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Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are
Low-and-middle-income countries (LMICs) bear a high burden of intimate partner violence (IPV). However, there are no reviews assimilating the factors affecting risk of IPV in LMICs. This systematic review (2010–20) identifies risk and protective factors of IPV in LMICs. We followed the PRISMA guidelines to review 399 studies and included 32 studies. Studies were of ever-partnered women living in a
The European Union (EU) Water Framework Directive is of paramount importance for water management. According to the legal text, coordination with other directives like the Floods Directive is imperative and motivated by potential synergy effects. In this paper, the degree to which such coordination is achieved is evaluated for five Nordic and Baltic countries. The evaluation is based on legal docu
Climate change is expected to alter precipitation regimes, resulting in longer periods of drought and heavier precipitation events. Even though the direct effect of water availability on soil microbial processes is well documented, the influence of precipitation legacy on microbial resistance and resilience to drought remains unclear. Using soils from a natural mean annual precipitation (MAP) grad
In the coming renewables-based energy transition, global electricity consumption is expected to double by 2050, entailing widespread end-use electrification, with significant impacts on energy efficiency. We develop a long-run, worldwide societal exergy analysis focused on electricity. Our 1900–2017 electricity world database contains the energy carriers used in electricity production, final end-u
Climate change is expected to alter the frequency and intensity of soil drying-rewetting (D/RW) and freezing-thawing (F/TW) events, with consequences for the activities of microorganisms. Although both D/RW and F/TW events cause respiration pulses from soil to the atmosphere, it remains unknown whether the underlying microbial control is similar. Recent work has revealed that soil microbial respon
Depressive and anxiety disorders are leading causes of disability globally. Therapist-guided, Internet-delivered cognitive behaviour therapy (ICBT) is an established treatment for depression and anxiety, but a considerable proportion of treated patients do not achieve sufficient improvement. Predicting symptom changes based solely on clinical variables is challenging, and genetic data could offer
Purpose: Abdominal wall complications can be reduced by adhering to guidelines for midline laparotomy closure. However, implementation of guidelines can be challenging. To address this issue, a laparotomy closure device for swift and standardized abdominal closure was developed. The study evaluated the quality of the suture, safety, and speed of the device in a clinical setting. Methods: A prospec
För att främja ett aktivt och hälsosamt åldrande (AHA) är det avgörande att förstå hur olika generationer använder digitala teknologier, då dessa verktyg blir en alltmer integrerad del av vardagen. Detta avhandlingsprojekt undersökte teknikanvändning bland kvinnor och män i tre åldersgrupper som representerar olika generationer (30–39, 50–59 och 70–79 år), med fokus på attityder, användningsmönsteTo promote active and healthy ageing (AHA), it is essential to understand how different generations engage with digital technologies, as these tools are becoming increasingly integral to everyday life. This thesis project explored technology adoption among men and women from three age groups representing different generations (30–39, 50–59 and 70–79 years), focusing on attitudes, usage patterns, a
The metalorganic chemical vapor deposition (MOCVD) dynamics of beta-gallium oxide (β-Ga2O3) growth using trimethylgallium (TMGa) and oxygen as precursors were investigated through both theoretical thermodynamic analysis and experimental validation in a horizontal low-pressure hot-wall reactor. Thermodynamic analysis revealed that high-purity β-Ga2O3 can be grown through the complete combustion of
Gamified virtual reality (VR) environments are increasingly used to enhance engagement and learning, yet most designs still adopt a one-size-fits-all approach that overlooks motivational diversity. The HEXAD framework, which classifies users into six player types, provides a promising lens for addressing this gap, but its predictive validity in immersive VR remains contested. This study investigat
Temperature impacts on microbiological processes are crucial for soil biogeochemistry and ecosystem functioning, yet existing models either fail to capture microbial temperature dependences across the full biokinetic range or risk overparameterization. Here we present the “Dual-Kinetics Ratkowsky” model (Ratkowsky DK), which simultaneously describes temperature dependences of microbial growth and
This study explores a novel approach to utilizing waste biomass for syngas production, with the potential for carbon sequestration. An integrated biomass conversion process combining pyrolysis, CO2 reforming, and MILD combustion is proposed. In the proposed system, the bio-oil obtained from pyrolysis can be used in a reforming step, converting it into syngas with a suitable H2/CO ratio for chemica
Adaptive reuse, the conversion of buildings for new functions, is gaining prominence for its cost-saving and environmental benefits. However, prior research primarily focuses on preserving the building envelope, often overlooking building services such as ventilation, which affect occupant well-being, costs, and environmental performance. This study explores a novel adaptive reuse approach by reus
Climate neutrality of cities has emerged as a critical goal for sustainable urban development. This is typified by the mission in the European Union (EU) to achieve 100 climate neutral and smart cities by 2030. The idea of carbon or climate neutrality holds diverse interpretations. This paper investigates the dominant socio-technical imaginary for urban climate neutrality within the context of the
