clusters/ - 2026-05-04

Universitetslektor Kontaktinformation E-post: thomas [dot] pugh [at] mgeo [dot] lu [dot] se Mobil: +46 46 222 86 97Organisation Miljö- och geovetenskapliga institutionen (MGeo) Rumsnummer: 363 Hämtställe: 16 WebbplatsThomas Pughs profil i Lunds universitets forskningsportalAndra roller Universitetslektor Institutionen för naturgeografi och ekosystemvetenskap Medlem i Strategiskt forskningsområde B

https://www.nateko.lu.se/sv/thomas-pugh - 2026-05-05

This paper tests the “Square Root Rule” (the SRR), a Basel sanctioned method of scaling 1-day Value At risk to higher time horizons. The SRR has come under serious assault from leading researchers focusing on its week theoretical basis: assuming i.i.d. asset returns. I performed an empirical test of the SRR on the 10-day horizon, the maximum horizon allowed by Basel, comparing SRR performance to d

The status of Western Sahara has since 1975 been a controversial topic in international relations. Morocco claims that the territory rightfully belongs to them while Polisario, the representative of the Sahrawi’s, are of the dichotomous opinion and demands independence. In this paper I will examine the statement that Western Sahara in the long run would be to weak and too poor to survive as a stat

Purpose: To evaluate and increase the efficiency of the internal processes by clearly visualizing the information flow and present improvement suggestions at Vestas Northern Europe.
Problem definition: To clearly define what information is shared today, identify where the critical interfaces take place and where vital information is lost.
Method: This study takes a her

Abstract Background: Osteoarthritis (OA) is the most common joint disorder globally and a major cause of disabiltiy with the knee joint responsible for 80% of the disease burden. Progressive degenerative changes in cartilage tissue result in deterioration and loss of articular cartilage. Cartilage has poor capacity of healing and the detection of degeneration usually occurs at a stage of progressi

Popular Abstract in Swedish Människan är uppbyggd av ett stort antal celler. För att kroppens olika organ ska kunna samverka och för att kroppen ska kunna fungera som en helhet, måste de olika cellerna kommunicera med varandra. Cellernas kommunikationssystem är uppbyggt av mottagare, s.k. receptorer, på de olika cellernas yta och signaler som skickas runt mellan cellerna. Receptorerna och signaleThe chemokine receptors CCR5 and CXCR4 are required, together with CD4, for the entry of HIV-1 into target cells. CCR5 using HIV-1 dominates during transmission and the asymptomatic phase of infection. During progression, virus phenotypes with the ability to use CXCR4 emerge in about 50% of infected individuals. Individuals continuously harbouring CCR5-restricted isolates still progress to AIDS. D

Nyhetsbrev - Öresundsnätverket för genus/kønshistoriskhistorisk forskning Öresundsnätverket för genus/kønshistorisk forskning samlar forskare från olika discipliner i syfte att utveckla och stärka genus/kønshistorisk forskning på båda sidor om Öresund. ”At gøre en ende på marokkanske voldtægtstragedier” Dokumentärfilm på KVINFOs bibliotek, 14 maj. Tid: 17-19. Se en dokumentarfilm, der var med til

https://www.cors.lu.se/sites/cors.lu.se/files/nyhetsbrevapril_okh.pdf - 2026-05-06

If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own