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Next generation sequencing (NGS) methods have been widely used for diagnosis. As time and cost of sequencing has reduced sharply during the last decade, genome and exome-wide sequencing have increasingly been used. The genome and exome projects produce large amounts of variation data and the clinical relevance of large proportions of them are not known. Among various types of genetic variations, t
Post-quantum cryptography for resisting possible attacks from malicious quantum adversaries has become one of the key topics in recent cryptographic research. Its ultimate goal is to search for efficient and secure primitives replacing the factoring- and discrete log-based schemes in service that will be broken in polynomial time by Shor’s algorithm. It is now an urgent task to complete this repla
Prasugrel is a third-generation thienopyridine platelet P2Y12 adenosine diphosphate (ADP) receptor antagonist administered with aspirin for the treatment of patients with acute coronary syndrome (ACS) with planned percutaneous coronary intervention. Prasugrel is administered periprocedurally at an oral loading dose of 60 mg followed by daily maintenance doses (MDs) of 10 mg for most patients and 5
Thermal comfort has direction implications for energy efficiency and sustainable development. From a global perspective, about 40% of total primary energy is used in buildings, contributing to more than 30% of CO2 emissions [1]. The fact that the common practices of clothing choices have impact on energy efficiency is ignored [2-3]. This paper analyzed and proposed clothing insulation required for
Recent advancements in almost all aspects of hemophilia treatment have vastly improved patient care and management, and new and emerging treatments hold the promise of further progress. However, there remains a scarcity of data on long-term outcomes in hemophilia, particularly among those patients with inhibitors, for whom no validated outcome assessment tools are currently available. At the 15th
Over the past three decades, a range of attempts have been made to raise the importance of science, technology and innovation on the policy agenda in Africa. This article explores four themes along which growth paths and patterns may be realized, namely regional and global integration, inclusive innovation, priorities and approaches to diversify African economies, and the role of the state. The ou
The automatic detection and classification of stance (e.g., certainty or agreement) in text data using natural language processing and machine learning methods create an opportunity to gain insight into the speakers' attitudes towards their own and other people's utterances. However, identifying stance in text presents many challenges related to training data collection and classifier training. In
This paper reviews biokinetic data for ionic indium, and proposes a biokinetic model for systemic indium in adult humans. The development of parameter values focuses on human data and indium in the form of ionic indium(III), as indium chloride and indium arsenide. The model presented for systemic indium is defined by five different pools: plasma, bone marrow, liver, kidneys and other soft tissues.
OBJECTIVE: To investigate the relationship of hospital admissions due to unexplained syncope and orthostatic hypotension (OH) with subsequent cardiovascular events and mortality.METHODS: We analysed a population-based prospective cohort of 30 528 middle-aged individuals (age 58±8 years; males, 40%). Adjusted Cox regression models were applied to assess the impact of unexplained syncope/OH hospital
OBJECTIVE - Ketosis-prone diabetes (KPD) is an emerging, heterogeneous syndrome. A sound classification scheme for KPD is essential to guide clinical practice and pathophysiologic studies. Four schemes have been used and are based on immunologic criteria, immunologic criteria and insulin requirement, BMI, and immunologic criteria and β-cell function (Aβ classification). The aim of the present stud
HIV and Mycobacterium tuberculosis (MTB) are two widespread and highly successful microbes whose synergy in pathogenesis has created a significant threat for human health globally. In acknowledgement of this fact, the European Union (EU) has funded a multinational support action, the European Network for global cooperation in the field of AIDS and TB (EUCO-Net), that brings together experts from E
It has long been known that humans use the focus of expansion (FOE) in a radial optic flow pattern to perceive their instantaneous direction of self-motion (heading). Here we report that motion-streak-like form information is also used for heading perception. We presented observers with an integrated form and motion display in which the dot pairs of a radial Glass patterns were oriented toward one
This paper proposes a simple framework to model social preferences in a way that explicitly separates economic incentives from social (context) effects and allows for uncertainty also about the latter. Moreover, it allows non-economic cost associated with the deviation from some norm to be more discriminatory than just “right” or “wrong.” We refer to existing evidence on dictator game giving to de
Sustainable business model innovation is increasingly viewed as a lever for systems change for sustainability across businesses and industries. Banks hold a unique intermediary role in sustainable development, but also have a difficult position after the 2008 financial crisis. This paper aims to explore business models for sustainability in the service industry, particularly banking. It explores t
Established approaches to data aggregation in wirelesssensor networks (WSNs) do not cover the variety of new usecases developing with the advent of the Internet of Things. In particular,the current push towards fog computing, in which control,computation, and storage are moved to nodes close to the networkedge, induces a need to collect data at multiple sinks, ratherthan the single sink typically
Non-Orthogonal Multiple Access (NOMA) is studied under statistical Channel State Information (CSI) and probabilistic constraints. Unlike the conventional power domain only NOMA, the definition of NOMA here considers both the power and the frequency domains simultaneously, where a flat power spectrum is assumed for each UE. This increases the capacity region when compared to the conventional definiti
