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BACKGROUND Men and women with type 1 long QT syndrome (LQT1) exhibit time-dependent differences in the risk for cardiac events. OBJECTIVE We hypothesized that sex-specific risk for LQT1 is related to the location and function of the disease-causing mutation in the KCNQ1 gene. METHODS The risk for life-threatening cardiac events (comprising aborted cardiac arrest [ACA] or sudden cardiac death [SCD]
Purpose: The purpose of this study was to investigate, using simulations, a method for improved contrast agent (CA) quantification in DCE-MRI. Methods: We developed a maximum likelihood estimator that combines the phase signal in the DCE-MRI image series with an additional CA estimate, e.g. the estimate obtained from magnitude data. A number of simulations were performed to investigate the ability
This study investigated how visitors and staff in community-based activity centers in Sweden perceived the psychosocial atmosphere and whether this could be explained by the centers' orientation (work-oriented versus meeting place-oriented centers). Eighty-eight visitors and 37 staff members at three work-oriented and three meeting place-oriented centers participated. The Community-oriented Progra
Sample treatment is an essential element when using real-time PCR for quantification of pathogens directly on food samples. This study comparatively evaluated three different principles of sample treatment, i.e. immunomagnetic separation based on phage-derived cell wall binding molecules, matrix solubilization and flotation, in order to establish their suitability for quantifying low numbers of St
Non-diabetic children with multiple islet autoantibodies were recruited to a secondary prevention trial. The objective was to determine the predictive value of baseline (1) HbA1c and metabolic variables derived from intravenous (IvGTT) and oral glucose tolerance tests (OGTT), (2) insulin resistance and (3) number, type and levels of islet autoantibodies, for progression to type 1 diabetes.
surgery (i.e. resection or liver transplantation), but only 10-20% of patients are candidates for this. In other patients, a variety of palliative treatments can be given, such as chemoembolization, radiofrequency ablation or recentlyPrimary liver cancers (i.e. hepatocellular carcinoma or cholangiocarcinoma) are worldwide some of the most frequent cancers, with rapidly fatal liver failure in a lar
The influence of chronological ageing on the components of the cardiovascular system is of fundamental importance for understanding how hemodynamics change and the cardiovascular risk increases with age, the most important risk marker. An increase in peripheral vascular resistance associated with increased stiffness of central elastic arteries represents hallmarks of this ageing effect on the vasc
In the field of renewable energy, self-provided research in developing countries is barely present, but most welcomed. The creation of know-how and self-development of technologies should reduce the dependence on industrialized countries for both materials and knowledge. This work presents technological and social issues related to the construction of a low budget solar laboratory in Mozambique. T
Objective: To determine the association between radiographic osteoarthritis (OA) and pre-operative function in patients undergoing primary knee replacement. Methods: Single centre study examining pre-operative outcomes in a consecutive series of 525 patients who underwent primary knee replacement for OA between January 2006 and December 2007. Pre-operative data included: demographics, American Soc
The purpose of this study is to present a new and improved method for translating the electrocardiographic changes of acute myocardial ischemia into a display which reflects the location and extent of the ischemic area and the associated culprit coronary artery. This method could be automated to present a graphic image of the ischemic area in a manner understandable by all levels of caregivers; fr
Data on the potential effect of obesity and diabetes mellitus on survival after liver resection due to colorectal cancer (CRC) metastases are very limited.
Mixtures of two cationic proteins were used to prepare protein-DNA gel particles, employing associative phase separation and interfacial diffusion (Moran et al., 2009a). By mixing the two proteins, we have obtained particles that displayed higher loading efficiency and loading capacity values than those obtained in single-protein systems. However, nothing is known about the adverse effects on haem
Polymeric anion-exchange membranes (AEMs) are critical components for alkaline membrane fuel cells (AMFCs) which offer several attractive advantages including the use of platinum-free catalysts and a wide choice of fuel. The development of AMFCs and other electrochemical energy systems is currently severely limited by the lack of AEMs with sufficient alkaline stability. Still, significant advances
The uptake of nutrients from deep soil layers has been shown to be important for the long-term nutrient sustainability of forest soils. When modelling nutrient uptake in forest ecosystems, the nutrient uptake capacity of trees is usually defined by the root distribution. However, this leads to the assumption that roots at different soil depths have the same capacity to take up nutrients. To invest
Popular Abstract in Swedish Sedimentära bergarter såsom t.ex. sandstenar och lerskiffrar, bildas genom att lösa sediment (t.ex. sand och lera) ”bakas” hårda när de sjunker ned i jordskorpan. Anledningen till att många lagerföljder rör sig nedåt i jordskorpan beror till viss del på de ovanliggande sedimentens tyngd, men är i huvudsak ett resultat av de platt-tektoniska rörelser som hela tiden påverPost-depositional thermal conditions have been investigated throughout the Phanerozoic sedimentary succession in Skåne. Clay mineralogy and illite crystallinity have been the main tools for the Lower Palaeozoic strata. Within the Mesozoic sequence thermal influence was examined using RockEval pyrolysis and vitrinite reflectance analysis. Clay mineralogy of the Lower Palaeozoic shales and mudstone
Respiratory tract deposition data of ultrafine aerosol particles, hygroscopic particles and ambient particles in general are scarce. Measurements are associated with several difficulties. The objective of this work was to design a method for fast determination of highly size-resolved fine and ultrafine particle deposition, to be used on larger groups of human subjects in exposure studies and in ty
The overall aim of this thesis was to describe changes in the prevalence and severity of periodontal diseases and to identify risk factors for severe periodontal disease in adults living in Jönköping County, Sweden, by analysing the cross-sectional, epidemiological studies that had been carried out in the city of Jönköping in 1973, 1983, and 1993. Individuals were randomly selected from the follow
Background and Objectives. Although anagrelide is widely used in the treatment of throm-bocythemia in myeloproliferative diseases, there is currently limited information on the efficacy and toxicity of its long-term use. This prospective study investigated clinical toxicity and efficacy of anagrelide during two years of treatment. Design and Methods. A multicenter, open, phase II study of anagreli
