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Persistent increase of Nogo-A-positive cells and dynamic reduction in oligodendroglia lineage cells in white matter regions following experimental and clinical traumatic brain injury

White matter (WM) disruption and atrophy is a consequence of traumatic brain injury (TBI) and contributes to persisting cognitive impairment. An increased expression of the myelin-associated axonal outgrowth inhibitor Nogo-A and oligodendrocyte pathology might be negatively associated with postinjury WM changes. Here, we analyzed brain tissue from severe TBI patients, obtained by surgical decompre

Var sitter kompetensen? En studie om villkor för lärande i arbetet

Projektarbete har blivit en vanlig arbetsform i organisationer. Alfa Laval är ett företag som utnyttjar projektarbete för att utveckla verksamheten. Projekten leder dock inte alltid till de resultat som förväntas. För att analysera denna diskrepans vill jag lyfta fram projektledarnas uppfattning om sin arbetssituation. Studiens syfte är att belysa och analysera villkor för projektledarnas kompeten

Looparna som en väg mot utveckling : en empirisk studie av organisationens kompetensutvecklingsstrategier

Bakgrund: Kunskapsintensivt arbete utgör en allt större del av näringslivet idag. Morgondagens vinnare blir de företag med den mest kompetenta personalen. Organisationen som ligger till grund för detta arbete står inför en omfattande förändring som en del av organisationens strategi för att uppnå en långsiktig konkurrenskraft. För att möjliggöra detta krävs en kompetensutvecklingsstrategi som även

Transcriptional Responses as Biomarkers of General Toxicity : A Systematic Review and Meta-Analysis on Metal-Exposed Bivalves

Through a systematic review and a series of meta-analyses, we evaluated the general responsiveness of putative transcriptional biomarkers of general toxicity and chemical stress. We targeted metal exposures performed on bivalves under controlled laboratory conditions, and selected six transcripts associated with general toxicity for evaluation: catalase (cat), glutathione-S-transferase (gst), heat

From Subsistence to Commercial Producers : Processes of State-led Agrarian Change, Land Tenure Dynamics and Social Differentiation among Smallholders in Ghana.

Agricultural commercialization is concerned with improving market-oriented production in expectation of maximizing profit. While previous state policies in Ghana favoured commercialization by medium and large scale cultivators, there exists a new national commitment dubbed the Planting for Food and Jobs Policy that seeks to leverage on the cumulative productive potential of small farmers for susta

EEG monitoring after cardiac arrest

Hypoxic–ischaemic brain injury (HIBI) is the main causeof death and disability in patients who are comatose afterreturn of spontaneous circulation (ROSC) from cardiacarrest [1]. Te electroencephalogram (EEG) is a usefultool to assess the severity of HIBI and provide prognostic information. In addition, EEG can be used to diagnoseepileptiform activity in patients with suspected seizuresand monitor

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To investigate the consumption of alcohol among emergency room patients, we included 395 patients above 18 years old entering the emergency room during a period of ten days. The patients completed a questionnaire about alcohol consumption, smoking habits and medication. In our investigation 56% of the men and 25% of the women had a daily consumption above the limits recommended by the Ministry of

Large Eddy Simulation and Experimental Analysis of Combustion Dynamics in a Gas Turbine Burner

Large eddy simulations (LES) and experiments (planar laser-induced fluorescence of the hydroxyl radical (OH-PLIF) and pressure transducer) have been carried out on a gas turbine burner fitted to an atmospheric combustion rig. This burner, from the Siemens SGT-800 gas turbine, is a low NOx, partially premixed burner, where preheat air temperature, flame temperature, and pressure drop across the bur

γ-aminobutyric acid and taurine release in the striatum of the rat during hypoglycemic coma, studied by microdialysis

Extracellular levels of striatal γ-aminobutyric acid (GABA) and taurine were monitored during insulin-induced hypoglycemia using microdialysis. At the onset of isoelectricity in the electroencephalogram (EEG), a transient 5-fold increase in the levels of GABA occurred. Taurine levels increased 5 min following the onset of isoelectricity and continued to increase during the entire isoelectric perio

Improvement in indices of cellular protection after psychological treatment for social anxiety disorder

Telomere attrition is a hallmark of cellular aging and shorter telomeres have been reported in mood and anxiety disorders. Telomere shortening is counteracted by the enzyme telomerase and cellular protection is also provided by the antioxidant enzyme glutathione peroxidase (GPx). Here, telomerase, GPx, and telomeres were investigated in 46 social anxiety disorder (SAD) patients in a within-subject

Svenska rådet för HLR ska öka överlevnaden vid hjärtstopp

It is estimated that about 30 000 people a year are successfully resuscitated after having suffered an out-of-hospital cardiac arrest in Europe. The number of patients that are successfully resuscitated after an in-hospital cardiac arrest is not known, but it can be assumed that this figure is even higher than that after an out-of-hospital cardiac arrest. The aim of the Swedish Resuscitation Counc

Enzymatic peptide synthesis in organic media : a comparative study of water-miscible and water-immiscible solvent systems

Peptide synthesis was carried out in a variety of organic solvents with low contents of water. The enzyme was deposited on the support material, celite, from an aqueous buffer solution. After evaporation of the water the biocatalyst was suspended in the reaction mixtures. The chymotrypsin-catalyzed reaction between Z-Phe-OMe and Leu-NH2 was used as a model reaction. Under the conditions used ([Z-P

1H NMR diffusometry study of water in casein dispersions and gels

The self-diffusion coefficients of water in casein solutions and gels were measured using a pulsed-gradient spin-echo nuclear magnetic resonance technique (PGSE NMR). The dependence of the self-diffusion coefficient of water on the concentration and structure-of casein is reported. The results were analyzed using a cell model. It was found that the water self-diffusion coefficient is insensitive t