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Cell entry of Simian Virus 40 (SV40) involves caveolar/lipid raft-mediated endocytosis, vesicular transport to the endoplasmic reticulum (ER), translocation into the cytosol, and import into the nucleus. We analyzed the effects of ER-associated processes and factors on infection and on isolated viruses and found that SV40 makes use of the thiol-disulfide oxidoreductases, ERp57 and PDI, as well as
Att ersätta ändliga resurser med förnybara alternativ är en av mänsklighetens största utmaningar i modern tid. Utsläpp av växthusgaser orsakade av mänsklig civilisation behöver minska, och nya forskningsbaserade lösningar är nödvändiga för att åstadkomma långsiktigt hållbar tillväxt. I denna omställning kan biomassa från växter spela en viktig roll. Växtbiomassa består mestadels av socker som sittβ-Mannanases are a major type of enzyme involved in the hydrolysis and modification of β-mannans, a hemicellulose present in high amounts in e.g. softwoods such as spruce. The β-mannanases studied in this thesis belong to glycoside hydrolase (GH) families GH5 and GH26. In addition to hydrolysis, some β-mannanases can also catalyze transglycosylation whereby another molecule (acceptor) is transferr
Cellobiose dehydrogenase (CDH) is a versatile bioelectrocatalyst lately at focus due to its sugar oxidising properties in combination with its inherent ability for direct electron transfer communication with electrodes making it possible to be used in bioanodes in the enzymatic fuel cells (EFCs), self-powered biosensors, and biosupercapacitors. During the last 20 years, many new nanomaterials and
Empirical software engineering research aims to generate prescriptive knowledge that can help software engineers improve their work and overcome their challenges, but deriving these insights from real-world problems can be challenging. In this paper, we promote design science as an effective way to produce and communicate prescriptive knowledge. We propose using a visual abstract template to commu
The financial position of the medical insurance system of Japanese government has been worsened recently, and thus the Ministry of Health, Labor and Welfare has prompted the medical reforms to reconstruct the financial balance of the medical insurance system. As one of these efforts, a fixed payment system for medical services based on “DPC” (Diagnosis Procedure Combination) was introduced to a nu
An iterative receiver for Multiple-Input Multiple-Output (MIMO) Orthogonal Frequency Division Multiplexing (OFDM) wireless systems is presented and tested on channel measurements from a real indoor scenario. The receiver jointly performs channel estimation and multiuser detection, with soft information iteratively provided by the singleuser decoders. Results for the performance are presented in te
The extreme soil conditions in metalliferous mine soils have a negative influence on soil biological activity. Therefore, amendments are often used to improve soil quality and activate microbial communities. In order to elucidate some of the factors controlling microbial growth and community structure after application of amendments in acid mine soils, we performed an incubation experiment with fo
This paper addresses the challenge of how to understand and handle divergent views on the need for leadership interventions between managers and subordinates. Recent popular discourses of leadership, such as the authentic leadership perspective, privileges the potential leader himself or herself as the origin of leadership. This perspective thereby neglects the view of the followers and the essent
Summary The egress strategy in high-rise buildings has traditionally been based on the sole use of stairs for evacuation. However, it is becoming more common to include evacuation elevators in the egress strategy in high-rise buildings. Traditionally, evacuation elevators have not been allowed as an evacuation route, and people have been instructed to not use elevators in case of fire. This means
Objective: contribute to the existing body of knowledge about the specific needs of first-time parents specifically for early parenthood. Method: the databases PubMed, MEDLINE, PSYCINFO, CINAHL, EMBASE, Family Studies Abstracts, and Web of Science, were searched using search terms: prenatal, antenatal, preparation, education, parents, parenthood. The meta-synthesis included 12 articles representin
This article quantifies the energy saving potential and robustness of nine energy retrofitting measures, as well as four combinations of these, for residential building stocks of three major cities in Sweden and for five scenarios of future climatic conditions, downscaled by a regional climate model (RCM). The retrofitting measures are evaluated for five temporal resolutions of hourly, daily, mont
Introduction: Persistent hypertension is a key risk factor for coronary heart disease, stroke and other cardiovascular diseases, such as heart failure. For primary care physicians, hypertension is the number one diagnosis for office visits and for our communities, the treatment of high blood pressure (BP) and its consequences constitutes a substantial economic burden. Aim: To evaluate yoga as a tr
Increasing trends of natural organic matter (NOM) in surface water in Nordic countries may cause future problems for drinking water producers. Emerging membrane technology, such as ultrafiltration (UF) and nanofiltration (NF), has the potential to produce safe drinking water of good quality from sources with high organic concentrations. In the present pilot study, surface water from three sources
The identification and validation of biomarkers for clinical applications remains an important issue for improving diagnostics and therapy in many diseases, including prostate cancer. Gene expression profiles are routinely applied to identify diagnostic and predictive biomarkers or novel targets for cancer. However, only few predictive markers identified in silico have also been validated for clin
Despite increasing access to antiretroviral treatment (ART) in low-income countries, HIV-related mortality is high, especially in the first months following ART initiation. We aimed to evaluate the impact of TB coinfection on early mortality and to assess gender-specific predictors of mortality in a cohort of Ethiopian adults subjected to intensified casefinding for active TB before starting ART.
In this study, a rapid and sensitive ultra-high performance supercritical fluid chromatography-mass spectrometry (UHPSFC-MS) method has been developed and partially validated for the separation of carotenoids within less than 6 min. Six columns of orthogonal selectivity were examined, and the best separation was obtained by using a 1-aminoanthracene (1-AA) column. The length of polyene chain as we
OBJECTIVE:: To evaluate auditory and vestibular function after presurgical treatment with gentamicin in schwannoma patients. BACKGROUND:: The vestibular PREHAB protocol aims at diminishing the remaining vestibular function before vestibular schwannoma surgery, to ensure less acute symptoms from surgery, and initiate a more efficient vestibular rehabilitation already before surgery. However, the po
