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User generated content (UGC) makes up a significant portion of Internet traffic. As opposed to other content, UGC has so far been left outside over-the-top providing network operators content distribution networks (telco-CDN) due to the difficulty in determining optimised placement of such content. The side effect of this is that UGC content is not placed close to end users and therefore occupy un
OBJECTIVES: Vesicular drug delivery has become a useful approach for therapeutic administration of pharmaceutical compounds. Lipid vesicles have found application in membrane biology, immunology, genetic engineering and theragnostics. This review summarizes topical delivery, specifically dermal/transdermal, ocular and transungual, via these vesicles, including future formulation perspectives. KEY
Several transporter systems in the liver and intestine are known to change their expression and function during cholestatic disease states. The objective of the-present in vivo study-was to investigate the effect of biliary depletion, as a method to mimic cholestasis, on the bioavailability and disposition of digoxin in biliary and pancreatic duct cannulated pigs. The study was divided in two part
Paper for the Public and Social Innovation Conference (PUBSIC), Lillehammer University College, Lillehammer, Norway, 15-17 November, 2017 Theme 7B: managing and evaluating sustainable innovation In search of a model for sustainable innovation in welfare services Katja Lindqvist & Ulrika WestrupDepartment of Service Management and Service Studies, Lund University, Swedenkatja.lindqvist@ism.lu.s
Endosomal escape and subsequent cytosolic delivery of small interfering RNA (siRNA) therapeutics is believed to be highly inefficient. Since it has not been possible to quantify cytosolic amounts of delivered siRNA at therapeutic doses, determining delivery bottlenecks and total efficiency has been difficult. Here, we present a confocal microscopy-based method to quantify cytosolic delivery of flu
A trend, which can be noted in the field of cash handling, is the increase of ATMs that are able to recirculate banknotes. Cash recycling means that notes deposited by one customer are then available for withdrawal by another from the same machine. Cash recycling has both economic advantages and reduces environment impact, as transport to machines for filling and emptying them can be decreased. Wh
Continuous dopaminergic stimulation (CDS) has become one of the main concepts in present Parkinson's disease (PD) research. This is based on the assumption that CDS, or rather near CDS, is the normal striatal setting in a healthy individual. In PD, the degeneration of dopaminergic neurons leads to a reduced capacity to buffer dopamine, which could increase the vulnerability to a pulsatile administ
There has been a strong quest for mapping and assessing ecosystem services (ES) to support governance. Yet, the institutional landscape that governs ES provision across multiple contexts has received less attention. We fill this research gap by developing and operationalising a framework for the analysis of policy documents that address European forest ES provision. By coding and analysing referen
Background: Evidence-based guidelines are needed for effective delivery of home oxygen therapy to appropriate patients with chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). Methods: The multidisciplinary panel created six research questions using a modified Delphi approach. A systematic review of the literature was completed, and the Grading of Recommendations Asse
This paper presents a model that can calculate the uptake of CO2 in all existing concrete structures, including its uptake after service life. This is important for the calculation of the total CO2 uptake in the society and its time dependence. The model uses the well-documented cement use and knowledge of how the investments are distributed throughout the building sector to estimate the stock of
This paper proposes an alternative perspective on service quality management (SQM) based on the ecosystem of complex and dynamic service environments. First, the ways in which systems thinking and core principles of Quality Management evolved are analysed in order to understand the past, present and the future. Then, by analysing the theories, models and applications of SQM systems and business ec
This paper analyses recent experiences at the School of Social Work, Lund University, the first in Sweden to use an innovative pedagogical approach for integrating social service users with social work students in the classroom (an EU-funded project). The concept of gift exchange was used to make sense of the approach. Gift exchange is based on the norm of reciprocity and the principles of gift ec
Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h
Fluxes of methane, CH4, were measured with the eddy covariance (EC) method at a small boreal lake in Sweden. The mean CH4 flux during the growing season of 2013 was 20.1 nmol m−2 s−1 and the median flux was 16 nmol m−2 s−1 (corresponding to 1.7 mmol m−2 d−1 and 1.4 mmol m−2 d−1). Monthly mean values of CH4 flux measured with the EC method were compared with fluxes measured with floating chambers (
Ability to efficiently localize productive foraging habitat is crucial for nesting success of insectivorous birds. Some bird species can use olfaction to identify caterpillar-infested trees by detection of herbivore induced plant volatiles (HIPVs), but these cues probably need to be learned. So far, we know very little about the process of olfactory learning in birds, whether insectivorous species
